The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Prostaglandin $D_2$ and $T_H2$ Inflammation in the Pathogenesis of Bronchial Asthma

  • Arima, Masafumi (Department of Developmental Genetics (H2), Chiba University Graduate School of Medicine) ;
  • Fukuda, Takeshi (Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine)
  • Published : 2011.03.01
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Abstract

Prostaglandin D_2$ ($PGD_2$) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. $PGD_2$-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. Recently, novel functions of $PGD_2$ have been identified. To date, D prostanoid receptor (DP) and chemoattractant receptor homologous molecule expressed on $T_H2$ cells (CRTH2) have been shown to be major $PGD_2$-related receptors. These two receptors have pivotal roles mediating allergic diseases by regulating the functions of various cell types, such as $T_H2$ cells, eosinophils, basophils, mast cells, dendritic cells, and epithelial cells. This review will focus on the current understanding of the roles of $PGD_2$ and its metabolites in $T_H2$ inflammation and the pathogenesis of bronchial asthma.

Keywords

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