Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Successful Carboplatin Chemotherapy for Oral Fibrosarcoma in the Buccal Mucosa of a Dog

개의 구강점막에 발생한 구강 섬유육종에서 카보플라틴의 성공적인 항암치료 효과

  • Jung, Dong-In (Research Institute of Life Sciences, Gyeongsang National University) ;
  • Kim, Ju-Won (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Lim, Chae-Young (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Han, Sung-Kuk (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Ha-Jung (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-Myung (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 정동인 (경상대학교 생명과학연구원) ;
  • 김주원 (건국대학교 수의과대학) ;
  • 임채영 (건국대학교 수의과대학) ;
  • 한성국 (건국대학교 수의과대학) ;
  • 김하정 (건국대학교 수의과대학) ;
  • 박희명 (건국대학교 수의과대학)
  • Accepted : 2011.09.09
  • Published : 2011.12.31
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Abstract

An 11-year-old castrated male cocker spaniel presented with halitosis, anorexia, and swelling of the left face. Upon physical examination, a firm mass was detected in the left buccal mucosa. Fine needle aspiration cytology revealed a malignant tumor of mesenchymal origin. We performed biopsy, which gave a diagnosis of oral fibrosarcoma. The client refused surgical treatment, and carboplatin chemotherapy (300 $mg/m^2$, IV, q 21 days) was initiated. The mass gradually decreased in size and disappeared about 89 days after the initial chemotherapy. Complete remission was attained, and the tumor did not relapse. This case report shows that a single carboplatin chemotherapy session can achieve macroscopic complete remission of oral fibrosarcoma.

11년 령의 중성화된 수컷 코커 스파니엘견이 구취, 식욕부진과 좌측 안면부의 부종 증상을 보여 내원하였다. 신체 검사 상에서 좌측 구강점막의 단단한 종괴가 확인되었다. 가는 침 흡인 세포검사 결과 악성의 중간엽 유래 종양이 가장 의심되어 생검을 실시하였고 조직검사 결과 섬유육종으로 진단되었다. 보호자의 거부로 수술적인 치료가 아닌 카보플라틴 (carboplatin, 300 $mg/m^2$, IV, q 21 days)을 이용한 항암치료를 실시하였다. 항암치료 시작 후 육안적으로 종양의 크기가 현저히 줄어들어 약 89일 후에는 육안적으로 완전 경감되었다. 총 4회의 항암치료 이후 항암치료를 중단하였고 종양의 재발은 일어나지 않았다. 본 증례보고는 개의 구강 섬유육종에서 carboplatin을 이용한 항암 치료가 육안적인 종양의 완전 경감을 유도할 수 있음을 보여준다.

Keywords

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