The Korean journal of internal medicine

  • 제26권1호
  • /
  • Pages.89-93
  • /
  • 2011
  • /
  • 1226-3303(pISSN)
  • /
  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지
DOI QR코드

DOI QR Code

Epidemiology of Ciprofloxacin Resistance and Its Relationship to Extended-Spectrum ${\beta}$-Lactamase Production in Proteus mirabilis Bacteremia

  • Sohn, Kyung-Mok (Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kang, Cheol-In (Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Joo, Eun-Jeong (Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Ha, Young-Eun (Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Chung, Doo-Ryeon (Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Peck, Kyong-Ran (Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Nam-Yong (Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Song, Jae-Hoon (Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 발행 : 2011.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: We evaluated the clinical features of ciprofloxacin-resistant Proteus mirabilis bacteremia and risk factors for ciprofloxacin resistance. Methods: From October 2000 to July 2009, 37 patients with clinically significant P. mirabilis bacteremia were identified and data from patients with ciprofloxacin-resistant and ciprofloxacin-susceptible P. mirabilis bacteremia were compared. Results: The most common underlying diseases were neurologic disease (37.8%) and solid tumors (29.7%). The most common site of infection was the urinary tract (35.1%). Ten of the 37 patients (27.0%) were infected with ciprofloxacin-resistant isolates, and univariate analysis revealed a significant relationship between ciprofloxacin-resistant P. mirabilis bacteremia and neurologic disease, recent operation, L-tube insertion, percutaneous tube use, and extended-spectrum ${\beta}$-lactamase (ESBL) production (all p < 0.05). ESBL was detected in six of 10 (60%) ciprofloxacin-resistant isolates, while only three of 27 (11%) ciprofloxacin-susceptible isolates produced ESBL (p = 0.005). In a logistic regression analysis, ESBL production remained a significant factor associated with ciprofloxacin resistance, after adjusting for other variables. Conclusions: These data indicate a close association between ciprofloxacin resistance and ESBL-production in P. mirabilis bacteremia. This association is particularly troublesome because the therapeutic options for serious infections caused by ESBL-producing P. mirabilis are severely restricted.

