YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Sedative Effects of Ethanol Extract from Cimicifugae Rhizoma

승마 에탄올 추출물의 진정 효과

  • Choi, Yun-Jung (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Yoon, Seo-Young (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Choi, Ji-Young (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Woo, Tae-Seon (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Son, Kun-Ho (Department of Food Science and Nutrition, Andong National University) ;
  • Lee, Yong-Soo (Department of Pharmacology, College of Pharmacy, Duksung Women's University) ;
  • Cheong, Jae-Hoon (Uimyung Research Institute for Neuroscience, Sahmyook University)
  • 최윤정 (삼육대학교 의명신경과학연구소) ;
  • 윤서영 (삼육대학교 의명신경과학연구소) ;
  • 최지영 (삼육대학교 의명신경과학연구소) ;
  • 우태선 (삼육대학교 의명신경과학연구소) ;
  • 손건호 (안동대학교 식품영양학과) ;
  • 이용수 (덕성여자대학교 약학대학 약학과) ;
  • 정재훈 (삼육대학교 의명신경과학연구소)
  • Received : 2011.02.28
  • Accepted : 2011.04.27
  • Published : 2011.06.30
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Abstract

The aim of this study is to evaluate the sedative effects of ethanol extract and the three major constituents of Cimicifugae Rhizoma. They decreased locomotor activity significantly, and enhanced sleeping duration induced by thiopental sodium. The ethanol extract of Cimicifugae rhizoma and 24-epi-7,8-didehydrocimigenol-3-xyloside (24-epi.) increased the $Cl^-$ influx into the intracellular area of SH-SY5Y neuroblastoma cells significantly. The present results demonstrate that the sedative effects of Cimicifugae rhizoma are mediated via the GABA-gated $Cl^-$ channel, partly by 24-epi.

Keywords

References

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