Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Clinical Features and the Risk Factors of Distant Metastasis in Locally Advanced Advanced Head and Neck Cancer Patients after Induction Chemotherapy Followed Locoregional Control Therapy

유도화학요법 및 국소 치료 후 원격전이를 보인 국소 진행성 두경부암 환자군의 임상 특징 및 위험인자에 관한 연구

  • Lee, Hye-Won (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Baek, Dong-Hoon (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Lee, Kyung-Nam (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Cho, Eun-Jung (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Kim, Hyo-Jeong (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Seol, Young-Mi (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Song, Moo-Kon (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Choi, Young-Jin (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Shin, Ho-Jin (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Chung, Joo-Seop (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Cho, Goon-Jae (Department of Internal Medicine, Pusan National University School of Medicine)
  • 이혜원 (부산대학교 의학전문대학원 내과학교실) ;
  • 백동훈 (부산대학교 의학전문대학원 내과학교실) ;
  • 이경남 (부산대학교 의학전문대학원 내과학교실) ;
  • 조은정 (부산대학교 의학전문대학원 내과학교실) ;
  • 김효정 (부산대학교 의학전문대학원 내과학교실) ;
  • 설영미 (부산대학교 의학전문대학원 내과학교실) ;
  • 송무곤 (부산대학교 의학전문대학원 내과학교실) ;
  • 최영진 (부산대학교 의학전문대학원 내과학교실) ;
  • 신호진 (부산대학교 의학전문대학원 내과학교실) ;
  • 정주섭 (부산대학교 의학전문대학원 내과학교실) ;
  • 조군제 (부산대학교 의학전문대학원 내과학교실)
  • Received : 2011.08.05
  • Accepted : 2011.10.11
  • Published : 2011.11.25
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Abstract

Backgrounds : Head and neck cancer is one of the most prevalent cancers in the world. It tends to remain localized at the primary site and regional lymph nodes, but if distant metastasis occurs, it has a poor prognosis. This study was performed to evaluate the prevalence of distant metastasis and to determine the risk factor in locally advanced head and neck cancer after induction chemotherapy followed locoregional control therapy. Methods : A retrospective review was performed in 420 patients with locally advanced head and neck cancer who treated with induction chemotherapy followed locoregional control therapy from January 2001 to December 2010. Among them, 31 patients who had distant metastasis as first relapse within 2 years after termination of therapy were analyzed for clinical features and the risk factors of distant metastasis. Results : The overall incidence of distant metastasis was 7.3%. The bone, lung, and liver were the most frequent metastatic organs. In univariate analysis, nodal stage, nasopharyngeal cancer, laryngeal cancer, G3/G4 neutropenia during induction chemotherapy, and concurrent chemoradiotherapy were the influencing factors for distant metastasis. In multivariate analysis, advanced N stage and nasopharynx were the risk factors of distant metastasis, and grade 3/4 neutropenia during induction chemotherapy was considered to decrease distant metastasis. Conclusion : This study suggests that the advanced N stage is the risk factor of distant metastasis and Grade 3/4 neutropenia during induction chemotherapy can be beneficial against distant metastasis in locally advanced head and neck cancer patients treated with induction chemotherapy followed locoregional control therapy.

Keywords

References

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