Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Analysis of Gender Differences in Physician's Desk Reference

Physician's Desk Reference에 나타난 성별차이 분석

  • Heo, Jung-Sun (Graduate School of Clinical Health Sciences, Ewha Womans University) ;
  • Kim, Kyung-Hee (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University) ;
  • Yoon, In-Kyung (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University) ;
  • Kim, Hyun-Ju (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University) ;
  • Kim, You-Jin (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University) ;
  • Choi, Jong-Min (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University) ;
  • Lee, Byeong-Gu (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University) ;
  • Lee, Hwa-Jeong (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University) ;
  • Gwak, Hye-Sun (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University)
  • 허정선 (이화여자대학교 임상보건과학대학원) ;
  • 김경희 (이화여자대학교 약학대학/생명약학부) ;
  • 윤인경 (이화여자대학교 약학대학/생명약학부) ;
  • 김현주 (이화여자대학교 약학대학/생명약학부) ;
  • 김유진 (이화여자대학교 약학대학/생명약학부) ;
  • 최종민 (이화여자대학교 약학대학/생명약학부) ;
  • 이병구 (이화여자대학교 약학대학/생명약학부) ;
  • 이화정 (이화여자대학교 약학대학/생명약학부) ;
  • 곽혜선 (이화여자대학교 약학대학/생명약학부)
  • Received : 2010.10.01
  • Accepted : 2011.01.02
  • Published : 2011.03.31
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Abstract

Purpose: This study aims to investigate how gender-based differences are actually reflected on drug approval. Methods: Data on gender-based differences of drugs were analyzed by searching PDR (Physician's Desk Reference) with the keyword, "GENDER". Results: There were descriptions related to gender in product directions of 361 drugs in 2009 PDR, out of which 63 items actually showed gender-related differences. Drug categories showing comparatively high gender-based differences were nervous system, cardiovascular system, and alimentary tract and metabolism. Pharmacokinetic differences between genders were observed most frequently; compared to men, 32 drugs showed higher absorption while 18 drugs revealed lower clearance in women. There were 2 drugs which gender should be considered before prescribing, and 5 drugs which showed different severity of adverse effects according to gender. Conclusions: It is necessary to establish domestic policies for drug approval and use which reflects gender-based differences through sufficient researches.

Keywords

References

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