Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-metastatic Effects of Celastrus orbiculatus Extract in B16F10 Melanoma Cells

  • Jeon, Hoon (College of Pharmacy, Woosuk University)
  • Received : 2011.02.28
  • Accepted : 2011.05.28
  • Published : 2011.06.30
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Abstract

Celastrus orbiculatus has been widely used as a traditional medicine for the treatment of many diseases including rheumatoid arthritis and odontalgia. In the present study, anti-metastatic activity of a methanolic extract from C. orbiculatus (MCO) was studied. A gelatin zymographic assay revealed that MCO has potent inhibitory effects on MMP-2 and MMP-9 activities in B16F10 melanoma cells. Moreover, MCO attenuated MMP expression via down-regulation of NF-${\kappa}$B translocation to the nucleus. Melanoma cell migration and invasion were also down-regulated by MCO. In addition, MCO significantly suppressed lung metastasis in an in vivo model. These results strongly suggest that MCO may possibly be used as a valuable anti-metastatic agent for cancer treatment.

Keywords

References

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