Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Fatty Acid Components of Hardy Kiwifruit (Actinidia arguta) as IL-4 Production Inhibitor

  • Park, Hye-Min (Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Son, Mi-Won (Research Laboratory, Dong-A Pharmaceutical Company, Ltd.) ;
  • Kim, Dong-Hyun (Institute of Molecular Biology and Genetics) ;
  • Kim, Seon-Hee (Helixir, Co., Ltd. Biotechnology Incubating Center, Seoul National University) ;
  • Kim, Sung-Hoon (College of Oriental Medicine, Cancer Preventive Material Development Research Center, Kyung Hee University) ;
  • Kwon, Hak-Cheol (Korea Institute of Science and Technology, Gangneung Institute) ;
  • Kim, Sun-Yeou (Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University)
  • Received : 2010.08.16
  • Accepted : 2010.12.16
  • Published : 2011.01.31
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Abstract

The fruit of Actinidia arguta (AA) has been used mainly for the treatment of skin diseases, diuresis, diabetes mellitus and osteoporosis in Korean traditional medicine. It is known that AA (hardy kiwi) fruit extract has an effect on 2-chloro-1,3,5-trinitrobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Mode of action for it is associated with the modulation of biphasic Th1/Th2 cytokines. Furthermore, DA9102 containing AA is a herbal medicine currently under phase II clinical trial for atopic dermatitis in Korea. However, no active principles of AA on the decrease of Th2 cytokines including IL-4 and IL-10 have been identified. In this study, bioactivity-guided fractionation of an alcohol extract from the dried fruits of AA using ELISA assay for IL-4 production led to the isolation of $\alpha$-linolenic acid (I), linoleic acid (II), ethyl linolenate (III), ethyl linoleate (IV) and ethyl stearate (V) as the major active components. These compounds showed the down-regulatory effects of IL-4 production in A23187-stimulated RBL-2H3 cells without cytotoxicity.

