The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Enhancing the Immunogenicity of Platycodon Grandiflorum on Adaptive Immune System

길경(桔經)의 적응면역계(適應免疫界) 증강(增强) 효과(效果)

  • Park, Joon-Hong (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Jin-Moo (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Chang-Hoon (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung-Hee University) ;
  • Cho, Jung-Hoon (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung-Hee University) ;
  • Jang, Jun-Bock (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Khung-Sub (Dept. of Oriental Gynecology, College of Oriental Medicine, Kyung-Hee University)
  • 박준홍 (경희대학교 한의과대학 한방부인과 교실) ;
  • 이진무 (경희대학교 한의과대학 한방부인과 교실) ;
  • 이창훈 (경희대학교 한의과대학 한방부인과 교실) ;
  • 조정훈 (경희대학교 한의과대학 한방부인과 교실) ;
  • 장준복 (경희대학교 한의과대학 한방부인과 교실) ;
  • 이경섭 (경희대학교 한의과대학 한방부인과 교실)
  • Received : 2010.10.25
  • Accepted : 2010.11.09
  • Published : 2010.11.30
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Abstract

Purpose: This study was designed to investigate enhancing the immunogenicity effects of Platycodon grandiflorum(PG) on adaptive immune system. Methods: To investigate the effect of PG as an adjuvant, we used the ovalbumin (OVA) as an antigen at first. The proliferation of lymphocytes, the antibody titer, the subisotypes of antibodies and the production of cytokines were measured. Results: The proliferation of lymphocytes and the antibody titer were increased after PG treatment. The increased subisotypes of antibodies were IgG2 and IgG3 induced from T1-helper cells. However IgE induced from T2-helper cells was decreased. The production of cytokines derived from T1-helper cells was increased but that from T2-helper cells was decreased. Conclusion: It is supposed that PG has an immunogenicity effect as an adjuvant on adaptive immune system.

Keywords

References

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