Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of the Red Garlic Extract for Anti-Obesity and Hypolipidemic in Obese Rats Induced High Fat Diet

홍마늘 추출물이 고지방식이로 유도된 비만 흰쥐의 항비만 및 지질개선에 미치는 영향

  • Lee, Soo-Jung (Department of Food Science and Nutrition, Institute of Agriculture and Life Sciences, Gyeongsang National University) ;
  • Kim, Ra-Jeong (Department of Food Science and Nutrition, Institute of Agriculture and Life Sciences, Gyeongsang National University) ;
  • Ryu, Ji-Hyun (Department of Food Science and Nutrition, Institute of Agriculture and Life Sciences, Gyeongsang National University) ;
  • Shin, Jung-Hye (Namhae Garlic Research Institute) ;
  • Kang, Min-Jung (Namhae Garlic Research Institute) ;
  • Kim, In-Soo (Department of Food Science and Nutrition, Institute of Agriculture and Life Sciences, Gyeongsang National University) ;
  • Sung, Nak-Ju (Department of Food Science and Nutrition, Institute of Agriculture and Life Sciences, Gyeongsang National University)
  • 이수정 (경상대학교 식품영양학과.농업생명과학연구원) ;
  • 김라정 (경상대학교 식품영양학과.농업생명과학연구원) ;
  • 류지현 (경상대학교 식품영양학과.농업생명과학연구원) ;
  • 신정혜 ((재)남해마늘연구소) ;
  • 강민정 ((재)남해마늘연구소) ;
  • 김인수 (경상대학교 식품영양학과.농업생명과학연구원) ;
  • 성낙주 (경상대학교 식품영양학과.농업생명과학연구원)
  • Received : 2010.12.22
  • Accepted : 2011.02.09
  • Published : 2011.02.28
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Abstract

This study tested the anti-obesity and hypolipidemic effects of red garlic extract in obese rats induced by a high fat diet over a period of 4 weeks. Red garlic extract of 15 brix was added in 1, 3, 5 and 7% ratios in diets. The obesity index and body fat content significantly decreased in rats fed a diet with over 3% red garlic extract compared to the control group. There was no significant difference in weight of visceral and epididymal fat in rats fed red garlic extract. Total lipid and triglyceride levels in serum were significantly decreased in a dose-dependent manner, and AI and CRF also fell. ALT and AST activities in groups fed red garlic extract were decreased compared to the control group. Total lipid level in liver tissue of the groups fed 5-7% red garlic extract exhibited a significant decrease compared to the control group. Total cholesterol and triglyceride levels in feces were significantly increased in rats fed a diet with over 5% red garlic extract. Lipid peroxide levels were significantly decreased in the groups fed diets with 5-7% red garlic and antioxidant activity in serum was significantly increased in the group fed a diet with 7% red garlic extract compared to the control group. Our results suggest that red garlic extract could have anti-obesity and hypolipidemic effects for suppressing obesity index and decreasing lipid profiles.

고지방식이로 유도된 비만흰쥐에 15 brix의 홍마늘 열수추출물을 1%, 3%, 5% 및 7%로 식이 중에 혼합급이하여 체내 지질 함량 및 항비만 효과를 측정하였다. 비만지수와 체지방량은 3% 이상의 홍마늘 추출물의 급이시대조군에 비해 유의적으로 감소되었으나, 내장 지방 및 부고환 주변 지방 함량은 홍마늘 추출물의 급이에 따른 유의차가 없었다. 혈청 중의 총 지질 및 중성지방은 추출물의 첨가량이 증가됨에 따라 유의적으로 감소하였으며, 동맥경화지수와 심혈관질환 위험지수도 감소되었다. ALT 및 AST 활성은 홍마늘 추출물 급이시 대조군에 비해감소되었다. 간 조직 중 총 지질 함량은 5-7%의 홍마늘 추출물 급이군에서 유의적으로 감소되었으며, 홍마늘 추출물의 5% 이상 급이시 분변 중에 총 콜레스테롤 및 중성지방의 배설이 증가되었다. 혈청 중 지질 과산화물 함량은 5-7%의 홍마늘 추출물 급이군에서 유의적으로 감소되었으며, 항산화 활성은 7% 급이군에서 유의적으로 상승되었다. 따라서 홍마늘 추출물은 분변으로 콜레스테롤 및 중성지방의 배출을 증가시킴으로써 체내 지질 저하 및 항비만 효과를 내는 것으로 사료된다.

Keywords

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