Single Incision Flexible Endoscopic Cholecystectomy in Dogs : Feasibility Study

개에서 단일 통로 유연 내시경 담낭 절제술 : 유용성 연구

  • Lee, So-Yeon (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Shin, Beom-Jun (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Jeong, Seong-Mok (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University)
  • 이소연 (충남대학교 수의과대학.동물의과학 연구소) ;
  • 신범준 (충남대학교 수의과대학.동물의과학 연구소) ;
  • 정성목 (충남대학교 수의과대학.동물의과학 연구소)
  • Accepted : 2011.12.13
  • Published : 2011.12.31

Abstract

Laparoscopic surgery is a well-established alternative to open surgery across disciplines. However, in veterinary medicine, laparoscopic surgery in dogs was rarely reported because of small abdominal size for multiple ports insertion. The concept of single-incision laparoscopic surgery (SILS) is to perform the entire laparoscopic operation through a single incision rather than conventional multiple small skin incisions. Indirect evidence of potential benefits of SILS, decreases operative morbidity related to reduction in port size, already exists. Therefore, this study was performed to evaluate the safety and feasibility of the modified form of SILS using flexible endoscope in Cholecystectomy before clinical adoption. A 2 cm single periumbilical incision was performed, and flexible endoscope was introduced into the abdominal cavity. A laparoscopic grasper was inserted into the abdominal cavity for the traction of gall bladder. Cystic duct and artery were ligated by 5 mm Hem-o-lok$^{(R)}$. Then, gall bladder was dissected and resected from the liver with 5 mm Autonomy Laparo-Angle Maryland dissector and endoscopic needle knife. Resected gall bladder was wrapped by using specimen pouch and was retrieved through abdominal incision from the cavity. All three gall bladders were successfully removed. Hematological changes were not observed during examination periods. No leakage sign was identified at necropsy. The flexible endoscope, as distinct from conventional rigid laparoscope, allows the visualization from various angles and the wide range of motion, result in less crowding.

본 연구에서는 중 소형견에서 1개의 복강경 통로를 통한 내시경적 담낭 제거술을 실시함으로써, 개에서 최소 침습적 수술로 담낭 절제술을 실시할 수 있는 방법을 확립하기 위하여 실시하였다. 실험 동물로 총 3마리의 수컷 비글견 ($10.3{\pm}0.62$ kg)을 이용하였으며 배꼽 주위에 하나의 절개창을 만든 후 단일 통로 내시경 시스템을 장착하였다. 이 시스템을 통해 내시경과 Maryland 복강경용 겸자로 담낭을 견인, 제거하였다. 3마리 모두 성공적으로 담낭 절제술을 실시하였으며, 수술 후 감염과 같은 합병증은 발생하지 않았다. 또한 술전, 술후를 비교한 혈액, 혈청 검사상에서도 특이적인 소견은 관찰되지 않았다. 술후 7일 후에 이루어진 부검 소견에서도 출혈 및 담즙의 유출 및 복막염 등과 같은 부작용은 관찰되지 않았다. 따라서 본 연구를 통해, 단일 통로를 이용한 내시경 유도하 담낭 절제술은 중소형견에서 실시할 수 있는 복강 수술 방법 중 최소한의 절개를 통해 비침습적으로 이루어질 수 있는 유용한 수술 방법이라 할 수 있다.

