The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Does Hyperuricemia Play a Causative Role in the Development and/or Aggravation of Renal, Cardiovascular and Metabolic Disease?

고요산혈증은 신장, 심혈관 및 대사 질환의 발생/악화 인자인가?

  • Kang, Duk-Hee (Department of Internal Medicine, Ewha Womans University School of Medicine)
  • 강덕희 (이화여자대학교 의학전문대학원 내과학교실)
  • Published : 2011.05.01
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Abstract

Although an elevation of serum uric acid level is often associated with kidney disease, cardiovascular disease and metabolicsyndrome, it remains controversial whether hyperuricemia per se is a true risk factor for the development or aggravation of thesediseases. Recent studies have demonstrated the independent role of uric acid in progression of renal disease and the development ofnew-onset hypertension and diabetes. Furthermore, lowering uric acid in these patients is found to stabilize renal function anddecrease cardiovascular morbidity, suggesting the causative role of uric acid in renal, cardiovascular and metabolic disease, ratherthan an incidental association. In this manuscript, recent understanding about the role of uric acid in the development and/oraggravation of renal, cardiovascular and metabolic diseases will be reviewed based on the results from epidemiologic, clinical andexperimental studies.

Keywords

References

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