Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제37권1호
  • /
  • Pages.72-76
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  • 2011
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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구개부에 발생한 다형성 저등급 선암종의 치험례

Polymorphous low-grade adenocarcinoma on hard palate: case report

  • 신영민 (경북대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 최소영 (경북대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김진욱 (경북대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 변기정 (울산대학교병원 치과) ;
  • 김진수 (경북대학교 치의학전문대학원 구강악안면외과학교실)
  • Shin, Young-Min (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Choi, So-Young (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Kim, Jin-Wook (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Byeon, Ki-Jung (Department of Dentistry, Ulsan University Hospital) ;
  • Kim, Chin-Soo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University)
  • 투고 : 2010.09.30
  • 심사 : 2011.01.28
  • 발행 : 2011.02.28
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초록

Polymorphous low-grade adenocarcinomas (PLGA) are distinctive salivary gland neoplasms with a propensity to arise from the minor salivary glands. The most frequent location of PLGA is the palate, even though other locations have been described. Previously used terms for PLGA include lobular carcinoma and terminal duct carcinoma. Although the frequency of the tumor is unknown, the recognition of PLGA as an individual tumor has increased with the establishment of specific histopathological criteria characterizing the PLGA. The first choice of treatment is a wide surgical excision including the subjacent bone if necessary. The prognosis is generally good and the recurrence rate ranges from 17% and 22%. Distant metastases is unusual (9%) but occur mainly in the regional lymph nodes. This is a case report of a 67 year old female patient with PLGA who was treated with a wide excision by layers (2 stage) of the lesion including the surrounding bone. We present this case with a review of the relevant literature.

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참고문헌

  1. Furuse C, Tucci R, Machado de Sousa SO, Rodarte Carvalho Y, Cavalcanti de Araujo V. Comparative immunoprofile of polymorphous low-grade adenocarcinoma and canalicular adenoma. Ann Diagn Pathol 2003;7:278-80. https://doi.org/10.1016/S1092-9134(03)00084-4
  2. Freedman PD, Lumerman H. Lobular carcinoma of intraoral minor salivary gland origin. Report of twelve cases. Oral Surg Oral Med Oral Pathol 1983;56:157-66. https://doi.org/10.1016/0030-4220(83)90282-7
  3. Frierson HF Jr, Mills SE, Garland TA. Terminal duct carcinoma of minor salivary glands. A nonpapillary subtype of polymorphous low-grade adenocarcinoma. Am J Clin Pathol 1985;84:8-14. https://doi.org/10.1093/ajcp/84.1.8
  4. Castle JT, Thompson LD, Frommelt RA, Wenig BM, Kessler HP. Polymorphous low grade adenocarcinoma: a clinicopatho-logic study of 164 cases. Cancer 1999;86:207-19. https://doi.org/10.1002/(SICI)1097-0142(19990715)86:2<207::AID-CNCR4>3.0.CO;2-Q
  5. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. 2nd ed. Philadelphia: WB Saunders; 2002.
  6. Clayton JR, Pogrel MA, Regezi JA. Simultaneous multifocal polymorphous low-grade adenocarcinoma. Report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;80:71-7. https://doi.org/10.1016/S1079-2104(95)80019-0
  7. Kelsch RD, Bhuiya T, Fuchs A, Gentile P, Kahn MA, Fantasia JE. Polymorphous low-grade adenocarcinoma: flow cytometric, p53, and PCNA analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:391-9. https://doi.org/10.1016/S1079-2104(97)90037-8
  8. Darling MR, Schneider JW, Phillips VM. Polymorphous lowgrade adenocarcinoma and adenoid cystic carcinoma: a review and comparison of immunohistochemical markers. Oral Oncol 2002;38:641-5. https://doi.org/10.1016/S1368-8375(02)00003-9
  9. Curran AE, White DK, Damm DD, Murrah VA. Polymorphous low-grade adenocarcinoma versus pleomorphic adenoma of minor salivary glands: resolution of a diagnostic dilemma by immunohistochemical analysis with glial fibrillary acidic protein. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:194-9. https://doi.org/10.1067/moe.2001.111306
  10. Miliauskas JR. Polymorphous low-grade (terminal duct) adenocarcinoma of the parotid gland. Histopathology 1991;19:555-7. https://doi.org/10.1111/j.1365-2559.1991.tb01505.x
  11. Haba R, Kobayashi S, Miki H, Hirakawa E, Saoo K, Iwai T, et al. Polymorphous low-grade adenocarcinoma of submandibular gland origin. Acta Pathol Jpn 1993;43:774-8.
  12. Blanchaert RH, Ord RA, Kumar D. Polymorphous low-grade adenocarcinoma of the sublingual gland. Int J Oral Maxillofac Surg 1998;27:115-7. https://doi.org/10.1016/S0901-5027(98)80307-X
  13. de Diego JI, Bernaldez R, Prim MP, Hardisson D. Polymorphous low-grade adenocarcinoma of the tongue. J Laryngol Otol 1996; 110:700-3.
  14. Kumar M, Stivaros N, Barrett AW, Thomas GJ, Bounds G, Newman L. Polymorphous low-grade adenocarcinoma-a rare and aggressive entity in adolescence. Br J Oral Maxillofac Surg 2004;42:195-9.
  15. Mills SE, Garland TA, Allen MS Jr. Low-grade papillary adenocarcinoma of palatal salivary gland origin. Am J Surg Pathol 1984;8:367-74. https://doi.org/10.1097/00000478-198405000-00005
  16. Simpson RH, Pereira EM, Ribeiro AC, Abdulkadir A, Reis-Filho JS. Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. Histopathology 2002;41:250-9. https://doi.org/10.1046/j.1365-2559.2002.01439.x
  17. Pelkey TJ, Mills SE. Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland. Am J Clin Pathol 1999;111:785-91. https://doi.org/10.1093/ajcp/111.6.785
  18. Gibbons D, Saboorian MH, Vuitch F, Gokaslan ST, Ashfaq R. Fine-needle aspiration findings in patients with polymorphous low grade adenocarcinoma of the salivary glands. Cancer 1999;87:31-6. https://doi.org/10.1002/(SICI)1097-0142(19990225)87:1<31::AID-CNCR6>3.0.CO;2-G
  19. Gnepp DR, el-Mofty S. Polymorphous low-grade adenocarcinoma: glial fibrillary acidic protein staining in the differential diagnosis with cellular mixed tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;83:691-5. https://doi.org/10.1016/S1079-2104(97)90321-8
  20. McGregor IA, McGregor FM. Cancer of the face and mouth: pathology and management for surgeons. New York: Churchill Livingstone; 1986.