Acquired Dyschromatopsia among Workers Exposed to Acetone and Isopropyl Alcohol (IPA)

아세톤과 이소프로필알콜(IPA) 노출 근로자들의 후천성 색각이상

  • 김승환 (순천향대학교 천안병원 산업의학과) ;
  • 황광모 (순천향대학교 천안병원 산업의학과) ;
  • 장은철 (순천향대학교 천안병원 산업의학과) ;
  • 김찬윤 (연세대학교 의과대학 안과학교실) ;
  • 박신구 (인하대학교 의과대학 부속병원 산업의학과) ;
  • 이은희 (극동대학교 안경광학과) ;
  • 노재훈 (연세대학교 의과대학 예방의학교실)
  • Published : 2011.12.31

Abstract

Objectives: The purpose of this study was to examine the correlation between exposure to acetone and isopropyl alcohol (IPA) and the acquisition dyschromatopsia. Methods: A study was performed on exposure group of 116 people exposed to and a group of 36 people not exposed to organic solvents were selected and examined. Their smoking and alcohol habits, symptoms, and exposure history were surveyed through questionnaires and interviews. Then dyschromatopsia was evaluated with the Lanthony D-15 d test in a room with standardized intensity of illumination. Results: The statistical prevalence of dyschromatopsia was significantly higher in the exposed group (30.2%) compared to that found in the control group (19.4%). Out of the 116 subjects in the exposed group, 30 people had acquired dyschromatopsia (25.86%). The variables affecting the color confusion index, such as age, exposure, and the duration of exposure, were statistically significant variables. Conclusions: he prevalence of dyschromatopsia was found to be not significantly higher in the group with exposure to organic solvents compared to that found in the control group. In addition, a statistically significant correlation was found between exposure to organic solvents and the color confusion index.

목적: 아세톤 및 이소프로필알콜(IPA)에 혼합 노출되는 근로자를 대상으로 노출여부와 후천성 색각이상간에 연관성을 조사하기 위해 본 연구를 실시하였다. 방법: 일개 지역 아세톤 및 IPA 노출 근로자들 가운데 노출군 116명과 유기화합물에 노출되지 않는 비노출군 36명을 대상으로 조사하였다. 설문지 및 면담을 통해 흡연유무, 음주유무, 과거력 및 증상유무와 노출력을 조사하고, 조도가 표준화된 방에서 Lanthony D-15d검사를 이용하여 색각이상을 평가였다. 결과: 색각이상의 유병률은 노출군(30.2%), 비노출군 (19.4%)으로 차이가 있었으나 통계적으로 유의하지 않았으며, 유기화합물 노출군 116명 가운데 후천적 색각이상인 청황색색각이상자가 30명(25.86%)이었다. 색혼란지수에 영향을 줄 수 있는 변수중 노출유무가 통계적으로 유의한 변수였다. 결론: 유기화합물 노출여부와 색혼란지수 간에 통계적으로 유의한 연관성을 보이고, 유기화합물 노출군에서 색각이상의 유병률이 비노출군보다 높았으나 유의하지 않았다. 정량적인 평가가 색각검사를 이용한 조기선별검사에 활용에 도움이 될 것으로 판단된다.