Keywords

References

  1. Aguirre AL, Center SA, Randolph JF, Yeager AE, Keengan AM, Harvey HJ, Erb HN. Gallbladder disease in Shetland sheepdogs: 38 cases (1995-2005). J Am Vet Med Assoc 2007; 231: 79-88. https://doi.org/10.2460/javma.231.1.79
  2. Andrei VE, Schein M, Margolis M, Rucinski JC, Wise L. Liver enzymes are commonly elevated following laparoscopic cholecystectomy: is elevated intra-abdominal pressure the cause? Dig Surg 1998; 15: 256-259. https://doi.org/10.1159/000018624
  3. Besso JG, Wrigley RH, Gliatto JM, Webster CR. Ultrasonographic appearance and clinical findings in 14 dogs with gallbladder mucocele. Vet Radiol Ultrasound 2000; 41: 261-271. https://doi.org/10.1111/j.1740-8261.2000.tb01489.x
  4. Boni L, Benevento A, Rovera F, Dionigi G, Di Giuseppe M, Bertoglio C, Dionigi R. Infective complications in laparoscopic surgery. Surg Infect (Larchmt) 2006; 7: S109-111.
  5. Chamberlain RS, Sakpal SV. A comprehensive review of single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) techniques for cholecystectomy. J Gastrointest Surg 2009; 13: 1733-1740. https://doi.org/10.1007/s11605-009-0902-y
  6. Cheah WK, Lenzi JE, So JB, Kum CK, Goh PM. Ran-domized trial of needlescopic versus laparoscopic cholecystectomy. Br J Surg 2001; 88: 1017-1018.
  7. Chow A, Purkayastha S, Paraskeva P. Appendicectomy and cholecystectomy using single-incision laparoscopic surgery (SILS): The first UK experience. Surg Innov 2009; 16: 211-217. https://doi.org/10.1177/1553350609344413
  8. Church EM, Mathleson JR. Surgical treatment of 23 dogs with necrotizing cholecystitis. J Am Anim Hosp Assoc 1988; 24: 305-310.
  9. Culp WTN, Mayhew PD, Brown DC. The effect of laparoscopic versus open ovariectomy on post-operative activity in small dogs. In: Proceedings of the 2008 ACVS Veterinary Symposium. San Diego; 2008: P6.
  10. Cuschieri A, Dubois F, Mouiel J, Mouret P, Becker H, Buess G, Trede M, Troidl H. The European experience with laparoscopic cholecystectomy. Ann J Surg 1991; 161: 385-387. https://doi.org/10.1016/0002-9610(91)90603-B
  11. Devitt CM, Cox RE, Hailey JJ. Duration, complications, stress and pain of open ovariohysterectomy versus a simple method of laparoscopic-assisted ovariohysterectomy in dogs. J Am Vet Med Assoc 2005; 227: 921-927. https://doi.org/10.2460/javma.2005.227.921
  12. Eich CS, Ludwig LL. The surgical treatment of cholelithiasis in cats: a study of nine cases. J Am Anim Hosp Assoc 2002; 38: 290-296. https://doi.org/10.5326/0380290
  13. Giacomo U, Alfonso MM, Gioacchino C, Gaspere G, David B, Arianna CS. Laparoscopic cholecystectomy: European position versus American position. Revisata de Ciencia de Saude de Macau 2002; 3: 32-34.
  14. Giraudo G, Brachet CR, Caccetta M, Morino M. Gasless laparoscopy could avoid alterations in hepatic function. Surg Endosc 2001; 15: 741-746. https://doi.org/10.1007/s004640090020
  15. Hasukic S, Kosuta D, Muminhodzic K. Comparison of postoperative hepatic function between laparoscopic and open cholecystectomy. Med Princ Pract 2005; 14: 147-150. https://doi.org/10.1159/000084630
  16. Hasukic S. Postoperative change in liver function test: randomized comparison of low- and high-pressure laparoscopic cholecystectomy. Surg Endosc 2005; 19: 1451-1455. https://doi.org/10.1007/s00464-005-0061-5
  17. Jakimowicz J, Stultiëns G, Smulders F. Laparoscopic insufflation of the abdomen reduces portal venous flow. Surg Endosc 1998; 12: 129-132. https://doi.org/10.1007/s004649900612
  18. Kagaya T. Laparoscopic cholecystectomy via two ports, using the "Twin-Port" system. J Hepatobiliary Pancreat Surg 2001; 8: 76-80. https://doi.org/10.1007/s005340170053
  19. Keus F, de Jong JA, Gooszen HG, van Laarhoven CJ. Laparoscopic versus open cholecystectomy for patient with symptomatic cholecystolithiasis. Cochrane Database Syst Rev 2006; 4: CD006231.
  20. Kirpensteijin J, Fingland RB, Ulrich T, Sikkema DA, Allen SW. Cholelithiasis in dogs: 29 cases (1980-1990). J Am Vet Med Assoc 1993; 202: 1137-1142.
  21. Kuhry E, Schwenk W, Gaupset R, Romild U. Bonjer J. Longterm outcome of laparoscopic surgery for colorectal cancer: a Cochrane systematic review of randomized controlled trials. Cancer Treat Rev 2008; 34: 498-504. https://doi.org/10.1016/j.ctrv.2008.03.011
