대한약침학회지 (Journal of Pharmacopuncture)

  • 제14권4호
  • /
  • Pages.5-11
  • /
  • 2011
  • /
  • 2093-6966(pISSN)
  • /
  • 2234-6856(eISSN)
대한약침학회 (KOREAN PHARMACOPUNCTURE INSTITUTE)
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허혈로 유발된 토끼의 급성 신부전에 대한 甘草(감초) 약침액 정맥 주입의 영향

Effects of Glycyrrhizae Radix Pharmacopuncture Intravenous Injection on Ischemia-Induced Acute Renal Failure in Rabbits

  • 김형철 (동의대학교 한의과대학) ;
  • 김경호 (부산대학교 한의학전문대학원) ;
  • 이금산 (부산대학교 한의학전문대학원) ;
  • 김형우 (부산대학교 한의학전문대학원) ;
  • 임세현 (극동대학교 간호학과) ;
  • 임지연 (동국대학교 의과대학 의학과) ;
  • 김영균 (동의대학교 한의과대학) ;
  • 조수인 (부산대학교 한의학전문대학원)
  • Kim, Hyeong-Cheol (Dong-Eui University College of Oriental Medicine) ;
  • Kim, Gyoung-Ho (Pusan National University School of Korean Medicine) ;
  • Lee, Guem-San (Pusan National University School of Korean Medicine) ;
  • Kim, Hyung-Woo (Pusan National University School of Korean Medicine) ;
  • Lim, Se-Hyun (Department of Nursing, Far East University College of Public Health) ;
  • Lim, Chi-Yeon (Department of Medicine, Dongguk University College of Medicine) ;
  • Kim, Young-Gyun (Dong-Eui University College of Oriental Medicine) ;
  • Cho, Su-In (Pusan National University School of Korean Medicine)
  • 투고 : 2011.09.04
  • 심사 : 2011.11.02
  • 발행 : 2011.12.30
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초록

Objectives: The present study was undergone to determine whether Glycyrrhizae Radix pharmacopuncture intravenous injection exerts beneficial effect against the ischemia-induced acute renal failure in rabbits. Methods: Rabbits were treated with Glycyrrhizae Radix pharmacopuncture via i.v., followed by renal ischemia/reperfusion. The fractional excretion of glucose and phosphate were measured and the malondialdehyde content was also determined. The morphological changes of cortical part of kidney also observed with light microscope. Results: Renal ischemia/reperfusion caused increase of the fractional excretion of glucose and phosphate in ischemia-induced animals, which was prevented by Radix Glycyrrhizae extract treatment. Ischemia/reperfusion increased lipid peroxidation, which was prevented and morphological changes also altered by Radix Glycyrrhizae pharmacopuncture administration. Conclusions: These results indicate that lipid peroxidation plays a critical role in ischemia-induced acute renal failure and Glycyrrhizae Radix pharmacopuncture exerts the protective effect against acute renal failure induced by renal ischemia/reperfusion.