Keywords

References

  1. Ramu A, Rosenbaum J, Blaschke T. Dispostion of acetone following acute acetone intoxication. West J Med 1978;129:429-32.
  2. Bruckner JV, Peterson RG. Evaluation of toluene and acetone inhalant abuse. Toxicol Appl Pharmacol 1987;61:27-38.
  3. LoSasso G, Rapport L, Axelrod B, Whitman RD. Neurocognitive sequelae of exposure to organic solvents and (meth) acrylates among nail-studio technicians. Neuropsychiatry Neuropsychol Behav Neurol 2002;15:44-55.
  4. Joseph LaDou. Occupational and Environmental Medicine. 4rd ed. MacGraw-Hill Companies Inc. United States of America. 2007. pp 486-95.
  5. Campagna D, Mergler D, Huel G, Belanger S, Truchon G, Ostiguy C, et al. Visual dysfunction among styreneexposed worker. Scand J Work Environ Health 1995;21(5):382-90. https://doi.org/10.5271/sjweh.53
  6. Joo IS, Kim JS, Huh K, Kim JI, Lee KJ, Chung HK, et al. Cognitive impairment and peripheral neuropathy by mixed organic solvents in spray painters working in a shipbuilding industry. J Korean Neurol Assoc 2000;18(3):311-8. (Korean)
  7. Sakong J, Chung JH, Lee HY. Interrelation of neuropsychiatric symptom and neurobehavioral test among workers exposed to organic solvents. Korean J Occup Med 1997;9(1):49-60. (Korean)
  8. Kim SS, Cheong HK, Kwon YW. Evaluation of early neurologic abnormalities on the workers exposed to acrylamade. Korean J Occup Environ Med 2000;12(3):367-83. (Korean)
  9. Kang MJ, Kang SH, Suh SK, Shin DH, Lee JY. The assessment of acquired dyschromatopsia among organic- solvents exposed workers. Korean J Prev Med 1996;29(3):529-38. (Korean)
  10. Byun JH, Lee KY, Kim YK, Ko KW, Lee YH. Acquired dyschromatopsia in women workers in shoe manufacturing who were exposed organic solvents. Korean J Occup Environ Med 2001;13(3):232-41. (Korean)
  11. Lee EH, Eum KD, Cho SI, Cheong HK, Paek DM. Acquired dyschromatopsia among petrochemical industry workers exposed to benzene. Neurotoxicology 2007;28(2):356-63. https://doi.org/10.1016/j.neuro.2006.05.005
  12. Paallysaho J, Nasanen R, Mantyjarvi M, Kaukiainen A, Sainio M. Colour vision defects in occupational chronic solvent encephalopathy. Hum Exp Toxicol 2007;26(4):375-83. https://doi.org/10.1177/0960327107076820
  13. Sizemore OJ, Amler RW. Characteristics of ATSDR's adult and pediatric environmental neurobehavioral test batteries. Neurotoxicology 1996;17(1):229-36.
  14. Urban P, Pelclova D, Lukas E, Kupka K, Preiss J, Fenclova Z, Smerhovsky Z. Neurological and neurophysiological examinations on workers with chronic poisoning by 2,3,7,8-TCDD: follow-up 35 years after exposure. Eur J Neurol 2007;14(2):213-8. https://doi.org/10.1111/j.1468-1331.2006.01618.x
  15. Gobba F, Cavalleri A. Color vision impairment in workers exposed to neurotoxic chemicals. Neurotoxicology 2004;25(5):803-16. https://doi.org/10.1016/j.neuro.2004.01.006
  16. Zavalic M, Mandic Z, Turk R, Bogadi-Sare A, Plavec D. Quantitative assessment of color vision impairment in workers exposed to toluene. Am J Ind Med 1998;33(3):297-304. https://doi.org/10.1002/(SICI)1097-0274(199803)33:3<297::AID-AJIM12>3.0.CO;2-V
  17. Raitta C, Seppalainen AN, Huuskonen MS. N-Hexane maculopathy in industrial workers. Graefe Arch Clin Exp Ophthamol 1978;209(2):99-110. https://doi.org/10.1007/BF00407843
  18. Wang C, Tan X, Bi Y, Su Y, Yan J, Ma S, et al. Crosssectional study of the ophthalmological effects of carbon disulfide in Chinese viscose workers. Int J Hyg Environ Health 2002;205(5):367-72. https://doi.org/10.1078/1438-4639-00168
