Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Polyacetylene Compound from Cirsium japonicum var. ussuriense Inhibits the LPS-Induced Inflammatory Reaction via Suppression of NF-κB Activity in RAW 264.7 Cells

  • Kang, Tae-Jin (Institute of Chronic Disease, Sahmyook University) ;
  • Moon, Jung-Sun (Traditional Medicines Research Institute, Sahmyook University) ;
  • Lee, Sook-Yeon (Traditional Medicines Research Institute, Sahmyook University) ;
  • Yim, Dongs-Sool (Traditional Medicines Research Institute, Sahmyook University)
  • Received : 2010.08.16
  • Accepted : 2010.10.18
  • Published : 2011.01.31
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Abstract

Cirsium japonicum var. ussuriense is known to have a variety of biological activities, including anti-inflammatory, analgesic activity and antipyretic activity. In this study we investigated the role of polyacetylene compound, 1-Heptadecene-11, 13-diyne-8, 9, 10-triol (PA) from the root of Cirsium japonicum var. ussuriense as an immune-modulator. PA was evaluated as inhibitors of some macrophage functions involved in the inflammatory process. We tested the effect of PA on the production of pro-inflammatory cytokines, interleukin-1beta (IL-$1{\beta}$) and tumor necrosis factor-alpha (TNF-$\alpha$), and nitric oxide (NO) in murine macrophage cell line, RAW264.7. There was no effect on cytokine production of macrophages by PA itself. However, PA inhibited lipopolysaccharide (LPS)-induced IL-$1{\beta}$ and TNF-$\alpha$ production by macrophages at a dose dependent manner. PA also suppressed the NO production of macrophages by LPS. LPS-induced NF-${\kappa}B$ activity was decreased by treatment of PA. Therefore, these results suggest that PA has anti-inflammatory effect by inhibiting the NF-${\kappa}B$ activation.

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References

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