The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Antihypertensive Activity and Anti-gout Activity of Mushroom Sarcodon aspratus

능이버섯의 항고혈압 활성과 항통풍 활성

  • Kang, Min-Gu (Department of Life Science and Genetic Engineering, Paichai University) ;
  • Bolormaa, Zanabaatar (Department of Life Science and Genetic Engineering, Paichai University) ;
  • Lee, Jong-Seok (Hospitals of Chungnam Natioal University) ;
  • Seo, Geon-Sik (Korea National College of Agricultural and Fishery) ;
  • Lee, Jong-Soo (Department of Life Science and Genetic Engineering, Paichai University)
  • Received : 2011.03.07
  • Accepted : 2011.03.21
  • Published : 2011.04.01
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Abstract

We collected wild mushroom, Sarcodon aspratus from Deogyu Mt. of Muju, Jeollabuk-do and physiological functionalities of its water extract were investigated. The water extracts from S. aspratus showed the highest antihypertensive angiotensin I-converting enzyme (ACE) inhibitory activity of 74.3% and also showed high anti-gout xanthine oxidase (XOD) inhibitory activity (59.6%). However, tyrosinase inhibitory activity was very low (17.3%), and antioxidant activity and SOD-likely activity were not detected. The ACE inhibitory activity of S. aspratus fruiting body was the highest when powder of the fruiting body was shaked at $30^{\circ}C$ for 24 h by distilled water. Furthermore, the XOD inhibitory activity was also the highest by extraction at $50^{\circ}C$ for 24 h with water.

야생 능이버섯에 함유되어 있는 생리 기능성 물질들을 탐색, 분리하여 이들을 고부가가치의 건강식품 소재로 활용하고자 덕유산 일대에서 채집한 능이버섯의 물 추출물은 제조하여 몇 가지 생리 기능성을 측정하였다. 능이버섯 자실체의 물 추출물은 항고혈압성 엔지오텐신 전환효소(ACE) 저해 활성과 항통풍성 xanthine 산화효소(XOD) 저해활성이 각각 74.3%와 59.6%로 우수하였다. 그러나 tyrosinase 저해 활성과 항산화 활성, SOD 유사활성 등은 매우 낮거나 없었다. 능이버섯 자실체중의 ACE 저해활성은 자실체 분말의 물현탁액을 $30^{\circ}C$에서 24시간, XOD 저해물질은 $50^{\circ}C$에서 24시간 진탕 시켰을 때 가장 높았다. 이들 두 가지 생리활성 물질을 함유한 능이버섯 물 추출물은 앞으로 건강식품이나 대체 의약 소재 개발에 매우 유용하게 활용 할 것으로 사료된다.

