Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Radiation-Induced Glioblastoma Multiforme in a Remitted Acute Lymphocytic Leukemia Patient

  • Joh, Dae-Won (Department of Neurosurgery, Kyung Hee University Hospital, Kyung Hee University School of Medicine) ;
  • Park, Bong-Jin (Department of Neurosurgery, Kyung Hee University Hospital, Kyung Hee University School of Medicine) ;
  • Lim, Young-Jin (Department of Neurosurgery, Kyung Hee University Hospital, Kyung Hee University School of Medicine)
  • Received : 2011.01.28
  • Accepted : 2011.08.30
  • Published : 2011.09.28
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Abstract

Radiation therapy has been widely applied for cancer treatment. Childhood acute lymphocytic leukemia (ALL), characterized by frequent central nervous system involvement, is a well documented disease for the effect of prophylactic cranio-spinal irradiation. Irradiation, however, acts as an oncogenic factor as a delayed effect and it is rare that glioblastoma multiforme develops during the remission period of ALL. We experienced a pediatric radiation-induced GBM patient which developed during the remission period of ALL, who were primarily treated with chemotherapeutic agents and brain radiation therapy for the prevention of central nervous system (CNS) relapse. Additionally, we reviewed the related literature regarding on the effects of brain irradiation in childhood and on the prognosis of radiation induced GBM.

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References

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