Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Fabrication of Biodegradable Polyphosphazene Microparticles by Electrohydrodynamic Atomization

전기분무에 의한 생분해성 폴리포스파젠 마이크로입자의 제조

  • Xue, Li-Wei (State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology) ;
  • Cai, Qing (State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology) ;
  • Ryu, Seung-Kon (Department of Chemical Engineering, Chungnam National University) ;
  • Jin, Ri-Guang (State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology)
  • ;
  • ;
  • 유승곤 (충남대학교 화학공학과) ;
  • Received : 2011.02.14
  • Accepted : 2011.04.12
  • Published : 2011.09.25
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Abstract

Biodegradable poly[(glycine ethyl ester)-(phenylalanine ethyl ester) phosphazene](PGPP) microparticles were fabricated by electrohydrodynamic atomization to apply drug release test. Atomization parameters such as applied voltage, polymer concentration, and molecular weight were investigated to inspect their effects on the size and morphology of microparticles. The average diameter of PGPP microparticles decreased as increasing applied voltage and solution flow rate. Dichloromethane/dioxane mixture shows better results for the preparation of microparticles than single solvent owing to the different PGPP solubility in solvent. Blending PGPP polymers with proper molecular weights not only favored the production of spherical PGPP microparticles via electrohydrodynamic atomization, but also provided a way to adjust drug (rifampicin) release behavior. Drug-loaded biodegradable polyphosphazene microspheres can be fabricated via electrohydrodynamic atomization, which has potential use in biomedical applications.

Keywords

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