안구 영상을 위한 OCT용 손잡이 형 프로브의 개발

Development of Hand-held OCT probe for Ophthalmic Imaging

  • 조남현 (경북대학교 전자전기컴퓨터대학원) ;
  • 정웅규 ;
  • 정운상 (경북대학교 전자전기컴퓨터대학원) ;
  • ;
  • 심재훈 (경북대학교 전자전기컴퓨터대학원) ;
  • 김지현 (경북대학교 전자전기컴퓨터대학원)
  • Cho, Nam-Hyun (Graduate School of Electrical Engineering and Computer Science Kyoungpook National University) ;
  • Jung, Woong-Gyu (Beckman Institute for Advanced Science and Technology, University of Illinois at Ulbana-Champaign) ;
  • Jung, Un-Sang (Graduate School of Electrical Engineering and Computer Science Kyoungpook National University) ;
  • Sephen, A.Boppart (Beckman Institute for Advanced Science and Technology, University of Illinois at Ulbana-Champaign) ;
  • Shim, Jae-Hoon (Graduate School of Electrical Engineering and Computer Science Kyoungpook National University) ;
  • Kim, Jee-Hyun (Graduate School of Electrical Engineering and Computer Science Kyoungpook National University)
  • 투고 : 2010.06.21
  • 심사 : 2010.11.29
  • 발행 : 2011.01.25

초록

본 연구에서는 안구 영상을 위한 OCT용 손잡이 형 프로브를 개발하였다. 프로브는 휴대하기 간편한 손잡이 형태로 구현하였으며, 어댑터의 대물렌즈를 교체함으로써 각막(cornea)과 망막(retina) 모두 영상화 할 수 있도록 설계 하였다. 시스템의 성능검증을 위해 in vivo로 실험용 쥐의 눈 영상을 2D로 획득하였으며, 획득한 영상을 3D 영상으로 재구성하였다. 3D 영상은 쥐의 미세한 부분의 구조를 잘 나타내었으며, 움직임에 의한 흔들림 현상(Motion artifact)이 나타나지 않았으므로 개발된 OCT시스템의 이미지 디스플레이 속도는 생체 내 실험 (in vivo)에 적합함을 알 수 있었다.

We have developed a hand-held probe for an ophthalmic OCT system. The hand-held probe for imaging was designed to be compact and portable. The cornea and retinal images were acquired by replacing the objective lens at the front of the probe. To verify the performance of the hand-held OCT probe, we acquired two dimensional OCT image of the rat eye in vivo and reconstructed three dimensional rat eye rendering images. In vivo 3D OCT images were showed distinct structural information in the posterior and anterior chamber with minimal motion artifacts. Thereby, OCT imaging speed is suitable for an dynamic in vivo experiment.

키워드

참고문헌

  1. Huang. D, E.A.Swanson, Et al. "Optical Coherence Tomography." Science 254: 1178-1181, 1991. https://doi.org/10.1126/science.1957169
  2. Brett E.Bouma, Guiilermo J.Tearney. "Handbook of Optical Coherence Tomography." Marcel Dekker, Inc. 2002.
  3. A.F.Fercher, W.Drexler, C.K.Hitzenberger and T.Lasser, "Optical Coherence tomographyprinciples and applications." Rep.Prog.Phys. 66, 239-303, 2003. https://doi.org/10.1088/0034-4885/66/2/204
  4. J. M. Schmitt, "Optical coherence tomography (OCT): A Review", IEEE J.selected topics in quantum electronics, 5,1205-1215, 2007.
  5. Jeehyun Kim, Bong-Soo Sohn, Thomas E. Milner, "Real-time Retinal Imaging with a parallel optical coherence tomography using a CMOS smart array detector", Journal of the Korean physical society, 51, 1787-1791, 2007. https://doi.org/10.3938/jkps.51.1787
  6. 남상희 "방사선 의료 영상", 대한전자공학회, 전자공학회, 제21권 제12호(통권 제127호), 1230-1239쪽, 1994년.
  7. M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito and J. G. Fujimoto, "Optical coherence tomography of the human retina", Arch Ophthalmol., 113, 325-332, 1995. https://doi.org/10.1001/archopht.1995.01100030081025
  8. Sarah Muscat, Nicola Mckay, Stuart Parks, Ewan Kemp and David Keating, "Repeatability and Reproducibility of Corneal Thickness Measurements by Optical Coherence Tomography", Invest. Ophthalmol. Vis. Sci., 43, 1791-1795, 2002.
  9. Thilo Gambichler, Geprg Moussa, Michael Sand, Daniel Sand, Peter Alimeyer and Klaus Hoffmann, "Application of optical coherence tomography", J. Dermatol., 40,85-94, 2005.
  10. Masanori Hangai, Motoshi Yamamoto, Atsushi Sakamoto, Nagaahisa Yoshimura, "Ultrahighresolution versus speckle noise reduction in spectral-domain optical coherence tomography" optics Express, 5, 4221-4235, 2009.
  11. Yoshifumi Nakamura, shuichi makita, Yoshiaki Yasuno "High-speed three-dimansional human retinal imaging by line-field spectral domain optical coherence tomography", optics Express, 12, 7103-7116, 2007.
  12. Yoshifumi Nakamura, shuichi makita, Yoshiaki Yasuno "High-speed three-dimansional human retinal imaging by line-field spectral domain optical coherence tomography", optics Express, 12, 7103-7116, 2007.
  13. Nader Nassif, Barry Cense, B.Hyle Park, Seok H.Yun "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography", optics letters, 29, 5 march 1, 2004.
  14. W.S. Royce, Chen, BA Jay S., Duker, Viv다 Srinivasan, G.James, Fujimoto "Speed and Resolution Improve in Newest OCT", Review of Opthalmology, pp.84-88, July 2007.