Keywords

References

  1. Abbas, A. K., Murphy, K. M. and Sher, A. (1991) Functional diversity ofhelper T lymphocytes. Nature 383, 787-793.
  2. Bomford. R. (1981) The adjuvant activity of fatty acid esters. The roleof acyl chain length and degree of saturation. Immunology 44, 187-192.
  3. Byberg, K., Oymar, K. and Aksnes, L. (2007) Fatty acids in cord bloodplasma, the relation to soluble CD23 and subsequent atopy. ProstaglandinsLeukot. Essent. Fatty. Acids. 28, 1-5.
  4. Calder, P. C. (2003) n-3 Polyunsaturated fatty acids and inflammation:From molecular biology to the clinic. Lipids 38, 343-352. https://doi.org/10.1007/s11745-003-1068-y
  5. Calder, P. C. (2006) Abnormal fatty acid profiles occur in atopic dermatitisbut what do they mean? Clini. Exp. Allergy. 36, 138-141. https://doi.org/10.1111/j.1365-2222.2006.02433.x
  6. Choi, J. J., Park, B. K., Song, G. Y., Kim, J. S., Kim, J. H., Kim, D. H.and Jin, M. (2007) Establishment of an in vitro test system to evaluatethe down-regulatory activities of natural products on IL-4. Arch.Pharm. Res. 30, 1102-1110. https://doi.org/10.1007/BF02980244
  7. Christie, W. W. (2003) Lipid analysis: isolation, separation, identification,and structural analysis of lipids. The Oily Press, Bridgwater(UK).
  8. Coca, A. F. and Cooke, R. A. (1923) On the classification of the phenomenaof hypersensitiveness. J. Immunol. 6, 63.
  9. Coffman, R. L. and Carty, J. (1986) A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma. J. Immunol.136, 949-954.
  10. Daikonya, A., Katsuki, S., Wu, J. B. and Kitanaka, S. (2002) Anti-allergicagents from natural sources (4): anti-allergic activity of newphloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae).Chem. Pharm. Bull. 50, 1566-1569. https://doi.org/10.1248/cpb.50.1566
  11. Falkenstein, E., Groth, B., Mithofer, A. and Weiler, E. W. (1991) Methyljasmonateand ${\alpha}-linolenic$ acid are potent inducers of tendril coiling. Planta. 185, 316-322
  12. Fujiwaki, T. and Furusho, K. (1992) The effects of rice bran broth bathingin patients with atopic dermatitis. Acta. Paediatr. Jpn. 34, 505-510. https://doi.org/10.1111/j.1442-200X.1992.tb00997.x
  13. Gimenez-Arnau, A., Barranco, C., Alberola, M., Wale, C., Serrano, S.,Buchanan, M. R. and Camarasa, J. G. (1997) Effects of linoleicacid supplements on atopic dermatitis. Adv. Exp. Med. Biol. 433,285-289. https://doi.org/10.1007/978-1-4899-1810-9_60
  14. Kawamoto, S., Kita, M., Hamada, M., Aki, T., Shigeta, S., Suzuki, O.and Ono, K. (2001) Lack of effect of the abnormal fatty acid metabolismin NC/Nga mice on their atopic dermatitis. Biosci. Biotechnol.Biochem. 65, 431-434. https://doi.org/10.1271/bbb.65.431
  15. Kimata, M., Inagaki, N. and Nagai, H. (2000) Effects of luteolin andother flavonoids on IgE-mediated allergic reactions. Planta. Med.66, 25-29. https://doi.org/10.1055/s-2000-11107
  16. Kim, D., Kim, S. H., Park, E. J., Kim, J., Cho, S. H., Kagawa, J., Arai,N., Jun, K., Kiyono, H. and Kim, S. (2009) Suppression of allergicdiarrhea in murine ovalbumin-induced allergic diarrhea model byPG102, a water-soluble extract prepared from Antinidia acguta. Int.Arch. Allergy Immunol. 150, 164-171. https://doi.org/10.1159/000218119
  17. Kim, J. S., Choi, Y. H., Seo, J. H., Lee, J. W., Kim, Y. S., Ryu, S. Y.,Kang, J. S., Kim, Y. K. and Kim, S. H. (2004) Chemical Constituentsfrom the Root of Brassica campestris ssp rapa. Korean J. Parmacogn.35, 259-263.
  18. Laitinen, K., Sallinen, J., Linderborg, K. and Isolauri, E. (2006) Serum,cheek cell and breast milk fatty acid compositions in infants withatopic and non-atopic eczema. Clin. Exp. Allergy 36, 166-173. https://doi.org/10.1111/j.1365-2222.2006.02417.x
