YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of 8-Aryloxycaffeines and Their Inhibitory Activities on Topoisomerase II

8-아릴옥시카페인의 합성과 그 Topoisomerase II 저해활성

  • Received : 2011.10.06
  • Accepted : 2011.10.26
  • Published : 2011.12.31
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Abstract

A series of 8-(substituted)aryloxy- and 8-alkyloxy-caffenines were prepared from 8-bromocaffeine and (substituted) phenols as well as alkanols by Ullmann reaction and their inhibitory activities on topoisomerase II were evaluated. A compound, 8-(quinolin-2-yl)oxycaffeine showed the strongest inhibitory activity against topoisomerase II.

Keywords

References

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