대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

Phenylhydrazine으로 유발된 흰쥐의 용혈성 빈혈에 미치는 삼칠근(三七根)의 효과

A Study about Inhibitory Effects of Panax notoginseng on Hemolytic Anemia

  • 이재열 (경희대학교 한의과대학 간계내과학교실) ;
  • 이장훈 (경희대학교 한의과대학 간계내과학교실)
  • Lee, Jae-Youl (Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Jang-Hoon (Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University)
  • 발행 : 2011.03.30
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초록

Objectives : This study was performed in order to investigate the effect of Panax notoginseng(SCG) on phenylhydrazine (PHZ)-induced hemolytic anemia in rats. Materials and Methods : Rats were divided equally into 3 groups (Normal, Control, SCG). Anemic model rats (Control, SCG) were induced by the treatment of PHZ (40mg/kg/day, i.p.) for 3 days. Red blood cell, hemoglobin, reticulocyte count, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were determined on days 0, 4, 7 and 10. Body weight was investigated on days 0, 2, 4, 6, 8, 10 and weight of spleen was measured on day 10. Results : In the SCG group, significantly higher levels of RBC was found on day 4 and higher concentration of Hb on days 4, 7 and 10. Furthermore, reticulocyte count was dramatically lower on day 10 compared to the control group. Conclusions : These results suggest that SCG may be beneficial in the treatment of hemolytic anemia.

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참고문헌

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