DOI QR코드

DOI QR Code

High Shear Stress at the Surface of Enhancing Plaque in the Systolic Phase is Related to the Symptom Presentation of Severe M1 Stenosis

  • Suh, Dae-Chul (Department of Radiology and the Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Park, Sung-Tae (Department of Radiology, Soonchunhyang University Hospital) ;
  • Oh, Tack-Sun (Department of Radiology and the Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Park, Sang-Ok (Department of Radiology and the Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Lim, Ok-Kyun (Department of Radiology and the Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Park, Soon-Chan (Department of Radiology and the Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Ryu, Chang-Woo (Department of Radiology, East-West Neomedical Center, Kyunghee University, College of Medicine) ;
  • Lee, Deok-Hee (Department of Radiology and the Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Ko, Young-Bae (Department of Mechanical Engineering, Dankook University) ;
  • Lee, Sang-Wook (School of Mechanical and Automotive Engineering, University of Ulsan) ;
  • Yoon, Kyung-Hwan (Department of Mechanical Engineering, Dankook University) ;
  • Kim, Jong-Sung (Department of Neurology, University of Ulsan, College of Medicine, Asan Medical Center)
  • Published : 2011.08.01

Abstract

The computational fluid dynamics methods for the limited flow rate and the small dimensions of an intracranial artery stenosis may help demonstrate the stroke mechanism in intracranial atherosclerosis. We have modeled the high wall shear stress (WSS) in a severe M1 stenosis. The high WSS in the systolic phase of the cardiac cycle was well-correlated with a thick fibrous cap atheroma with enhancement, as was determined using high-resolution plaque imaging techniques in a severe stenosis of the middle cerebral artery.

Keywords

References

  1. Suh DC, Lee SH, Kim KR, Park ST, Lim SM, Kim SJ, et al. Pattern of atherosclerotic carotid stenosis in Korean patients with stroke: different involvement of intracranial versus extracranial vessels. AJNR Am J Neuroradiol 2003;24:239-244
  2. Suh DC, Kim JK, Choi JW, Choi BS, Pyun HW, Choi YJ, et al. Intracranial stenting of severe symptomatic intracranial stenosis: results of 100 consecutive patients. AJNR Am J Neuroradiol 2008;29:781-785 https://doi.org/10.3174/ajnr.A0922
  3. Groen HC, Gijsen FJ, van der Lugt A, Ferguson MS, Hatsukami TS, van der Steen AF, et al. Plaque rupture in the carotid artery is localized at the high shear stress region: a case report. Stroke 2007;38:2379-2381 https://doi.org/10.1161/STROKEAHA.107.484766
  4. Groen HC, Gijsen FJ, van der Lugt A, Ferguson MS, Hatsukami TS, Yuan C, et al. High shear stress influences plaque vulnerability Part of the data presented in this paper were published in Stroke 2007;38:2379-81. Neth Heart J 2008;16:280-283 https://doi.org/10.1007/BF03086163
  5. Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA 1999;282:2035-2042 https://doi.org/10.1001/jama.282.21.2035
  6. Suh DC, Sung KB, Cho YS, Choi CG, Lee HK, Lee JH, et al. Transluminal angioplasty for middle cerebral artery stenosis in patients with acute ischemic stroke. AJNR Am J Neuroradiol 1999;20:553-558
  7. Choi JW, Kim JK, Choi BS, Kim JH, Hwang HJ, Kim JS, et al. Adjuvant revascularization of intracranial artery occlusion with angioplasty and/or stenting. Neuroradiology 2009;51:33-43 https://doi.org/10.1007/s00234-008-0462-y
  8. Choi JW, Kim JK, Choi BS, Lim HK, Kim SJ, Kim JS, et al. Angiographic pattern of symptomatic severe M1 stenosis: comparison with presenting symptoms, infarct patterns, perfusion status, and outcome after recanalization. Cerebrovasc Dis 2010;29:297-303 https://doi.org/10.1159/000275508
  9. Antiga L, Piccinelli M, Botti L, Ene-Iordache B, Remuzzi A, Steinman DA. An image-based modeling framework for patient-specific computational hemodynamics. Med Biol Eng Comput 2008;46:1097-1112 https://doi.org/10.1007/s11517-008-0420-1
  10. Oh TS, Ko YB, Park ST, Yoon K, Lee SW, Park JW, et al. Computational flow dynamics study in severe carotid bulb stenosis with ulceration. Neurointervention 2010;5:97-102 https://doi.org/10.5469/neuroint.2010.5.2.97
  11. Babikian VL, Caplan LR. Brain embolism is a dynamic process with variable characteristics. Neurology 2000;54:797-801 https://doi.org/10.1212/WNL.54.4.797
  12. Ryu CW, Jahng GH, Kim EJ, Choi WS, Yang DM. High resolution wall and lumen MRI of the middle cerebral arteries at 3 tesla. Cerebrovasc Dis 2009;27:433-442 https://doi.org/10.1159/000209238
  13. Niizuma K, Shimizu H, Takada S, Tominaga T. Middle cerebral artery plaque imaging using 3-Tesla high-resolution MRI. J Clin Neurosci 2008;15:1137-1141 https://doi.org/10.1016/j.jocn.2007.09.024

Cited by

  1. Intracranial Stenting of Subacute Symptomatic Atherosclerotic Occlusion Versus Stenosis vol.42, pp.12, 2011, https://doi.org/10.1161/strokeaha.111.622282
  2. Outpatient (Same-day care) Neuroangiography and Neurointervention vol.7, pp.1, 2011, https://doi.org/10.5469/neuroint.2012.7.1.17
  3. Computer Simulations in Stroke Prevention: Design Tools and Virtual Strategies Towards Procedure Planning vol.4, pp.4, 2013, https://doi.org/10.1007/s13239-013-0134-x
  4. Intracranial Stenting for Severe Symptomatic Stenosis: Self-Expandable versus Balloon-Expandable Stents vol.19, pp.3, 2013, https://doi.org/10.1177/159101991301900303
  5. Computational Modeling with Fluid-Structure Interaction of the Severe M1 Stenosis Before and After Stenting vol.8, pp.1, 2011, https://doi.org/10.5469/neuroint.2013.8.1.23
  6. Computational Fluid Dynamics of Intracranial Artery Using 3-Dimensional Angiography: Potentials and Technical Considerations vol.69, pp.1, 2011, https://doi.org/10.3348/jksr.2013.69.1.5
  7. Computational Fluid Dynamics of Intracranial and Extracranal Arteries using 3-Dimensional Angiography: Technical Considerations with Physician's Point of View vol.8, pp.2, 2011, https://doi.org/10.5469/neuroint.2013.8.2.92
  8. Considerations of Blood Properties, Outlet Boundary Conditions and Energy Loss Approaches in Computational Fluid Dynamics Modeling vol.9, pp.1, 2011, https://doi.org/10.5469/neuroint.2014.9.1.1
  9. Emerging Techniques for Evaluation of the Hemodynamics of Intracranial Vascular Pathology vol.28, pp.1, 2011, https://doi.org/10.15274/nrj-2014-10115
  10. High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis vol.3, pp.4, 2011, https://doi.org/10.1093/rb/rbw021
  11. Association between basilar artery configuration and Vessel Wall features: a prospective high-resolution magnetic resonance imaging study vol.19, pp.1, 2011, https://doi.org/10.1186/s12880-019-0388-3
  12. Multiscale modeling of blood flow to assess neurological complications in patients supported by venoarterial extracorporeal membrane oxygenation vol.129, pp.None, 2011, https://doi.org/10.1016/j.compbiomed.2020.104155