  22. Lee J, EI-Tamer M, Schifftner T, Turrentine FE, Henderson WG, Khuri S, Hanks JB, Inabnet WB. Open and laparoscopic adrenalectomy: analysis of the national surgical quality improvement program. J Am Coll Surg 2008; 206: 953-959. https://doi.org/10.1016/j.jamcollsurg.2008.01.018
  23. Marescaux J, Dallemagne B, Perretta S, Wattiez A, Mutter D, Coumaros D. Surgery without scars: report of transluminal cholecystectomy in a human being. Arch Surg 2007; 142: 823-826. https://doi.org/10.1001/archsurg.142.9.823
  24. Mayhew PD. Advanced laparoscopic procedures (hepatobiliary, endocrine) in dogs and cats. Vet Clin North Am Small Anim Pract 2009; 39: 925-939. https://doi.org/10.1016/j.cvsm.2009.05.004
  25. Mayhew PD, Brown DC. Prospective evaluation of two intracorporeally-sutured laparoscopic gastropexy techniques compared to laparoscopic-assisted gastropexy in dogs. In: Proceedings of the 2008 ACVS Veterinary Symposium. San Diego; 2008: p22.
  26. Mayhew PD, Mehler SJ, Radhakrishnan A. Laparoscopic cholecystectomy of uncomplicated gall bladder mucocele in six dogs. Vet surg 2008; 37: 625-630. https://doi.org/10.1111/j.1532-950X.2008.00428.x
  27. McGee MF, Schomisch SJ, Marks JM, Delaney CP, Jin J, Williams C, Chak A, Matteson DT, Andrews J, Ponsky JL. Late phase TNF-alpha depression in natural orifice translumenal endoscopic surgery (NOTES) peritoneoscopy. Surgery 2008; 143: 318-328. https://doi.org/10.1016/j.surg.2007.09.032
  28. Morino M, Giraudo G, Festa V. Alterations in hepatic function during laparoscopic surgery. An experimental clinical study. Surg Endosc 1998; 12: 968-972. https://doi.org/10.1007/s004649900758
  29. Neudecker J, Sauerland S, Neugebauer E, Bergamaschi R, Bonjer HJ, Cuschieri A, Fuchs KH, Jacobi CH, Jansen FW, Koivusalo AM, Lacy A, McMahon MJ, Millat B, Schwenk W. The European Association for Endoscopic Surgery clinical practice guideline on the pneumoperitoneum for laparoscopic surgery. Surg Endosc 2002; 16: 1121-1143. https://doi.org/10.1007/s00464-001-9166-7
  30. Pelaez MJ, Bouvy BM, Dupre GP. Laparoscopic adrenalectomy for treatment of unilateral adrenocortical carcinomas: techniques, complications and results in seven dogs. Vet Surg 2008; 37: 444-453. https://doi.org/10.1111/j.1532-950X.2008.00410.x
  31. Pelosi MA. Laparoscopic appendectomy using a single umbilical puncture (minilaparoscopy). J Reprod Med 1992; 37: 588-594.
  32. Pike FS, Berg J, King NW, Penninck DG, Webster CR. Gall bladder mucocele in dogs: 30 cases (2000-2002). J Am Vet Med Assoc 2004; 224: 1615-1622. https://doi.org/10.2460/javma.2004.224.1615
  33. Poon CM, Chan KW, Lee DW, Chan KC, Ko CW, Cheung HY. Two-port versus four-port laparoscopic cholecystectomy. Surg Endosc 2003; 17: 1624-1627. https://doi.org/10.1007/s00464-002-8718-9
  34. Reddy N, Rao P. Per oral transgastric endoscopic appendectomy in human. Abstract presented at 45th Annual Conference of the Society of Gastrointestinal Endoscopy of India; February 28-29, 2004; Jaipur, India.
  35. Saber AA, Laraja RD, Nalbandian HI, Pablos-Mendez A, Hanna K, Changes in liver function tests after laparoscopic cholecystectomy: not so rare, not always ominous. Am Surg 2000; 66: 699-702.
  36. Sakorafas G, Anagnostopoulos G, Stafyla V. Elevation of serum liver enzyme after laparoscopic cholecystectomy. N Z Med J 2005; 118: U1317.
  37. Tan M, Xu FF, Peng JS, Li DM, Chen LH, Lv BJ, Zhao ZX, Huang C, Zheng CX. Changes in the level of serum liver enzymes after laparoscopic surgery. World J Gastroenterol 2003; 9: 364-367. https://doi.org/10.3748/wjg.v9.i2.364
  38. Trichak S. 3 port v/s 4 port cholecystectomy. Surg endosc 2003; 17: 1434-1436. https://doi.org/10.1007/s00464-002-8713-1
  39. Walsh PJ, Remedios AM, Ferguson JF, Walker DD, Cantwell S, Duke T. Thoracoscopic versus open partial pericardectomy in dogs: comparison of post-operative pain and morbidity. Vet Surg 1999; 28: 472-479. https://doi.org/10.1111/j.1532-950X.1999.00472.x
  40. Walter R, Dunn ME, d' Anjou MA, Lecuyer M. Nonsurgical resolution of gallbladder mucocele in two dogs. J Am Vet Med Assoc 2008; 232: 1688-1693. https://doi.org/10.2460/javma.232.11.1688
  41. Worley DR, Hottinger HA, Lawrence HJ. Surgical management of gallbladder mucoceles in dogs: 22cases (1999-2003). J Am Vet Med Assoc 2004; 225: 1418-1422. https://doi.org/10.2460/javma.2004.225.1418