Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Malignant Retroperitoneal Paraganglioma in a Siberian Tiger

시베리아 호랑이에서 발생한 악성후복막부신경절종 증례

  • Shin, Sang-Kyung (College of Veterinary Medicine, Chungbuk National University) ;
  • Park, Byung-Min (College of Veterinary Medicine, Chungbuk National University) ;
  • Youm, So-Young (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Tae-Wang (College of Veterinary Medicine, Chungbuk National University) ;
  • Na, Ki-Jeong (College of Veterinary Medicine, Chungbuk National University) ;
  • Ahn, Byeong-Woo (College of Veterinary Medicine, Chungbuk National University)
  • Accepted : 2011.10.05
  • Published : 2011.10.31
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Abstract

A 14 year old female Siberian tiger presented for postmortem examination. A large mass attached to sublumbar area was found to be circumscribing aorta with metastases to mesenteric lymph nodes, uterus, kidney, adrenal gland, lung and thymus. The tumor cells were arranged in clusters or nests separated by well-developed fibrovascular stroma. The individual cells were plump and polygonal with granular eosinophilic cytoplasms and had distinct cell borders. The tumor cells were positive for synaptophysin, chromogranin A and neuron-specific enolase, and negative for cytokeratins, S100 and glial fibrillary acidic protein. The primary tumor was diagnosed as a malignant retroperitoneal paraganglioma.

조직병리소견과 면역염색결과를 바탕으로 14년령 암컷 시베리아 호랑이의 복막뒤공간에서 발생한 악성부신경절종을 보고하였다. 부신경절종은 동물에서 드물게 발생하는 신경내분비종양으로 주로 자율신경계의 부신외신경절 세포로부터 발생한다. 원발종괴는 복막뒤공간에 요추의 배쪽면을 따라 장방향으로 부착되어 있었고, 장간막림프절, 신장, 자궁, 부신, 폐, 흉선으로 전이되었다. 종양세포는 다각형의 통통한 형태에 과립상의 호산성 세포질을 갖고 있었으며, 섬유혈관 기질에 의해 구획되어 집락(cluster) 또는 둥지(nest) 모양으로 배열된 전형적인 Zell-ballen 형태를 나타냈다. 면역염색에서 synaptophysin, chromogranin A, neuron-specific enolase에 특이적인 양성반응을 보였다. 본 증례는 시베리아 호랑이에서 발생한 악성후복막부신경절종이 전신으로 전이된 최초보고이다.

Keywords

References

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