Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
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Acute Cerebral Infarction after FK 506 Administration in a Kidney Transplantation Recipient: A Case Report

신장 이식 환자에서 FK506 투여 후 발생한 급성 뇌 경색: 증례 보고

  • Lim, Ji-Kyung (Department of Diagnostic Radiology, College of Medicine, Yeungnam University) ;
  • Byun, Woo-Mok (Department of Diagnostic Radiology, College of Medicine, Yeungnam University) ;
  • Kim, Jae-Woon (Department of Diagnostic Radiology, College of Medicine, Yeungnam University)
  • 임지경 (영남대학교 의과대학 영상의학과) ;
  • 변우목 (영남대학교 의과대학 영상의학과) ;
  • 김재운 (영남대학교 의과대학 영상의학과)
  • Published : 2011.02.01
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Abstract

FK506 is widely used as a potent immunosuppressive agent following organ transplantation. However, the use of FK506 is associated with a wide spectrum of neurotoxicity.F K506-induced cerebral infarctions have rarely been reported. We report here on a case of the acute cerebral infarction caused by vasospasm after FK506 administration in a kidney transplantation recipient. There were areas with increased signal intensity on the diffusion-weighted image. The areas showing increased signal intensity on the diffusion- and $T_2$-weighted images demonstrated decreased signal intensity on the apparent diffusion coefficient mapping. MR angiography showed diffuse stenosis in both the anterior and middle cerebral arteries.

FK506은 장기 이식 후 널리 사용되는 강력한 면역억제제이다. FK506의 사용은 다양한 범위의 신경 독성과 관련이 있는 것으로 알려져 왔지만 FK506 투여로 인한 급성 뇌경색 발생에 대해서는 보고된 바가 거의 없다. 우리는 신장 이식 환자에서 FK506 투여로 인한 급성 뇌경색의 증례를 보고하고자 한다. 증상 발생 후 시행한 자기공명영상에서 병변은 확산강조영상과 T2 강조영상에서 고신호강도로, 겉보기확산계수 지도영상에서 저신호강도로 나타났으며 자기공명 혈관영상에서 양측 전뇌동맥과 중뇌동맥의 혈관 경축이 관찰되었다.

Keywords

References

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