Natural Product Sciences

  • 제17권2호
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  • Pages.135-141
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  • 2011
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Anti-metastatic Effects of Celastrus orbiculatus Extract in B16F10 Melanoma Cells

  • Jeon, Hoon (College of Pharmacy, Woosuk University)
  • 투고 : 2011.02.28
  • 심사 : 2011.05.28
  • 발행 : 2011.06.30
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⟨ 이전 논문 다음 논문 ⟩

초록

Celastrus orbiculatus has been widely used as a traditional medicine for the treatment of many diseases including rheumatoid arthritis and odontalgia. In the present study, anti-metastatic activity of a methanolic extract from C. orbiculatus (MCO) was studied. A gelatin zymographic assay revealed that MCO has potent inhibitory effects on MMP-2 and MMP-9 activities in B16F10 melanoma cells. Moreover, MCO attenuated MMP expression via down-regulation of NF-${\kappa}$B translocation to the nucleus. Melanoma cell migration and invasion were also down-regulated by MCO. In addition, MCO significantly suppressed lung metastasis in an in vivo model. These results strongly suggest that MCO may possibly be used as a valuable anti-metastatic agent for cancer treatment.

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참고문헌

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