한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제28권3호
  • /
  • Pages.291-296
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  • 2011
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

돼지에서 Medetomidine-ketamine 마취에 대한 Atipamezole과 Yohimbine의 길항효과

Antagonistic Effects of Atipamezole and Yohimbine against Anesthesia with Medetomidine and Ketamine Combination in Pigs

  • 이재연 (충남대학교 수의과대학) ;
  • 김명철 (충남대학교 수의과대학)
  • Lee, Jae-Yeon (College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Kim, Myung-Cheol (College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University)
  • 심사 : 2011.06.13
  • 발행 : 2011.06.30
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초록

돼지에서 medetomidine-ketamine (MK) 합제에 대한 마취효과와 이 합제에 대한 atipamezole (MKA) 과 yohimbine (MKY)의 길항효과를 비교하였다. 24 마리 Landrace - Yorkshire 혼혈 종 돼지를 사용하였다. Medetomidineketamine 는 한 주사기로 근육주사 하였고 atipamezole 과 yohimbine 은 마취 후 20 분에 정맥 주사 하였다. 평균마취시간, 평균흉와시간, 평균기립시간 및 평균보행시간은 MKA와 MKY군에서 MK군보다 유의적으로 짧았다. 그러나 MKA군과 MKY군간의 유의적인 차이는 없었다. 평균혈압은 MKA와 MKY군에서 MK군보다 유의적으로 낮았다. 결론적으로 Medetomidine-ketamine 에 의한 마취 및 혈압 상승 효과는 atipamezole과 yohimbine 에 의해 안전하고 빠르게 길항되었다. 따라서 atipamezole과 yohimbine은 돼지에서 Medetomidine-ketamine 마취를 길항하는 데 안전하고 효과적으로 사용될 수 있다.

The aims of the present study were to investigate the anesthetic and hemodynamic effects of medetomidine-ketamine combination and to compare antagonistic effects of atipamezole and yohimbine on the recovery of pig from anesthesia induced by medetomidine-ketamine combination. Landrace and Yorkshire cross-bred pigs were evaluated in the present study. Pigs (n = 8) received three different treatments (one treatment per 14 days in a random order). All pigs were injected intramuscularly with medetomidine, and ketamine in a single syringe. Intravenous injections of atipamezole (MKA), yohimbine (MKY), or a control saline solution (MK) were administered 20 minutes after the medetomidine-ketamine combination injection. The intravenous antagonist injections quickly reversed the medetomidine-ketamine induced sedation in the pigs, resulting in a significantly shorter duration of anesthesia in the MKA and MKY groups compared to the MK group. Mean arterial pressure (MAP) levels were significantly lower in the MKA and MKY groups compared to the MK group. Scores for posture and responses to noxious stimuli after atipamezole and yohimbine administration were significantly lower in the MKA and MKY groups than in the MK. In conclusion, the sedative effects and increases in blood pressure induced by a medetomidine-ketamine combination were quickly and smoothly reversed by atipamezole or yohimbine.

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참고문헌

  1. Henke J, Astner S, Brill T, Eissner B, Busch R, Erhardt W. Comparative study of three intramuscular anaesthetic combinations medetomidine/ketamine, medetomidine/fentanyl/midazolam and xylazine/ketamine) in rabbits. Vet Anaesth Analg 2005; 32: 261-270. https://doi.org/10.1111/j.1467-2995.2005.00242.x
  2. Henrikson H, Jensen-Waern M, Nyman G. Anesthetics for general anesthesia in growing pigs. Acta Vet Scand 1995; 36: 401-411.
  3. Henke J, Roberts U, Otto K, Lendl C, Matis U, Brill T, Erhardt W. Clinical investigations of an i.m. combination anesthesia with fentanyl/climazolam/xylazine and postoperative i.v. antagonism with naloxone/sarmazenil/yohimbine in guinea pigs. Tierarztl Prax 1996; 24: 85-87.
  4. Hsu WH. Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents. J Pharmacol and Exp Ther 1981; 218: 188-192.
  5. Kreeger TJ, Seal US, Faggella AM. Xylazine hydrochloride-ketamine hydrochloride immobilization of wolves and its antagonism by tolazoline hydrochloride. J Wildl Dis 1986; 22: 397-402. https://doi.org/10.7589/0090-3558-22.3.397
  6. Ko JC, McGrath CJ. Effects of atipamezole and yohimbine on medetomidine-induced central nervous system depression and cardiorespiratory changes in lambs. Am J Vet Res 1995; 56: 629-632.
  7. Kollias-Baker CA, Court MH, Williams LL. Influence of yohimbine and tolazoline on the cardiovascular, respiratory, and sedative effects of xylazine in the horse. J Vet Pharmacol Ther 1993; 16: 350-358. https://doi.org/10.1111/j.1365-2885.1993.tb00182.x
  8. Maze M, Tranquilli W. Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 1991; 74: 581-605. https://doi.org/10.1097/00000542-199103000-00029
  9. Nishimura R, Kim H, Matsunaga S, Sakaguchi M, Sasaki N, Tamura H, Takeuchi A. Antagonism of medetomidine sedation by atipamezole in pigs. J Vet Med Sci 1992; 54: 1237-1240. https://doi.org/10.1292/jvms.54.1237
  10. Nishimura R, Kim HY, Matsunaga S, Hayashi K, Tamura H, Sasaki N, Takeuchi A. Cardiopulmonary effects of medetomidine-midazolam and medetomidine-midazolam- atipamezole in laboratory pigs. J Vet Med Sci 1994; 56: 359-363. https://doi.org/10.1292/jvms.56.359
  11. Sakaguchi M, Nishimura R, Sasaki N, Ishiguro T, Tamura H, Takeuchi A. Sedative effects of medetomidine in pigs. J Vet Med Sci 1992; 54: 643-647. https://doi.org/10.1292/jvms.54.643
  12. Sakaguchi M, Nishimura R, Sasaki N, Ishiguro T, Tamura H, Takeuchi A. Chemical restraint by medetomidine-ketamine and its cardiopulmonary effects in pigs. Zentralbl Veterinarmed A 1995; 42: 293-299 https://doi.org/10.1111/j.1439-0442.1995.tb00380.x
  13. Sakaguchi M, Nishimura R, Sasaki N, Ishiguro T, Tamura H, Takeuchi A. Anesthesia induced in pigs by use of a combination of medetomidine, butorphanol, and ketamine and its reversal by administration of atipamezole. Am J Vet Res 1996; 57: 529-534.
  14. Savola JM, Ruskoaho H, Puurunen J, Salonen JS, Karki NT. Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoreceptors J Auton Pharmacol 1986; 6: 275-284. https://doi.org/10.1111/j.1474-8673.1986.tb00654.x
  15. Sontakke SD, Umapathy G, Shivaji S. Yohimbine antagonizes the anaesthetic effects of ketamine-xylazine in captive Indian wild felids. Vet Anaesth Analg 2009; 36: 34-41. https://doi.org/10.1111/j.1467-2995.2008.00427.x
  16. Vainio OM, Bloor BC, Kim C. Cardiovascular effects of a ketamine-medetomidine combination that produces deep sedation in Yucatan mini swine. Lab Anim Sci 1992; 42: 582-588.
  17. Verstegen J, Fargetton X, Zanker S, Donnay I, Ectors F. Antagonistic activities of atipamezole, 4-aminopyridine and yohimbine against medetomidine/ketamine-induced anesthesia in cats. Vet Rec 1991; 128: 57-60. https://doi.org/10.1136/vr.128.3.57