Korean Journal of Agricultural Science (농업과학연구)

Institute of Agricultural Science, CNU (충남대학교 농업과학연구소)
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Free radical scavenging activity and protective effect from cellular oxidative stress of active compound from eggplant (Solanum melongena L.)

가지(Solanum melongena L.) 활성물질의 라디칼 소거능과 산화적 스트레스에 대한 세포 보호 효과

  • Kim, Hyun-Young (Department of Food Science, Gyeongnam National University of Science and Technology) ;
  • Cho, Yun-Ju (Department of Food Science and Nutrition & Research Institute of Ecology for the Elderly, Pusan National University) ;
  • Yamabe, Noriko (Institute of Natural Medicine, University of Toyama) ;
  • Cho, Eun-Ju (Department of Food Science and Nutrition & Research Institute of Ecology for the Elderly, Pusan National University)
  • 김현영 (경남과학기술대학교 식품과학부) ;
  • 조윤주 (부산대학교 식품영양학과 및 노인생활환경연구소) ;
  • ;
  • 조은주 (부산대학교 식품영양학과 및 노인생활환경연구소)
  • Received : 2011.11.03
  • Accepted : 2011.12.18
  • Published : 2011.12.31
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Abstract

To investigate the protective effect of eggplant (Solanum melongena L.) and its active compound, delphinidin, we used in vitro and cellular system. The active fraction from eggplant, BuOH fraction, showed protective effect from hydrogen peroxide-induced oxidative stress in WI-38 fibroblast cells. It suggests that eggplant would have the protective activity from radical-induced oxidative damage and its BuOH fraction would play the crucial role with antioxidative activity. In addition, delphinidin, the active compound from eggplant, exerted the strong 1,1-diphenyl-2-picrylhydrazyl scavenging effect with $IC_{50}$ value of 6.59 ${\mu}g/mL$. Furthermore, the cellular oxidative stress was induced by 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) in LLC-$PK_1$ cells, while treatment of delphinidin atteunated AAPH-induced oxidative stress as dose-dependent manner. The present study suggests the antioxidative activity of eggplant and delphinidin against free radical-induced oxidative stress.

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References

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