Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Expression of Bcl-2 in the epithelial lining and clinical findings of keratocystic odotogenic tumor

각화낭치성종양의 이장상피에서 Bcl-2 발현양상과 임상지표

  • Lee, In-Hyuk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Choi, So-Young (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Park, Ji-Hoon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Kim, Chin-Soo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University)
  • 이인혁 (경북대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 최소영 (경북대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 박지훈 (경북대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김진수 (경북대학교 치의학전문대학원 구강악안면외과학교실)
  • Received : 2011.03.02
  • Accepted : 2011.06.01
  • Published : 2011.06.30
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Abstract

Purpose: The odontogenic keratocysts demonstrated a high recurrence rate and a biologically aggressive nature. This might be due to unknown factors inherent in the epithelium or enzymatic activity in the fibrous wall. Bcl-2 protein is characterized by its ability to inhibit apoptosis. The aim of this study was to evaluate the expression and distribution of bcl-2 in the OKCs, its possible relationship with the tumorous characteristics, such as the aggressive nature and high recurrence rate, and its usefulness to differentiate OKCs from dentigerous cysts. Materials and Methods: Formalin fixed paraffin-embedded tissue sections of 53 OKCs, and 44 dentigerous cyst were immunohistochemically analyzed quantitatively for the immunoreactivity of the bcl-2 protein with i-solution. Results: More Bcl-2 expression was observed in the OKCs (mean34.387%) than dentigerous cyst (mean11.144%) with statistical significance (P<0.001). Seventeen and 15 of the 32 OKCs in this study showed positivity in the basal layer and basal/suprabasal layers, respectively. In dentigerous cyst, 2 of 3 showed positivity in the basal cell layer. Conclusion: Considering that bcl-2 over expression may lead to the increased survival of epithelial cells, this study demonstrated a possible relationship between the aggressive nature of OKC and the intrinsic growth potential of its lining epithelium. Furthermore, the basal/suprabasal distribution of bcl-2 positive cells was observed in some OKCs, which might have a significant impact on the behavior of cysts. The bcl-2 expression of OKCs can be useful for differentiating OKCs from dentigerous cysts.

Keywords

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