개의 에스트로겐과 프로케스테론 수용체 발현이 되지 않은 자궁 선암종 증례

A Case of Canine Uterine Adenocarcinoma with Negative Estrogen and Progesterone Receptor Expression

  • 조향미 (전북대학교 수의과대학 수의임상병리학과) ;
  • 김현욱 (해마루 동물병원) ;
  • 김혜진 (해마루 동물병원) ;
  • 최지혜 (해마루 동물병원) ;
  • 장재영 (해마루 동물병원) ;
  • 최을수 (전북대학교 수의과대학 수의임상병리학과)
  • Cho, Hyang-Mi (Departments of Veterinary Clinical Pathology, College of Veterinary Medicine, Bio-Safety Research Institute, Chonbuk National University) ;
  • Kim, Hyun-Wook (Haemaru Referral Animal Hospital) ;
  • Kim, Hye-Jin (Haemaru Referral Animal Hospital) ;
  • Choi, Ji-Hye (Haemaru Referral Animal Hospital) ;
  • Jang, Jae-Young (Haemaru Referral Animal Hospital) ;
  • Choi, Ul-Soo (Departments of Veterinary Clinical Pathology, College of Veterinary Medicine, Bio-Safety Research Institute, Chonbuk National University)
  • 심사 : 2011.05.30
  • 발행 : 2011.06.30

초록

프로게스테론 제제를 복용해 오던 12세령의 암컷 잡종 견이 복부 종괴의 평가를 위해 내원하였다. 복부 초음파 검사와 방사선 검사를 통해 확장된 자궁과 관련된 종괴를 확인하였다. 혈청 화학 검사에서는 고글로불린혈증이 나타났으며, 전기영동 검사상 급성 염증 패턴으로 판단되었다. 초음파 유도하에 종괴의 세침흡인을 실시하였으며 세포학검사를 통해 선암종이 진단되었다. 탐색적 개복을 실시하였으며 장구체의 종괴를 발견하여 자궁과 함께 종괴를 제거하는 수술을 실시하였다. 조직병리 검사결과 자궁 선암종이 진단되었으며 종양세포의 에스트로겐 수용체와 프로게스테론 수용체 발현 여부 평가를 위해 면역 염색을 실시하였다. 면역염색결과 종양세포는 두 항체에 대해 음성 결과를 보였으며, 정상 간엽세포에서만 양성 결과가 나타났다. 수술 후 1주일에 재검을 위해 내원하였는데 컴퓨터 단층촬영 검사결과 폐 전이가 확인되었다. 환자는 수술 후 40일경에 폐사하였다.

A 12-year-old female mixed breed dog receiving a progesterone drug was referred for evaluation of an abdominal mass. Abdominal radiography and ultrasonography revealed a swollen uterus and an associated mass. Serum chemistry revealed hyperglobulinemia consistent with acute inflammation based on the results of serum protein electrophoresis. Fine needle aspiration of the mass guided by ultrasonography was performed for cytological evaluation. The cytological impression was consistent with adenocarcinoma. Exploratory laparotomy identified a uterine body mass, which was surgically removed for histopathology. Histology of the mass identified a uterine adenocarcinoma. Immunochemistry using anti-estrogen and progesterone receptor antibodies was performed and neoplastic cells were negative to both antibodies while some normal elements were reactive to both of them. Computer tomography demonstrated evidence of metastatic disease in the lung one week after the surgery and the dog died about 40 days after surgery.

키워드

참고문헌

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