  19. Lee, H. S., Kim, S. K., Han, J. B., Choi, H. M., Park, J. H., Kim, E. C.,Choi, M. S., An, H. J., Um, J. Y., Kim, H. M. and Min, B. I. (2006)Inhibitory effects of Rumex japonicus Houtt. on the development ofatopic dermatitis-like skin lesions in NC/Nga mice. Br. J. Dermatol.155, 33-38. https://doi.org/10.1111/j.1365-2133.2006.07303.x
  20. Marcel, S. F., Jie, M. S. and Mustafa, J. (1997) High-resolution nuclearmagnetic resonance spectroscopy--applications to fatty acids andtriacylglycerols. Lipids 32, 1019-1034. https://doi.org/10.1007/s11745-997-0132-y
  21. Matich, A. J., Young, H., Allen, J. M., Wang, M. Y., Fielder, S., Mc-Neilage, M. A. and MacRae, E. A. (2003) Actinidia arguta: volatilecompounds in fruit and flowers. Phytochemistry 63, 285-301. https://doi.org/10.1016/S0031-9422(03)00142-0
  22. Moto, M., Okamura, M., Watanabe, T., Kashida, Y. and Mitsumori, K.(2004) Thirteen-week repeated dose toxicity of rice bran glycosphingolipidin Wistar Hannover (GALAS) rats. J. Toxicol. Sci. 29,73-80. https://doi.org/10.2131/jts.29.73
  23. Park, E. J., Kim, B., Eo, H., Park, K., Kim, Y., Lee, H. J., Son, M.,Chang, Y. S., Cho, S. H., Kim, S. and Jin, M. (2005) Control of IgEand selective T(H)1 and T(H)2 cytokines by PG102 isolated fromActinidia arguta. J. Allergy Clin. Immunol. 116, 1151-1157. https://doi.org/10.1016/j.jaci.2005.07.024
  24. Peroni, D. G., Piacentini, G. L., Bodini, A., Rigotti, E., Pigozzi, R. andBoner, A. L. (2007) Prevalence and risk factors for atopic dermatitisin preschool children. Br. J. Dermatol. 7, 1-5.
  25. Pouchert, C. and Behnke, J. (1993) Aldrich Library of 13C and 1H FT-NMR Spectra.
  26. Ren, J., Han, E. J. and Chung, S. H. (2007) In vivo and in vitro anti-inflammatory activities of alpha-linolenic acid isolated from Actinidiapolygama fruits. Arch. Pharm. Res. 30, 708-714. https://doi.org/10.1007/BF02977632
  27. Ring, J., Kramer, U., Schafer, T. and Behrendt, H. (2001) Why are allergiesincreasing? Curr. Opin. Immunol. 13, 701-708. https://doi.org/10.1016/S0952-7915(01)00282-5
  28. Rivera, D. G., Balmaseda, I. H., Leon, A. A., Hernandez, B. C., Montiel,L. M., Garrido, G. G., Cuzzocrea, S. and Hernandez, R. D. (2006)Anti-allergic properties of Mangifera indica L. extract (Vimang) andcontribution of its glucosylxanthone mangiferin. J. Pharm. Pharmacol.58, 385-392. https://doi.org/10.1211/jpp.58.3.0014
  29. Rodeiro, I., Cancino, L., Gonzalez, J. E., Morffi, J., Garrido, G.,Gonzalez, R. M., Nunez, A. and Delgado, R. (2006) Evaluation ofthe genotoxic potential of Mangifera indica L. extract (Vimang), a new natural product with antioxidant activity. Food Chem. Toxicol.44, 1707-1713. https://doi.org/10.1016/j.fct.2006.05.009
  30. Shin, H. Y., Na, H. J., Moon, P. D., Shin, T., Shin, T. Y., Kim, S. H.,Hong, S. H. and Kim, H. M. (2004) Inhibition of mast cell-dependentimmediate-type hypersensitivity reactions by purple bamboosalt. J. Ethnopharmacol. 91, 153-157. https://doi.org/10.1016/j.jep.2003.12.006
  31. Shin, Y. W., Bae, E. A., Cai, X. F., Lee, J. J. and Kim, D. H. (2007) In vitroand in vivo antiallergic effect of the fructus of Evodia rutaecarpaand its constituents. Biol. Pharm. Bull. 30, 197-199. https://doi.org/10.1248/bpb.30.197
  32. Thakur, S. C., Thakur, S. S., Chaube, S. K. and Singh, S. P. (2005) An etheral extract of Kamala (Mallotus philippinensis (Moll.Arg) Lam.)seed induce adverse effects on reproductive parameters of femalerats. Reprod. Toxicol. 20, 149-156. https://doi.org/10.1016/j.reprotox.2004.12.008
  33. Vercelli, D. (2001) Immunoglobulin E and its regulators. Curr Opin AllergyClin Immunol. 1, 61-65. https://doi.org/10.1097/00130832-200102000-00011
  34. Yang, X. W., Zhang, H., Li, M., Du, L. J., Yang, Z. and Xiao, S. Y. (2006)Studies on the alkaloid constituents of Evodia rutaecarpa (Juss)Benth var. bodinaieri (Dode) Huang and their acute toxicity in mice.J. Asian. Nat. Prod. Res. 8, 697-703. https://doi.org/10.1080/10286020412331286425

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