대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

Lipid-lowering and Antioxidant Effects of Curcuma Radix in Poloxamer 407-induced Hyperlipidemia Model Rat Models

  • Park, So-Ae (Division of Circulatory System, Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University) ;
  • Jo, Hyun-Kyung (Division of Circulatory System, Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University) ;
  • Yoo, Ho-Ryong (Division of Circulatory System, Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University) ;
  • Kim, Yoon-Sik (Division of Circulatory System, Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University) ;
  • Seol, In-Chon (Division of Circulatory System, Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University) ;
  • An, Joung-Jo (Division of Circulatory System, Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University)
  • 발행 : 2011.06.30
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초록

Objectives : This study investigated the hypolipidemic and antioxidant effects of Curcuma radix using a rat model induced by poloxamer 407 injection. Methods : Serum lipid parameters and oxidative stress-associated biomarkers were determined. Additionally, hepatic cholesterol and triglyceride as well as lipid metabolism-associated gene expressions were observed in hepatic tissue. Results : 1. Curcuma radix ameliorated elevation of serum cholesterol, triglyceride, LDL-cholesterol, MDA, hepatic cholesterol level, and reduction of serum TAC, SOD, GSH, GSH-reductase level. 2. Curcuma radix augmented up-regulated ACAT gene expression. 3. Curcuma radix almost completely ameliorated down-regulated CYP-7A1 but up-regulated HMG-CoA gene expression. Conclusions : The hypolipidemic and antioxidant properties of Curcuma radix were evidenced. This study provides a scientific basis for the clinical application of Curcuma radix and development of hypolipidemics using this herb in the future.

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