Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)

Korean Society for Clinical Pharmacology and Therapeutics (대한임상약리학회)
권호 표지

Analysis of Plasma Long-Chain Fatty Acids in Hypertensive Patients

고혈압 환자에서 혈장 내 Long-Chain Fatty Acids 성분 분석

  • Kim, Jong-Sun (Department of Pharmacology, Keimyung University School of Medicine) ;
  • Kwon, Gee-Youn (Department of Pharmacology, Keimyung University School of Medicine) ;
  • Kim, Soo-Kyung (Department of Pharmacology, Keimyung University School of Medicine)
  • 김종선 (계명대학교 의과대학 약리학교실) ;
  • 권지윤 (계명대학교 의과대학 약리학교실) ;
  • 김수경 (계명대학교 의과대학 약리학교실)
  • Received : 2011.05.19
  • Accepted : 2011.09.30
  • Published : 2011.12.30
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Abstract

Background: Numerous studies have suggested that polyunsaturated fatty acids (PUFAs)-supplemented diets may decrease cardiovascular morbidity and mortality. Especially, ${\omega}$-3 PUFAs may exert beneficial effects to the treatment and prevention of dyslipidemias, arrhythmias, atherosclerosis, and hypertension. Methods: This study investigated plasma lipid profiles including total cholesterol, triglycerides (TG), LDL, HDL, and antioxidant status indicative of vitamin A, vitamin E, malondialdehyde (MDA) and distribution of plasma long-chain fatty acids (C12-C24) in 28 normal subjects and 24 hypertensive patients. Also, the correlation among PUFAs, levels of antioxidant status, and lipid profiles of the subjects were estimated. Results: The distribution of ${\omega}$-3 PUFAs, saturated fatty acids, and monounsaturated fatty acids showed significant differences (P<0.05), but that of ${\omega}$-6 PUFAs did not exhibit significant differences. The ${\omega}-6/{\omega}-3$ ratio exhibited 36.96 in normal group and 14.29 in the hypertensive patient group. The levels of vitamin A, vitamin E, and MDA were increased significantly in the hypertensive patient group. Conclusion: PUFA levels were estimated in the hypertensive patients and normal group. The results suggest that dietary intake of proper ${\omega}-6/{\omega}-3$ ratio is needed for prevention and treatment of hypertension.

Keywords

References

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