Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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The Association of Obesity, Airway Hyperresponsiveness and Atopy in Chronic Cough Patients: Results of a Two-Center Study

만성 기침환자에서 기관지 과민성, 아토피와 비만의 상관관계: 두 기관 연구

  • Park, So-Yong (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hallym University College of Medicine) ;
  • Park, Jong-Won (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hallym University College of Medicine) ;
  • Oh, Yeon-Mok (Department of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Rhee, Yang-Keun (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,Chonbuk National University Medical School) ;
  • Lee, Young-Mok (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Park, Yong-Bum (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hallym University College of Medicine) ;
  • Lim, Seong-Yong (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine) ;
  • 박소영 (한림대학교 의과대학 내과학교실) ;
  • 박종원 (한림대학교 의과대학 내과학교실) ;
  • 오연목 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 이양근 (전북대학교 의과대학 내과학교실) ;
  • 이영목 (순천향대학교 의과대학 내과학교실) ;
  • 박용범 (한림대학교 의과대학 내과학교실) ;
  • 임성용 (성균관대학교 의과대학 강북삼성병원 내과학교실) ;
  • 천식연구회 (천식연구회)
  • Received : 2011.04.28
  • Accepted : 2011.06.24
  • Published : 2011.07.30
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Abstract

Background: The rising prevalence of asthma worldwide may be associated with the rising prevalence of obesity in developed nations. Although several studies have suggested a relationship between asthma and obesity, controversy still remains. The aim of this study was to examine the relationship between obesity and asthmatic factors such as atopy, eosinophilia, serum total Ig E and bronchial hyperresponsiveness in chronic cough patients. Methods: This study was a retrospective, observational study in two centers done between January 2007 and June 2008. The subjects included individuals who had a chronic cough. We examined body mass index (BMI) to measure obesity and pulmonary function. We did a metacholine provocation test for airway hyperresponsiveness (AHR), a skin prick test for atopy, and tests for blood eosinophils and serum IgE. Results: A total of 1022 subjects were included. Airway hyperresponsiveness was not related with obesity (p=0.06), and atopy incidence was significant higher in non obese patients (p=0.00). There was no significant difference in serum IgE and blood eosinophil counts between obese and non obese patients. Forced expiratory volue in one second ($FEV_1$)/forced vital capacity (FVC) was significantly reduced in obese patients (p=0.03), but FEV1 and FVC were no significant difference between obese and non obese patients. Conclusion: There is no relationship between obesity and bronchial hyperresponsiveness. The nonobese group appears to have more atopy. The relationship between obesity and bronchial hyperresponsiveness and atopy need further investigation.

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References

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