키워드

참고문헌

  1. Endimiani A, Luzzaro F, Brigante G, et al. Proteus mirabilis bloodstream infections: risk factors and treatment outcome related to the expression of extended-spectrum beta-lactamases. Antimicrob Agents Chemother 2005;49:2598-2605. https://doi.org/10.1128/AAC.49.7.2598-2605.2005
  2. O'Hara CM, Brenner FW, Miller JM. Classification, identification, and clinical significance of Proteus, Providencia, and Morganella. Clin Microbiol Rev 2000;13:534-546. https://doi.org/10.1128/CMR.13.4.534-546.2000
  3. Wu JJ, Chen HM, Ko WC, Wu HM, Tsai SH, Yan JJ. Prevalence of extended-spectrum beta-lactamases in Proteus mirabilis in a Taiwanese university hospital, 1999 to 2005: identification of a novel CTX-M enzyme (CTX-M-66). Diagn Microbiol Infect Dis 2008;60:169-175. https://doi.org/10.1016/j.diagmicrobio.2007.08.004
  4. Uh Y, Hwang GY, Kwon O, Yoon KJ, Kim HY. Isolation frequency of extended spectrum beta-lactamase producing Escherichia coli, Klebsiella species, and Proteus mirabilis. Korean J Clin Microbiol 2007;10:119-122.
  5. Hernandez JR, Martinez-Martinez L, Pascual A, Suarez AI, Perea EJ. Trends in the susceptibilities of Proteus mirabilis isolates to quinolones. J Antimicrob Chemother 2000;45:407-408. https://doi.org/10.1093/jac/45.3.407
  6. Saito R, Okugawa S, Kumita W, et al. Clinical epidemiology of ciprofloxacin-resistant Proteus mirabilis isolated from urine samples of hospitalised patients. Clin Microbiol Infect 2007;13:1204-1206. https://doi.org/10.1111/j.1469-0691.2007.01826.x
  7. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Seventeenth Informational Supplement (Document M100-S17). Wayne (PA): Clinical and Laboratory Standards Institute, 2007.
  8. Friedman ND, Kaye KS, Stout JE, et al. Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002;137:791-797. https://doi.org/10.7326/0003-4819-137-10-200211190-00007
  9. Paterson DL, Mulazimoglu L, Casellas JM, et al. Epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum beta-lactamase production in Klebsiella pneumoniae isolates causing bacteremia. Clin Infect Dis 2000;30:473-478. https://doi.org/10.1086/313719
  10. Kang CI, Kim SH, Kim DM, et al. Risk factors for ciprofloxacin resistance in bloodstream infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae. Microb Drug Resist 2004;10:71-76. https://doi.org/10.1089/107662904323047835
  11. Lautenbach E, Strom BL, Bilker WB, Patel JB, Edelstein PH, Fishman NO. Epidemiological investigation of fluoroquinolone resistance in infections due to extended-spectrum beta-lactamase- producing Escherichia coli and Klebsiella pneumoniae. Clin Infect Dis 2001;33:1288-1294. https://doi.org/10.1086/322667
  12. Kang CI, Kim SH, Park WB, et al. Clinical epidemiology of ciprofloxacin resistance and its relationship to broad-spectrum cephalosporin resistance in bloodstream infections caused by Enterobacter species. Infect Control Hosp Epidemiol 2005;26:88-92. https://doi.org/10.1086/502492
  13. Kim JY, Park YJ, Kim SI, Kang MW, Lee SO, Lee KY. Nosocomial outbreak by Proteus mirabilis producing extended-spectrum beta-lactamase VEB-1 in a Korean university hospital. J Antimicrob Chemother 2004;54:1144-1147. https://doi.org/10.1093/jac/dkh486
  14. Eagye KJ, Kuti JL, Nicolau DP. Risk factors and outcomes associated with isolation of meropenem high-level-resistant Pseudomonas aeruginosa. Infect Control Hosp Epidemiol 2009;30:746-752. https://doi.org/10.1086/603527
  15. Tacconelli E, De Angelis G, Cataldo MA, et al. Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study. Antimicrob Agents Chemother 2009;53:4264-4269. https://doi.org/10.1128/AAC.00431-09
  16. Zavascki AP, Carvalhaes CG, Picão RC, Gales AC. Multidrugresistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy. Expert Rev Anti Infect Ther 2010;8:71-93. https://doi.org/10.1586/eri.09.108
  17. Jacoby G, Cattoir V, Hooper D, et al. qnr Gene nomenclature. Antimicrob Agents Chemother 2008;52:2297-2299. https://doi.org/10.1128/AAC.00147-08
  18. Martinez-Martinez L, Pascual A, Jacoby GA. Quinolone resistance from a transferable plasmid. Lancet 1998;351:797-799. https://doi.org/10.1016/S0140-6736(97)07322-4
  19. Kim HB, Park CH, Kim CJ, Kim EC, Jacoby GA, Hooper DC. Prevalence of plasmid-mediated quinolone resistance determinants over a 9-year period. Antimicrob Agents Chemother 2009;53:639-645. https://doi.org/10.1128/AAC.01051-08
  20. Wu JJ, Ko WC, Wu HM, Yan JJ. Prevalence of Qnr determinants among bloodstream isolates of Escherichia coli and Klebsiella pneumoniae in a Taiwanese hospital, 1999-2005. J Antimicrob Chemother 2008;61:1234-1239. https://doi.org/10.1093/jac/dkn111
  21. Wang M, Guo Q, Xu X, et al. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Antimicrob Agents Chemother 2009;53:1892-1897. https://doi.org/10.1128/AAC.01400-08
  22. Colodner R, Kometiani I, Chazan B, Raz R. Risk factors for community-acquired urinary tract infection due to quinolone-resistant E. coli. Infection 2008;36:41-45. https://doi.org/10.1007/s15010-007-7083-y
  23. Levin PD, Fowler RA, Guest C, Sibbald WJ, Kiss A, Simor AE. Risk factors associated with resistance to ciprofloxacin in clinical bacterial isolates from intensive care unit patients. Infect Control Hosp Epidemiol 2007;28:331-336. https://doi.org/10.1086/511701

피인용 문헌

  1. The Ciprofloxacin Impact on Biofilm Formation by Proteus Mirabilis and P. Vulgaris Strains vol.9, pp.4, 2011, https://doi.org/10.5812/jjm.32656
  2. Pharmacodynamics of Finafloxacin, Ciprofloxacin, and Levofloxacin in Serum and Urine against TEM- and SHV-Type Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae Isolates from Patients vol.61, pp.5, 2011, https://doi.org/10.1128/aac.02446-16
  3. Molecular Exploring of Plasmid-mediated Ampc beta Lactamase Gene in Clinical Isolates of Proteus mirabilis vol.3, pp.3, 2021, https://doi.org/10.21931/rb/2021.06.03.21