Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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A Case Report on the Jaundice Occurred during the Modified Fasting Therapy Period : The Gilbert's Syndrome

절식기간 중 Gilbert 증후군으로 황달이 발생한 증례보고 1례

  • Chung, Won-Suk (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Hyun-Kun (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Choi, Hyo-Jeong (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Sung-Su (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung-Hee University)
  • 정원석 (경희대학교 한의과대학 한방재활의학과교실) ;
  • 박현건 (경희대학교 한의과대학 한방재활의학과교실) ;
  • 최효정 (경희대학교 한의과대학 한방재활의학과교실) ;
  • 김성수 (경희대학교 한의과대학 한방재활의학과교실)
  • Received : 2011.12.13
  • Accepted : 2011.12.22
  • Published : 2011.12.30
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Abstract

Objectives: The modified fasting therapy(MFT) of traditional korean medicine uses very low calorie diet on a patient with chronic disease and obesity. During the fasting period of MFT, calorie intake is restricted under 600kcal. Adverse events such as hunger, heartburn, headache, and hair loss can occur because of fasting. In case of Gilbert's syndrome, Jaundice can arise without disorder of liver function and hemolysis because of increase of unconjugated bilirubin. We experienced a case of Gilbert's syndrome patient who appeared jaundice during the fasting period, so we report about that with literature review.

절식요법은 일정기간 섭취 칼로리를 제한하여 질병을 치료하는 방법이다. 600kcal이하로 칼로리를 제한하는 절식기에는 공복감, 속쓰림, 두통, 탈모 등의 여러 가지 증상들이 발생할 수 있으며, 길버트 증후군 환자에서는 특별한 간기능의 이상이나 용혈 없이 비포합 빌리루빈의 증가로 인한 황달이 나타날 수 있다. 이 증례보고서에서는 절식요법의 절식기에 황달이 발생한 길버트 증후군 환자 1례를 경험하여 문헌고찰과 함께 보고하였다.

Keywords

References

  1. 한방재활의학과학회. 한방재활의학 2판. 서울:군자출판사. 2005:376-84.
  2. 이수경, 진신영, 박성철, 김선종, 임양의, 송용선. 절식요법이 비만환자의 체성분변화에 미치는 영향. 대한한방비만학회지. 2000;10(1):79-86.
  3. 신승우, 김성수, 신현대. 절식요법의 체중감량 효과와 체성분변화에 대한 관찰. 대한한방비만학회지. 2003;3(1):25-35.
  4. Kasper et al., Harrison's Principles of Internal Medicine, 16th edition, McGraw-Hill 2005
  5. Boon et al., Davidson's Principles & Practice of Medicine, 20th edition, Churchill Livingstone 2006
  6. Raijmakers MT, Jansen PL, Steegers EA, Peters WH. "Association of human liver bilirubin UDPglucuronyltransferase activity, most commonly due to a polymorphism in the promoter region of the UGT1A1 gene". Journal of Hepatology. 2000;33 (3): 348-351. https://doi.org/10.1016/S0168-8278(00)80268-8
  7. a b Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GN, Jansen PL, Oude Elferink RP, et al. "The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome". New England Journal of Medicine. 1995; 333(18):1171-5. https://doi.org/10.1056/NEJM199511023331802
  8. Monaghan G, Ryan M, Seddon R, Hume R, Burchell B. "Genetic variation in bilirubin UPDglucuronosyltransferase gene promoter and Gilbert's syndrome". Lancet. 1996;347 (9001): 578-81. https://doi.org/10.1016/S0140-6736(96)91273-8
  9. Bancroft JD, Kreamer B, Gourley GR. "Gilbert syndrome accelerates development of neonatal jaundice". Journal of Pediatrics. 1998;132 (4): 656-60. https://doi.org/10.1016/S0022-3476(98)70356-7
  10. Cappellini MD, Di Montemuros FM, Sampietro M, Tavazzi D, Fiorelli G. "The interaction between Gilbert's syndrome and G6PD deficiency influences bilirubin levels". British journal of haematology. 1999;104 (4): 928-9. https://doi.org/10.1111/j.1365-2141.1999.1331a.x
  11. a b Olsson R, Bliding A, Jagenburg R, Lapidus L, Larsson B, Svärdsudd K, Wittboldt S. "Gilbert's syndrome--does it exist? A study of the prevalence of symptoms in Gilbert's syndrome". Acta Med Scandinavia. 1988;224 (5): 485-490.
  12. Bailey A, Robinson D, Dawson AM. "Does Gilbert's disease exist?". Lancet. 1977;1(8018): 931 -3.
  13. J L Gollan, C Bateman, B H Billing. "Effect of dietary composition on the unconjugated hyperbilirubinaemia of Gilbert's syndrome". Gut. 1976; 17(5): 335-340. https://doi.org/10.1136/gut.17.5.335
  14. N Carulli, M Ponz de Leon, E Mauro, F Manenti, A Ferrari. "Alteration of drug metabolism in Gilbert's syndrome". Gut. 1976;17 (8): 581-587. https://doi.org/10.1136/gut.17.8.581
  15. Martin Black , Sheila Sherlock. TREATMENT OF GILBERT'S SYNDROME WITH PHENOBARBITONE. The Lancet. 1970;295(7661):1359 - 1362 https://doi.org/10.1016/S0140-6736(70)91269-9
  16. 육창수, 강성길. 황달치료에 있어서 Artemisia Genus의 임상. Korean Journal of Clinical Pharmacy. 1991;1(1):37-39.