Acknowledgement
본 연구는 보건복지부 보건의료기술진흥사업의 지원에 의하여 이루어진 것 임(과제번호: A084119).
Mood & Emotion (우울조울병)
- Volume 9 Issue 3
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- Pages.189-193
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- 2011
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- 1738-0960(pISSN)
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- 2671-4655(eISSN)
Interleukin-1β -511C/T Gene Polymorphism and Depression Related to Breast Cancer
Interleukin-1β 유전자 내 -511C/T 단일염기다형성과 유방암 관련 우울증
- Kim, Jae-Min (Department of Psychiatry, Chonnam National University Medical School) ;
- Kang, Hee-Ju (Department of Psychiatry, Chonnam National University Medical School) ;
- Jang, Ji-Eun (Department of Psychiatry, Chonnam National University Medical School) ;
- Kim, Seon-Young (Department of Psychiatry, Chonnam National University Medical School) ;
- Kim, Sung-Wan (Department of Psychiatry, Chonnam National University Medical School) ;
- Shin, Il-Seon (Department of Psychiatry, Chonnam National University Medical School) ;
- Park, Min-Ho (Breast and Endocrine Tumor Clinic, Chonnam National University Hwasun Hospital) ;
- Yoon, Jung-Han (Breast and Endocrine Tumor Clinic, Chonnam National University Hwasun Hospital) ;
- Yoon, Jin-Sang (Department of Psychiatry, Chonnam National University Medical School)
- 김재민 (전남대학교 의과대학 정신과학교실) ;
- 강희주 (전남대학교 의과대학 정신과학교실) ;
- 장지은 (전남대학교 의과대학 정신과학교실) ;
- 김선영 (전남대학교 의과대학 정신과학교실) ;
- 김성완 (전남대학교 의과대학 정신과학교실) ;
- 신일선 (전남대학교 의과대학 정신과학교실) ;
- 박민호 (화순전남대학교병원 유방내분비 종양클리닉) ;
- 윤정한 (화순전남대학교병원 유방내분비 종양클리닉) ;
- 윤진상 (전남대학교 의과대학 정신과학교실)
- Received : 2011.08.08
- Accepted : 2011.09.21
- Published : 2011.10.30
Abstract
Objectives : Pro-inflammatory cytokines are related to the pathophysiology of both cancer and depression, and their secretion is controlled by the transcriptional activity of particular gene polymorphisms. This study aimed to investigate whether interleukin (IL)-1β -511C/T gene polymorphism is associated with depression following mastectomy for breast cancer. Methods : A total of 309 patients with breast cancer were evaluated one week after mastectomy, and 244 (79%) were followed one year later. Depression (major+minor depressive disorders) was diagnosed according to DSM-IV criteria using the Mini International Neuropsychiatric Interview, and classified into prevalent, persistent, and incident depression. Associations of IL-1β -511C/T polymorphism with the three depressive status were estimated using logistic regression models. Results : At baseline, 74 (24%) patients were classified with prevalent depression ; and at follow up, 19 (8%) and 25 (10%) patients were classified with persistent and incident depression, respectively. The IL-1β -511T/T genotype was independently associated with prevalent and persistent depression, but not with incident depression. Conclusion : IL-1β -511T/T genotype may involve in the etiology of depression occurring in women with breast cancer who receive a mastectomy.
Keywords