Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
권호 표지
DOI QR코드

DOI QR Code

Diffusion Tensor Imaging: Exploring the Motor Networks and Clinical Applications

  • Ahn, Sung-Soo (Department of Radiology, Yonsei University College of Medicine) ;
  • Lee, Seung-Koo (Department of Radiology, Yonsei University College of Medicine)
  • Published : 2011.12.01
⟨ Previous Next ⟩

Abstract

With the advances in diffusion magnetic resonance (MR) imaging techniques, diffusion tensor imaging (DTI) has been applied to a number of neurological conditions because DTI can demonstrate microstructures of the brain that are not assessable with conventional MR imaging. Tractography based on DTI offers gross visualization of the white matter fiber architecture in the human brain in vivo. Degradation of restrictive barriers and disruption of the cytoarchitecture result in changes in the diffusion of water molecules in various pathological conditions, and these conditions can also be assessed with DTI. Yet many factors may influence the ability to apply DTI clinically, so these techniques have to be used with a cautious hand.

Keywords

References

  1. Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986;161:401-407 https://doi.org/10.1148/radiology.161.2.3763909
  2. Mori S, Oishi K, Faria AV. White matter atlases based on diffusion tensor imaging. Curr Opin Neurol 2009;22:362-369 https://doi.org/10.1097/WCO.0b013e32832d954b
  3. Berman J. Diffusion MR tractography as a tool for surgical planning. Magn Reson Imaging Clin N Am 2009;17:205-214 https://doi.org/10.1016/j.mric.2009.02.002
  4. Pizzini FB, Polonara G, Mascioli G, Beltramello A, Foroni R, Paggi A, et al. Diffusion tensor tracking of callosal fibers several years after callosotomy. Brain Res 2010;1312:10-17 https://doi.org/10.1016/j.brainres.2009.11.030
  5. Yang Q, Tress BM, Barber PA, Desmond PM, Darby DG, Gerraty RP, et al. Serial study of apparent diffusion coefficient and anisotropy in patients with acute stroke. Stroke 1999;30:2382-2390 https://doi.org/10.1161/01.STR.30.11.2382
  6. Lee SK, Kim DI, Kim J, Kim DJ, Kim HD, Kim DS, et al. Diffusion-tensor MR imaging and fiber tractography: a new method of describing aberrant fiber connections in developmental CNS anomalies. Radiographics 2005;25:53-65;discussion 66-58 https://doi.org/10.1148/rg.251045085
  7. Zhang Y, Schuff N, Jahng GH, Bayne W, Mori S, Schad L, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology 2007;68:13-19 https://doi.org/10.1212/01.wnl.0000250326.77323.01
  8. Kubicki M, Westin CF, Maier SE, Mamata H, Frumin M, Ersner-Hershfield H, et al. Diffusion tensor imaging and its application to neuropsychiatric disorders. Harv Rev Psychiatry 2002;10:324-336 https://doi.org/10.1080/10673220216231
  9. Chenevert TL, Brunberg JA, Pipe JG. Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo. Radiology 1990;177:401-405 https://doi.org/10.1148/radiology.177.2.2217776
  10. Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology 1996;201:637-648 https://doi.org/10.1148/radiology.201.3.8939209
  11. Jones DK, Horsfield MA, Simmons A. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med 1999;42:515-525 https://doi.org/10.1002/(SICI)1522-2594(199909)42:3<515::AID-MRM14>3.0.CO;2-Q
  12. Papadakis NG, Xing D, Huang CL, Hall LD, Carpenter TA. A comparative study of acquisition schemes for diffusion tensor imaging using MRI. J Magn Reson 1999;137:67-82 https://doi.org/10.1006/jmre.1998.1673
  13. Hasan KM, Parker DL, Alexander AL. Comparison of gradient encoding schemes for diffusion-tensor MRI. J Magn Reson Imaging 2001;13:769-780 https://doi.org/10.1002/jmri.1107
  14. Jones DK. The effect of gradient sampling schemes on measures derived from diffusion tensor MRI: a Monte Carlo study. Magn Reson Med 2004;51:807-815 https://doi.org/10.1002/mrm.20033
  15. Turner R, Le Bihan D, Chesnick AS. Echo-planar imaging of diffusion and perfusion. Magn Reson Med 1991;19:247-253 https://doi.org/10.1002/mrm.1910190210
  16. Anderson AW, Gore JC. Analysis and correction of motion artifacts in diffusion weighted imaging. Magn Reson Med 1994;32:379-387 https://doi.org/10.1002/mrm.1910320313
  17. Ordidge RJ, Helpern JA, Qing ZX, Knight RA, Nagesh V. Correction of motional artifacts in diffusion-weighted MR images using navigator echoes. Magn Reson Imaging 1994;12:455-460 https://doi.org/10.1016/0730-725X(94)92539-9
  18. Papadakis NG, Martin KM, Mustafa MH, Wilkinson ID, Griffiths PD, Huang CL, et al. Study of the effect of CSF suppression on white matter diffusion anisotropy mapping of healthy human brain. Magn Reson Med 2002;48:394-398 https://doi.org/10.1002/mrm.10204
