Journal of Microbiology and Biotechnology

  • 제21권3호
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  • Pages.263-266
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  • 2011
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Antiviral Activity of Methylelaiophylin, an ${\alpha}$-Glucosidase Inhibitor

  • Lee, Do-Seung (Faculty of Biotechnology, College of Applied Life Science, Jeju National University) ;
  • Woo, Jin-Kyu (Faculty of Biotechnology, College of Applied Life Science, Jeju National University) ;
  • Kim, Dong-Hern (Bio-Crop Division, Department of Agricultural Biotechnology, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Min-Young (Faculty of Biotechnology, College of Applied Life Science, Jeju National University) ;
  • Cho, So-Mi K. (Faculty of Biotechnology, College of Applied Life Science, Jeju National University) ;
  • Kim, Jae-Hoon (Faculty of Biotechnology, College of Applied Life Science, Jeju National University) ;
  • Park, Se-Pill (Faculty of Biotechnology, College of Applied Life Science, Jeju National University) ;
  • Lee, Hyo-Yeon (Faculty of Biotechnology, College of Applied Life Science, Jeju National University) ;
  • Riu, Key Zung (Faculty of Biotechnology, College of Applied Life Science, Jeju National University) ;
  • Lee, Dong-Sun (Faculty of Biotechnology, College of Applied Life Science, Jeju National University)
  • 투고 : 2010.11.02
  • 심사 : 2010.12.23
  • 발행 : 2011.03.28
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초록

Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an ${\alpha}$-glucosidase inhibitor with an $IC_{50}$ value of 10 ${\mu}M$. It showed mixed-type inhibition of ${\alpha}$-glucosidase with a $K_i$ value of 5.94 ${\mu}M$. In addition, methylelaiophylin inhibited the intracellular trafficking of hemagglutinin-neuramidase (HN), a glycoprotein of Newcastle disease virus (NDV), in baby hamster kidney (BHK) cells. Methylelaiophylin inhibited the cell surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.

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참고문헌

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