Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Nootropic and Anti-amnestic Effect of PPA on scopolamine-induced Cognitive Impairment in Mice

기억력 감퇴 모델에서 영신초(靈神草), 원지(遠志), 석창포(石菖蒲) 혼합제제의 기억력 및 인지 기능 개선에 관한 연구

  • Kim, Soo-Hyun (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Chung, Dae-Kyoo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University)
  • 김수현 (대구한의대학교 한의과대학 신경정신과학교실) ;
  • 정대규 (대구한의대학교 한의과대학 신경정신과학교실)
  • Received : 2011.08.06
  • Accepted : 2011.10.31
  • Published : 2011.12.30
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Abstract

In the present study, we assessed the effect of the PPA (Polygala japonica Houtt., Polygala tenuifolia WILLD. and Acorus gramineus SOLAND. mixed preparation), a traditional herbal prescription, on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of PPA was investigated using a passive avoidance test, Y-maze test and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). A single PPA (400 and 800 (mg/kg)) administration significantly reversed the scopolamine-induced cognitive impairments in the passive avoidance test (P<0.05). On the Y-maze test, PPA (400 and 800 (mg/kg)) also significantly reversed scopolamine-induced cognitive impairments in mice (P<0.05). PPA also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<0.05). These results suggest that PPA attenuates amnesic state induced by scopolamine and that these Effect are mediated by enhancing the cholinergic dysfunction.

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