A Case of Graves' Disease Following Subacute Thyroiditis

아급성 갑상선염 후 발병된 그레이브스병 1예

  • Cheong, Hyeong-Cheol (Department of Internal Medicine, Wonkwang University College of Medicine) ;
  • Noh, Hye-Jung (Department of Internal Medicine, Wonkwang University College of Medicine) ;
  • Park, Byoung-Hyun (Department of Internal Medicine, Wonkwang University College of Medicine) ;
  • Cho, Chung-Gu (Department of Internal Medicine, Wonkwang University College of Medicine)
  • 정형철 (원광대학교 의과대학 내과학교실) ;
  • 노혜정 (원광대학교 의과대학 내과학교실) ;
  • 박병현 (원광대학교 의과대학 내과학교실) ;
  • 조정구 (원광대학교 의과대학 내과학교실)
  • Published : 2011.05.01

Abstract

Subacute thyroiditis is a spontaneously resolving inflammatory disease of the thyroid gland, which is usually associated with aviral infection and genetic factors. In some cases of this disorder, thyroid autoantibodies can appear, probably due to the inflammatoryrelease of thyroid antigens, althoughtheir pathophysiological role in the course of this disease is not yet fullyunderstood. The occurrence of Graves' disease after subacute thyroiditis is extremely rare, and only a few cases have been reported.Here, we report a case of a middle-aged woman who developed Graves' disease after subacute thyroiditis.

저자들은 아급성 갑상선염을 진단 받고 보존적 치료를 시행 후 호전된 환자에서 2년 후 그레이브스병이 발병한 1예를 경험하여 아급성 갑상선염 환자에서 자가면역항체가 양성을 보일 경우 추후 그레이브스병의 발생에 대한 지속적인 추적 관찰이 필요할 수 있음을 강조하면서 보고하는 바이다.

Keywords

References

  1. Jeon JS, Kim WB, Park HY, et al. The incidence of thyroid autoantibody in subacute thyroiditis and the clinical characteristics of creeping thyroiditis. J Korean Soc Endocrinol 1996;11: 438-444.
  2. Bartalena L, Bogazzi F, Pecori F, et al. Graves' disease occurring after subacute thyroiditis: report of a case and review of the literature. Thyroid 1996;6:345-348. https://doi.org/10.1089/thy.1996.6.345
  3. Fukata S, Matsuzuka F, Kobayashi A, et al. Development of Graves' disease after subacute thyroiditis: two unusual cases. Acta Endocrinol (Copenh) 1992;126:495-496.
  4. Yoon HJ, Hwang YH, Lee KY, et al. Recurrence of subacute thyroiditis: report of two cases. J Korean Soc Endocrinol 2002; 17:124-129.
  5. Volpe R, Row VV, Ezrin C. Circulating viral and thyroid antibodies in subacute thyroiditis. J Clin Endocrinol Metab 1967; 27:1275-1284. https://doi.org/10.1210/jcem-27-9-1275
  6. Wall JR, Fang SL, Ingbar SH, et al. Lymphocyte transformation in response to human thyroid extract in patients with subacute thyroiditis. J Clin Endocrinol Metab 1979;43:587-590.
  7. Litaka M, Momotani N, Hisaoka T, et al. TSH receptor antibody-associated thyroid dysfunction following subacute thyroiditis. Clin Endoclinol (Oxf) 1998;48:445-453. https://doi.org/10.1046/j.1365-2265.1998.00416.x
  8. Smyth PP, Neylan D, McMullan NM, et al. Sequential presentation of a case of hyperthyroidism with autonomously functioning nodules and Graves' disease in the presence of IgG thyroid stimulators. Acta Endocrinol (Copenh) 1988;118:474-478.
  9. Chiovato L, Santini F, Vitti P, et al. A. Appearance of thyroid stimulating antibody and Graves' disease after radioiodine therapy for toxic nodular goitre. Clin Endocrinol (Oxf) 1994;40:803-806. https://doi.org/10.1111/j.1365-2265.1994.tb02516.x
  10. Walfish PG, Caplan D, Rosen IB. Postparathyroidectomy transient thyrotoxicosis. J Clin Endocrinol Metab 1992;75: 224-227. https://doi.org/10.1210/jc.75.1.224
  11. Wasnich RD, Grumet FC, Payne RO, et al. Graves' ophthalmopathy following external neck irradiation for nonthyroidal neoplastic disease. J Clin Endocrinol Metab 1973;37:703-713. https://doi.org/10.1210/jcem-37-5-703