  19. Mergler D, Blain L, Lagace JP. Solvent related colour vision loss: An indicator of neural damage? Int Arch Occup Environ Health 1987;59(4):313-21. https://doi.org/10.1007/BF00405275
  20. Cavalleri A, Belotti L, Gobba F, Luzzana G, Rosa P, Seghizzi P. Colour vision loss in workers exposed to elemental mercury vapour. Toxicol Lett 1995;77(1-3):351-6. https://doi.org/10.1016/0378-4274(95)03317-3
  21. Sung IS, Kwon OY, Kang HY, Kim DH, Kim YS, Park KJ, Choi NC, Lim BH. A case of parkinsonism caused by acetone intoxication. J Korean Neurol Assoc 2003;21(4):422-4. (Korean)
  22. Park SH, Shin JA, Park HH, Yi GY, Chung KJ, Park HD, Kim KB, Lee IS. Exposure to volatile organic compounds and possibility of exposure to by-product volatile organic compounds in photolithography processes in semiconductor manufacturing factories. Saf Health Work 2011;2:210-7. https://doi.org/10.5491/SHAW.2011.2.3.210
  23. Calleman CJ, Wu Y, He F, Tian G, Bergmark E, Zhang S, Deng H, Wang Y, Crofton KM, Fennell T, et al. Relationships between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide. Toxicol Appl Pharmacol 1994;126(2):361-71. https://doi.org/10.1006/taap.1994.1127
  24. Geller AM. A table of color distance scores for quantitative scoring of the Lanthony Desaturate color vision test. Neurotoxicol Teratol 2001;23(3):265-7. https://doi.org/10.1016/S0892-0362(01)00139-8
  25. Anger WK, Letz R, Chrislip DW, Frumkin H, Hudnell K, Russo JM, Chappell W, Hutchinson L. Neurobehavioral test methods for environmental health studies of adults. Neurotoxicol Teratol 1994;16(5):489-97. https://doi.org/10.1016/0892-0362(94)90128-7
  26. Lanthony P. Evaluation of the desaturated panel D-15. IV. Effect of the repetition of desaturated panel D-15. J Fr Ophtalmol 1995;18(10):578-83.
  27. Ptratt-Johnson JA. Retrobulbar neuritis following exposure to vinyl bezene(styene). Can Med Ass J 1964;90:975-7.
  28. Horan Jm, Kurt TL, Landrigan PJ, Melius JM, Signal M. Neurologic dysfunction form exposure to 2-t-butylazo- 2-hydroxy-5-methylhexane (BHMH): A new occupational neuropathy. Am J Public Health 1985;75(5):513-7. https://doi.org/10.2105/AJPH.75.5.513
  29. Verriest G. Further studies on acquired deficiency of colour discrimination, J. Opt Soc Am 1963;53:185-95. https://doi.org/10.1364/JOSA.53.000185
  30. Mergler D. Neurotoxicology of the visual system. In: Bleeker ML, Hansen JA(eds) Colour Vision Deficiencies X. Kluwer. Dordrecht. 1991. pp 161-5.
  31. Muttray A, Wolff U, Jung D, Konietzko J. Blue-yellow deficiency in workers exposed to low concentrations of organic solvents. Int Arch Occup Environ Health 1997;70(6):407-12. https://doi.org/10.1007/s004200050237
  32. Valic E, Waldhor T, Konnaris C, Michitsch A, Wolf C. Acquired dyschromatopsia in combined exposure to solvents and alcohol. Int Arch Occup Environ Health 1977;70(6):403-6.
  33. Baird B, Camp J, Daniell W, Antonelli J. Solvents and color discrimination ability. Nonreplication of previous findings. J Occup Med 1994l;36(7):747-51.
  34. Gobba F, Galassi C, Imbriani M, Ghittori S, Candela S, Cavalleri A. Acquired dyschromatopsia dyschromatopsia among styrene-exposed workers. J Occup Med 1991;33(7):761-5. https://doi.org/10.1097/00043764-199107000-00006
  35. Park JW, Lee SY, Jang JY, Lee KJ, Jung HK. The relationship between the utilization of health center and exposed amount to solvent by using cumulative exposure index. Korean J Prev Med 1998;31(3):404-13. (Korean)