  19. Yamada K, Kizu O, Mori S, Ito H, Nakamura H, Yuen S, et al. Brain fiber tracking with clinically feasible diffusion-tensor MR imaging: initial experience. Radiology 2003;227:295-301 https://doi.org/10.1148/radiol.2271020313
  20. Okada T, Miki Y, Fushimi Y, Hanakawa T, Kanagaki M, Yamamoto A, et al. Diffusion-tensor fiber tractography: intraindividual comparison of 3.0-T and 1.5-T MR imaging. Radiology 2006;238:668-678 https://doi.org/10.1148/radiol.2382042192
  21. Nagae-Poetscher LM, Jiang H, Wakana S, Golay X, van Zijl PC, Mori S. High-resolution diffusion tensor imaging of the brain stem at 3 T. AJNR Am J Neuroradiol 2004;25:1325-1330
  22. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, et al. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 2001;13:534-546 https://doi.org/10.1002/jmri.1076
  23. Douek P, Turner R, Pekar J, Patronas N, Le Bihan D. MR color mapping of myelin fiber orientation. J Comput Assist Tomogr 1991;15:923-929 https://doi.org/10.1097/00004728-199111000-00003
  24. Mori S, Crain BJ, Chacko VP, van Zijl PC. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 1999;45:265-269 https://doi.org/10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3
  25. Behrens TE, Woolrich MW, Jenkinson M, Johansen-Berg H, Nunes RG, Clare S, et al. Characterization and propagation of uncertainty in diffusion-weighted MR imaging. Magn Reson Med 2003;50:1077-1088 https://doi.org/10.1002/mrm.10609
  26. Behrens TE, Berg HJ, Jbabdi S, Rushworth MF, Woolrich MW. Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? Neuroimage 2007;34:144-155 https://doi.org/10.1016/j.neuroimage.2006.09.018
  27. Oishi K, Zilles K, Amunts K, Faria A, Jiang H, Li X, et al. Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter. Neuroimage 2008;43:447-457 https://doi.org/10.1016/j.neuroimage.2008.07.009
  28. Lee JS, Han MK, Kim SH, Kwon OK, Kim JH. Fiber tracking by diffusion tensor imaging in corticospinal tract stroke: Topographical correlation with clinical symptoms. Neuroimage 2005;26:771-776 https://doi.org/10.1016/j.neuroimage.2005.02.036
  29. Geyer S, Matelli M, Luppino G, Zilles K. Functional neuroanatomy of the primate isocortical motor system. Anat Embryol (Berl) 2000;202:443-474 https://doi.org/10.1007/s004290000127
  30. Guye M, Parker GJ, Symms M, Boulby P, Wheeler-Kingshott CA, Salek-Haddadi A, et al. Combined functional MRI and tractography to demonstrate the connectivity of the human primary motor cortex in vivo. Neuroimage 2003;19:1349-1360 https://doi.org/10.1016/S1053-8119(03)00165-4
  31. Laundre BJ, Jellison BJ, Badie B, Alexander AL, Field AS. Diffusion tensor imaging of the corticospinal tract before and after mass resection as correlated with clinical motor findings: preliminary data. AJNR Am J Neuroradiol 2005;26:791-796
  32. Lazar M, Alexander AL, Thottakara PJ, Badie B, Field AS. White matter reorganization after surgical resection of brain tumors and vascular malformations. AJNR Am J Neuroradiol 2006;27:1258-1271
  33. Lu S, Ahn D, Johnson G, Cha S. Peritumoral diffusion tensor imaging of high-grade gliomas and metastatic brain tumors. AJNR Am J Neuroradiol 2003;24:937-941
  34. Lu S, Ahn D, Johnson G, Law M, Zagzag D, Grossman RI. Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema: introduction of the tumor infiltration index. Radiology 2004;232:221-228 https://doi.org/10.1148/radiol.2321030653
  35. Powell HW, Parker GJ, Alexander DC, Symms MR, Boulby PA, Wheeler-Kingshott CA, et al. MR tractography predicts visual field defects following temporal lobe resection. Neurology 2005;65:596-599 https://doi.org/10.1212/01.wnl.0000172858.20354.73
  36. Jea A, Vachhrajani S, Widjaja E, Nilsson D, Raybaud C, Shroff M, et al. Corpus callosotomy in children and the disconnection syndromes: a review. Childs Nerv Syst 2008;24:685-692 https://doi.org/10.1007/s00381-008-0626-4
  37. Klatzo I. Pathophysiological aspects of brain edema. Acta Neuropathol 1987;72:236-239 https://doi.org/10.1007/BF00691095
  38. Davis D, Ulatowski J, Eleff S, Izuta M, Mori S, Shungu D, et al. Rapid monitoring of changes in water diffusion coefficients during reversible ischemia in cat and rat brain. Magn Reson Med 1994;31:454-460 https://doi.org/10.1002/mrm.1910310416
  39. Carano RA, Li F, Irie K, Helmer KG, Silva MD, Fisher M, et al. Multispectral analysis of the temporal evolution of cerebral ischemia in the rat brain. J Magn Reson Imaging 2000;12:842-858 https://doi.org/10.1002/1522-2586(200012)12:6<842::AID-JMRI7>3.0.CO;2-5