Keywords

References

  1. 유영복, 구창덕, 김성환 서건식 신현동 이준우, 이창수, 장현유. 2010. 버섯학. 자연과 사람 (서울 Korea). pp. 385-420.
  2. 박정식, 현광욱, 서승보, 조수묵, 유창현, 이종수. 2003. 버섯으로부터 혈소판 응집억제물질 과 혈전용해물질의 탐색. 한국균학회지 31:114-116.
  3. 이대형, 김재호, 정종천, 공원식, 유영복, 박정식, 유창현, 이종수. 003. 각종 버섯류로부터 안지오텐신 전환효소 저해제의 탐색. 한국균학회지 31:148-154. https://doi.org/10.4489/KJM.2003.31.3.148
  4. 최낙식, 서승염, 김승호. 1996. 혈전용해능을 갖은 버섯류의 탐색. 한국식품 과학회지 31:553-557.
  5. Blois, M. S. 1958. Antioxidant determination by the use of stable free radical. Nature. 191:1199.
  6. Choi, N. S., Seo, S. Y. and Kim, S. H. 1999. Screening of mushrooms having fibrinolytic activity. Kor. J. Food Sci. Technol. 31:553-557.
  7. Cushman D.W. and H.S Cheung. 1971. Spectrophotometic assay and properties of angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20:1637-1648. https://doi.org/10.1016/0006-2952(71)90292-9
  8. Erkel, G. and Anke, T. 1992. Antibiotics from bASI diomycetes XLI, Clavicoronic acid, a novel inhibitor of reverse transcriptase from Clavicorona pyxidate. J. Atibiotics. 45:29-37. https://doi.org/10.7164/antibiotics.45.29
  9. Eun, J. S, Yang, J. H., Cho, D. Y. and Lee, T. K. 1988. Studies on higher fungi in Korea (I) : Activity of proteolytic enzyme from Sarcodon aspratus. J. Kor. Pharm. Sci. 18:125-131
  10. Jang, J. H., Jeong, S. C., Lee, J. H., Ju, Y. C, and Lee, J. S. 2011. Characterization of a new antihypertensive angiotensin I-converting enzyme inhibitory peptide from Pleurotus cornucopiae. Food Chemistry. 127:412-418. https://doi.org/10.1016/j.foodchem.2011.01.010
  11. Jeong, O.J., Yoon, H.S and Min, Y.K. 2001. Aroma characteristics of Neungee (Sarcodon aspratus). Kor. J. Food Sci. Technol. 33:307-312.
  12. Joo, O. S. 2008. Chemical components and physiological activities of neungee mushroom (Sarcodon aspratus). Kor. J. Food Preserv. 15(6):864-871.
  13. Kabir, Y.K., Kimura, S. and Tamura, T. 1998. Dietary effect of Ganoderma lcidum: Mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J. Nutr. Sci. Vitaminol. 34:433-438.
  14. Kang, H.C., Yun, B.S., Yu, S.H and Yoo, I.D. 2000. Chemical structures of the compounds isolated from the edible mushroom Sarcodon aspratus. J. Kor. Soc. Agric. Chem. Biotechnol. 43:298-302.
  15. Kiho, T., Hui, J., Yamane, A. and Ukai, S. 1993. Polysaccharides in fungi. XXXII. Hypoglycemic activity and chemical properties of a polysaccharide from the cultural mycelium of Cordyceps sinensis. Biol. Pharm. Bull. 16:1291-1293. https://doi.org/10.1248/bpb.16.1291
  16. Kiho, T., Yamane, A., Hui, J., Usui, S. and Ukai, S. 1996. Polysaccharides in fungi, XXXVI. Hypoglycemic activity of a polysaccharides (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Biol. Pharm. Bull. 19:294-296. https://doi.org/10.1248/bpb.19.294
  17. Kim, J.W., Moon, B.S., Park, Y.M., Yoo, N.H., Ryoo, I.J., Chinh, N.T., Yoo, I.D. and Kim, J.P. 2005. Structures and antioxidant activity of diketopiperazines isolated from the mushroom Sarcodon aspratus. J. Kor. Soc. Appl.. Biol. Chem. 48:93-97.
  18. Koo, K. C., Lee, D. H., Kim, J. H., Yu, H. E., Park, J. S. and Lee, J. S. 2006. production and characterization of antihypertensive angiotensin I-converting enzyme inhibitor from Phaliota adiposa. J. Microbiol. Biotechnol. 16:757-763.
  19. Lee, D. H., Kim, J. H., Park, J. S., Yoo, C. H. and Lee, J. S. 2004. Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum. Peptide. 25:621-627. https://doi.org/10.1016/j.peptides.2004.01.015
  20. Lee, S.H., Kim, N.W. and Shin, S.R. 2003. Studies on the nutritional components of mushroom (Sarcodon aspratus). Kor. J. Food Preserv. 10:65-69.
  21. Marklund, S. and G. Marklund. 1974 Inolvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47:469-474. https://doi.org/10.1111/j.1432-1033.1974.tb03714.x
  22. Mizuno, T., Kinoshit, T. Zhung, C., Ito, H. and Mayuzumi, Y. 1995. Antitumor activity of heteroglycans from nioushimeji, Tricholoma giganteum. Food Rev. International. 59:563-567.
  23. Muller, W. E. G., Weiler, B. E., Charubala, R. W. and Schroder, H. C. 1990. Cordycepin analogue of 2'5'-oligoadenylate inhibitor of human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochemistry. 30:2027-2033.
  24. Noro. T., Yasushi, O., Toshio, M., Akira, U. and Fukushima, S. 1983. Inhibitors of xanthine oxidase from the flowers and buds of Daphne genkwa., Chem. pharm. Bull. 31:3984. https://doi.org/10.1248/cpb.31.3984
  25. Song, J.H., Lee, H,S., Hwang, J.K., Han, J.W., Ro, J.G., Keum, D.H. and Park, K.M. 2003. Physiological activity of Sarcodon aspratus extracts. Kor. J. Food Sci. Animal Resour. 23:172-179.
  26. Sung, C. K. and S. H, Cho. 1992. Studies on the purification and characteristics of tyrosinase from Diaspyros kaki thunb. Kor. Biochem. J. 25:79-87.

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