YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis and ${\alpha}$-Glucosidase Inhibitory Activity of Phenylalkyl Piperazine Analogues

페닐알킬 피페라진 유도체 합성과 ${\alpha}$-Glucosidase 저해활성

  • Chang, In-Hye (College of Pharmacy, Catholic University of Daegu) ;
  • Lee, Eun-Young (College of Pharmacy & Division of Life & Pharmaceutical Sciences, Ewha Womans University) ;
  • HwangBo, Kyoung (Pharmaceutical Standardization Research and Testing Division, National Institute of Food and Drug Safety Evaluation) ;
  • Kim, In-Kyu (College of Pharmacy, Yeungnam University) ;
  • Sohn, Kyung-Hee (College of Pharmacy, Yeungnam University) ;
  • Choi, Lan (College of Pharmacy, Yeungnam University) ;
  • Lee, Eung-Seok (Pharmaceutical Standardization Research and Testing Division, National Institute of Food and Drug Safety Evaluation) ;
  • Woo, Mi-Hee (College of Pharmacy, Catholic University of Daegu) ;
  • Son, Jong-Keun (Pharmaceutical Standardization Research and Testing Division, National Institute of Food and Drug Safety Evaluation) ;
  • Na, Young-Hwa (College of Pharmacy, CHA University)
  • 장인혜 (대구가톨릭대학교 약학대학) ;
  • 이은영 (이화여자대학교 약학대학) ;
  • 황보경 (영남대학교 약학대학) ;
  • 김인규 (식품의약품안전평가원 의약품규격연구과) ;
  • 손경희 (식품의약품안전평가원 의약품규격연구과) ;
  • 최란 (식품의약품안전평가원 의약품규격연구과) ;
  • 이응석 (영남대학교 약학대학) ;
  • 우미희 (대구가톨릭대학교 약학대학) ;
  • 손종근 (영남대학교 약학대학) ;
  • 나영화 (차의과학대학교 약학대학)
  • Received : 2011.10.26
  • Accepted : 2011.11.18
  • Published : 2011.12.31
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Abstract

As an effort to find a new scaffold for ${\alpha}$-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their ${\alpha}$-glucosidase inhibitory activities. Compounds 8 ($IC_{50}=2.73{\pm}0.075mM$) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to ${\alpha}$-glucosidase. The result indicated that proper substituents on the piperazine can engender ${\alpha}$-glucosidase inhibitory activities on the piperazine derivatives.

Keywords

References

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