  40. Nelles M, Gieseke J, Flacke S, Lachenmayer L, Schild HH, Urbach H. Diffusion tensor pyramidal tractography in patients with anterior choroidal artery infarcts. AJNR Am J Neuroradiol 2008;29:488-493 https://doi.org/10.3174/ajnr.A0855
  41. Hosomi A, Nagakane Y, Yamada K, Kuriyama N, Mizuno T, Nishimura T, et al. Assessment of arcuate fasciculus with diffusion-tensor tractography may predict the prognosis of aphasia in patients with left middle cerebral artery infarcts. Neuroradiology 2009;51:549-555 https://doi.org/10.1007/s00234-009-0534-7
  42. McKinstry RC, Mathur A, Miller JH, Ozcan A, Snyder AZ, Schefft GL, et al. Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI. Cereb Cortex 2002;12:1237-1243 https://doi.org/10.1093/cercor/12.12.1237
  43. Eriksson SH, Symms MR, Rugg-Gunn FJ, Boulby PA, Wheeler-Kingshott CA, Barker GJ, et al. Exploring white matter tracts in band heterotopia using diffusion tractography. Ann Neurol 2002;52:327-334 https://doi.org/10.1002/ana.10295
  44. Hoon AH Jr, Lawrie WT Jr, Melhem ER, Reinhardt EM, Van Zijl PC, Solaiyappan M, et al. Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways. Neurology 2002;59:752-756 https://doi.org/10.1212/WNL.59.5.752
  45. Kapeller P, Schmidt R, Fazekas F. Qualitative MRI: evidence of usual aging in the brain. Top Magn Reson Imaging 2004;15:343-347 https://doi.org/10.1097/01.rmr.0000172668.02575.18
  46. Salat DH, Tuch DS, Greve DN, van der Kouwe AJ, Hevelone ND, Zaleta AK, et al. Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging 2005;26:1215-1227 https://doi.org/10.1016/j.neurobiolaging.2004.09.017
  47. Charlton RA, Barrick TR, McIntyre DJ, Shen Y, O'Sullivan M, Howe FA, et al. White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology 2006;66:217-222 https://doi.org/10.1212/01.wnl.0000194256.15247.83
  48. Medina D, DeToledo-Morrell L, Urresta F, Gabrieli JD, Moseley M, Fleischman D, et al. White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study. Neurobiol Aging 2006;27:663-672 https://doi.org/10.1016/j.neurobiolaging.2005.03.026
  49. Taoka T, Iwasaki S, Sakamoto M, Nakagawa H, Fukusumi A, Myochin K, et al. Diffusion anisotropy and diffusivity of white matter tracts within the temporal stem in Alzheimer disease: evaluation of the "tract of interest" by diffusion tensor tractography. AJNR Am J Neuroradiol 2006;27:1040-1045
  50. Matsuo K, Mizuno T, Yamada K, Akazawa K, Kasai T, Kondo M, et al. Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography. Neuroradiology 2008;50:605-611 https://doi.org/10.1007/s00234-008-0379-5
  51. Ganguli M, Dodge HH, Shen C, DeKosky ST. Mild cognitive impairment, amnestic type: an epidemiologic study. Neurology 2004;63:115-121 https://doi.org/10.1212/01.WNL.0000132523.27540.81
  52. Vaillancourt DE, Spraker MB, Prodoehl J, Abraham I, Corcos DM, Zhou XJ, et al. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology 2009;72:1378-1384 https://doi.org/10.1212/01.wnl.0000340982.01727.6e
  53. Kubicki M, McCarley R, Westin CF, Park HJ, Maier S, Kikinis R, et al. A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res 2007;41:15-30 https://doi.org/10.1016/j.jpsychires.2005.05.005
  54. Kyriakopoulos M, Bargiotas T, Barker GJ, Frangou S. Diffusion tensor imaging in schizophrenia. Eur Psychiatry 2008;23:255-273 https://doi.org/10.1016/j.eurpsy.2007.12.004
  55. Kanaan RA, Kim JS, Kaufmann WE, Pearlson GD, Barker GJ, McGuire PK. Diffusion tensor imaging in schizophrenia. Biol Psychiatry 2005;58:921-929 https://doi.org/10.1016/j.biopsych.2005.05.015
  56. Scollan DF, Holmes A, Winslow R, Forder J. Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging. Am J Physiol 1998;275:H2308-2318
  57. Lin CP, Tseng WY, Cheng HC, Chen JH. Validation of diffusion tensor magnetic resonance axonal fiber imaging with registered manganese-enhanced optic tracts. Neuroimage 2001;14:1035-1047 https://doi.org/10.1006/nimg.2001.0882
  58. Okada T, Mikuni N, Miki Y, Kikuta K, Urayama S, Hanakawa T, et al. Corticospinal tract localization: integration of diffusiontensor tractography at 3-T MR imaging with intraoperative white matter stimulation mapping--preliminary results. Radiology 2006;240:849-857 https://doi.org/10.1148/radiol.2403050916
  59. Hagmann P, Jonasson L, Maeder P, Thiran JP, Wedeen VJ, Meuli R. Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. Radiographics 2006;26 Suppl 1:S205-223 https://doi.org/10.1148/rg.26si065510

