Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Candida tropicalis arthritis of the elbow in a patient with Ewing's sarcoma that successfully responded to itraconazole

  • Kim, Seung-Youn (Department of Pediatrics, Korean Cancer Center Hospital) ;
  • Lim, Jung-Sub (Department of Pediatrics, Korean Cancer Center Hospital) ;
  • Kim, Dong-Hwan (Department of Pediatrics, Korean Cancer Center Hospital) ;
  • Lee, Hyeon-Jeong (Department of Pediatrics, Korean Cancer Center Hospital) ;
  • Cho, Joong-Bum (Department of Pediatrics, Korean Cancer Center Hospital) ;
  • Lee, Jun-Ah (Department of Pediatrics, Korean Cancer Center Hospital) ;
  • Kim, Dong-Ho (Department of Pediatrics, Korean Cancer Center Hospital)
  • Received : 2011.03.25
  • Accepted : 2011.06.13
  • Published : 2011.09.15
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Abstract

Fungal infections are rarely responsible for arthritis. Few cases of fungal arthritis have been reported, even in immunocompromised hosts susceptible to low-virulence organisms. Herein, the authors report the first case of Candida tropicalis arthritis in a child with a solid tumor. A 13-year-old boy with Ewing's sarcoma developed arthritis in his elbow during the neutropenic period after chemotherapy. Despite treatment with broad-spectrum antibiotics, his condition did not improve and serial blood cultures failed to reveal any causative organisms. After surgical drainage, culture of the joint fluid revealed the presence of C. tropicalis. Itraconazole treatment was started and after 3 months of therapy, the patient completely recovered full elbow function.

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References

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Cited by

  1. Clinical Pharmacology of Itraconazole in Children and Adolescents vol.9, pp.2, 2011, https://doi.org/10.1007/s12281-015-0218-1
  2. Candida Arthritis: Analysis of 112 Pediatric and Adult Cases vol.3, pp.1, 2016, https://doi.org/10.1093/ofid/ofv207
  3. Breakthrough invasive candidiasis in pediatric patient with Ewing’s sarcoma: dinical case report and literature review vol.14, pp.4, 2019, https://doi.org/10.17650/1818-8346-2019-14-4-59-66