Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Oxaliplatin Induced Angioedema in a Rectal Cancer Patient: A Clinical Case Report

직장암 환자에서 Oxaliplatin 투여로 인한 혈관부종 발생 증례 보고

  • Noh, Mi-Hee (Department of Pharmacy, Bucheon St. Mary's Hospital, The Catholic University of Korea) ;
  • Lee, Yu-Jeung (Graduate School of Clinical Pharmacy, Sookmyung Women's University)
  • 노미희 (부천성모병원 약제팀) ;
  • 이유정 (숙명여자대학교 임상약학대학원)
  • Received : 2011.10.21
  • Accepted : 2011.11.22
  • Published : 2011.12.31
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Abstract

We report an unusual case of angioedema induced by intravenous oxaliplatin in a patient with rectal cancer. Intravenous oxaliplatin was administered to the patient according to FOLFOX regimen (oxaliplatin/leucovorin/5-fluorouracil) for the management of his colorectal carcinoma. The patient had been on FOLFOX regimen for several months without reporting any adverse effects, but he experienced angioedema suddenly during his $9^{th}$ cycle of chemotherapy. Angioedema was observed about 2 hours after the initiation of oxaliplatin infusion. Oxaliplatin was stopped then the patient became stable. This case report demonstrates that intravenous oxaliplatin may induce angioedema several hours after the initiation of oxaliplatin infusion in later cycles of chemotherapy.

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