Cited by

  1. Serial MR Analysis of Early Permanent and Transient Ischemia in Rats: Diffusion Tensor Imaging and High b Value Diffusion Weighted Imaging vol.14, pp.2, 2011, https://doi.org/10.3348/kjr.2013.14.2.307
  2. Hypothalamic metabolic compartmentation during appetite regulation as revealed by magnetic resonance imaging and spectroscopy methods vol.5, pp.None, 2011, https://doi.org/10.3389/fnene.2013.00006
  3. Use of diffusion tensor imaging in glioma resection vol.34, pp.4, 2013, https://doi.org/10.3171/2013.1.focus12412
  4. Characteristics of Corticospinal Tract Area According to Pontine Level vol.54, pp.3, 2011, https://doi.org/10.3349/ymj.2013.54.3.785
  5. Morphometric and volumetric study of caudate and putamen nuclei in normal individuals by MRI: Effect of normal aging, gender and hemispheric differences vol.78, pp.3, 2011, https://doi.org/10.12659/pjr.889364
  6. Magnetic resonance imaging of the pelvic floor: From clinical to biomechanical imaging vol.227, pp.12, 2011, https://doi.org/10.1177/0954411913502952
  7. Use of Diffusion Tensor Imaging in the Resection of Gliomas vol.2, pp.10, 2011, https://doi.org/10.1007/s40137-014-0069-7
  8. Patterns of cortical thinning in idiopathic rapid eye movement sleep behavior disorder vol.30, pp.5, 2011, https://doi.org/10.1002/mds.25820
  9. A Study of volumetric variations of basal nuclei in the normal human brain by magnetic resonance imaging vol.30, pp.2, 2011, https://doi.org/10.1002/ca.22813
  10. Abnormal white matter integrity in Chinese young adults with first-episode medication-free anxious depression: a possible neurological biomarker of subtype major depressive disorder vol.14, pp.None, 2011, https://doi.org/10.2147/ndt.s169583
  11. A probabilistic atlas of human brainstem pathways based on connectome imaging data vol.169, pp.None, 2011, https://doi.org/10.1016/j.neuroimage.2017.12.042
  12. Visualization of peri-prostatic neurovascular fibers before and after radical prostatectomy by means of diffusion tensor imaging (DTI) with clinical correlations: preliminary report vol.14, pp.2, 2011, https://doi.org/10.1007/s11701-019-00998-z
  13. Evaluation of White Matter Tracts Fractional Anisotropy Using Tract-Based Spatial Statistics and Its correlation with Amyotrophic Lateral Sclerosis Functional Rating Scale Score in Patients with Motor vol.31, pp.2, 2011, https://doi.org/10.1055/s-0041-1734337
  14. Strain Tensor Imaging: Cardiac-induced brain tissue deformation in humans quantified with high-field MRI vol.236, pp.None, 2011, https://doi.org/10.1016/j.neuroimage.2021.118078