키워드

과제정보

연구 과제 주관 기관 : Pusan National University

참고문헌

  1. Guh JY, Chen HC, Tsai JF and Chuang LY. Herbal herapy is associated with the risk of CDK in adults not using analgesics in Taiwan. Am. J. Kidney Disl. 2007;49(5):626-33. https://doi.org/10.1053/j.ajkd.2007.02.259
  2. Doo HK. Nephrology in Korean Medicine. Seoul: Sungbosa. 1990:425-7, 437.
  3. Training Center for Medical Education. Home Medical. Seoul: Seoul Natl. Univ. Press. 1995:407.
  4. Kim MH, Park CH, Kim HE and Yun YC. Effect of Acupuncture and Moxibustion at SP6 (Sanyinjiao) and BL28 (Pangguangshu) on Experimental Acute renal failure in rats. The Journal of Korean Acupuncture & Moxibustion Society. 2002;19(6):49-60.
  5. Fang YZ. Practical Chinese Internal Medicine. Shanghai: Shanghai Sci. Tech. Publish. 1986:287-9.
  6. Cho DK. Pathophysiology of Ischemic Acutr Renal Failure. The Korean Journal of Nephrology. 1997;16(2):189-98.
  7. Chung TS, Kim CS, Jhin TK and Seok J. Changes of Na-K ATPase during Acute Ischemic Renal Failure. The Korean Journal of Nephrology. 1993;12(3):295-303.
  8. Kim SY, Ham SC, Yoo HJ and Kim YK. Benificial effect of verapamil against ischemic acute renal failure in rabbits. The Korean Journal of Nephrology. 1998;17(4):533-44.
  9. Korean Herbology Compilation Committee. Korean Herbology. Seoul:Younglimsa. 2007:583-5.
  10. Ahn EY, Shin DH, Baek NI and Oh JA. Isolation and Identification of Antimicrobial Active Substance from Glycyrrhiza uralensis FISCH. KOREAN J. FOOD SCI. TECHNOL. 1998;140:680-7.
  11. Lim TW, Lee JW and Lee MH. Effects of Licorice Extract on Proliferation and Melanization in Cultured Normal Human Melanocytes. J. Kyung Hee Univ. Med. Cent. 2000;16(2):143-50.
  12. Lee JS, Kim HA, Cho SH, Son AR, Jang TS, So MS, Chung SR and Lee SH. Tyrosinase Inhibitors isolated from the Roots of Glycyrrhiza glabra L.. Kor. J. Pharmacogn. 2003;34(1):33-9.
  13. Kang KW, Lee KJ, Yoon HS, Cho YS, Kim SB, Lee S and Jung SH. Acute myocardial infarction coincident with gastric ulcer bleeding following herbal medication-induced acute renal failure. The Korean Journal of Internal Medicine. 2010;78(3):364-9.
  14. Cho SI, Kim GH, Kim MH, Yun YC and Kin YG. Beneficial Effect of Glycyrrhizae Radix Extract on Ischemia-Induced Acute Renal Failure in Rabbits. Kor. J. Herbology. 2005;20(3):43-9.
  15. Uchiyama M and Mihara M. Determination of malonaldehyde precusor in tissue by thiobarbituric acid test. Anal. Biochem. 1987;86:271-8.
  16. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dry binding. Anal. Biochem. 1976;72:248-524. https://doi.org/10.1016/0003-2697(76)90527-3
  17. Yoon TS, Cheon MS, Kim SJ, Lee AY, Moon BC, Chun JM, Choo BK and Kim HK. Evaluation of Solvent Extraction on the Anti- Inflammatory Efficacy of Glycyrrhiza uralensis. Korean J. Medicinal Crop Sci. 2010;18(1):28-33.
  18. Lee KH and Rhee KH. Anti-Inflammatory Effects of glycyrrhiza glabra Linne Extract in a Dextran Sulfate Sodium-Induced Colitis Mouse Model. Korean J. Food & Nutr. 2010;23(4):435-9.
  19. Park KA, Seok SJ, Kim SJ, Gil HW, Yang JO, Lee EY and Hong SY. A Case of Licorice- Induced Hypokalemic Rhabdomyolysis in a Patient Using a Diuretic Drug. The Korean Journal of Internal Medicine. 2011;80(2):258-62.
  20. Park JS, Park KA, Gil HW, Yang JO, Lee EY and Hong SY. A Case Report of Small Amount of Licorice-Induced Hypokalemic Rhabdomyolysis in a Patient Using a Diuretic Drug. The Korean Journal of Internal Medicine. 2010;Autumn Special Issue:273.
  21. Wang JK, Kim JY, Cha JJ, Oh SW, Park SW, Kim JS, Yee YM, Lee JE, Won NH, Kwon YJ and Pyo HJ. A Case of Licorice-Induced Hypokalemia. The Korean Journal of Nephrology. 2008;27(1):S285.
  22. College of Medicine of Seoul National University. Nephrology. Seoul:Seoul National University Press. 1999:277-80.
  23. Farber JL, Kyle ME and Coleman JB. Biology of disease. Mechanism of cell injury by activated oxygen species. Lab. Invest. 1990;62:670-9.