랫드에 투여된 규회석이 호흡기계에 미치는 영향 연구

Toxicity study of Wollastonite to the Respiratory Systems in Sprague-Dawely Rats

  • 정용현 (산업안전보건연구원 화학물질안전보건센터) ;
  • 한정희 (산업안전보건연구원 화학물질안전보건센터) ;
  • 강민구 (산업안전보건연구원 화학물질안전보건센터) ;
  • 이성배 (산업안전보건연구원 화학물질안전보건센터) ;
  • 김종규 (산업안전보건연구원 화학물질안전보건센터) ;
  • 김현영 (산업안전보건연구원 화학물질안전보건센터) ;
  • 양정선 (산업안전보건연구원 화학물질안전보건센터)
  • Chung, Yong-Hyun (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Han, Jeong-Hee (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kang, Min-Gu (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Lee, Sung-Bae (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kim, Jong-Kyu (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kim, Hyeon-Yeong (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Yang, Jung-Sun (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute)
  • 투고 : 2010.03.11
  • 심사 : 2010.10.18
  • 발행 : 2010.12.31

초록

Occupational exposure to wollastonite can occur during its mining, processing and using. Wollastonite was analyzed for its physicochemical properties by transmission electron microscope and scanning electron microscope equipped with energy dispersive X-ray spectrometer. Wollastonite fibers were 3.3${\mu}m$ in diameter(av.) and were 30.5${\mu}m$ in length(av.). The atomic composition of wollastonite was Si 56.41% and Ca 43.59%. Respiratory toxicity of wollastonite has been studied in term sequential in Sprague-Dawely rats. UICC chrysotile (average diameter 0.03${\mu}m$, average length 2.93${\mu}m$) was applied as the positive control. The effects of 2mg wollastonite on respiratory system and pathological changes were evaluated after 1, 4, 8, 12 weeks instilled into rat lungs. Inflammation response broke out from 1 week after instilled with wollastonite and the pathological examination further showed increased legions of granulomatous inflammation after 4 weeks, but decreased granulomatous inflammation after 8 weeks, whereas chrysotile induced progressive interstitial granulomatous inflammation and fibrosis as a function of time.

키워드

참고문헌

  1. Adachi S, Kawamura K and Takemoto K. A trial on the quantitative risk assessment of man-made mineral fibers by the rat intraperitoneal administration assay using the JFM standard fibrous samples. Ind. Health 2001;39:168-174. https://doi.org/10.2486/indhealth.39.168
  2. Anonymous. The trouble with tremolite-asbestiform mineral casts its shadow over wollastonite. Ind. Miner. 2002;420:7.
  3. Anonymous. China makes paper with ore powder. People's Online Daily, June 13. Available online at: http://english.people.com.cn/200306/13/eng20030613-118153.shtml. Last accessed on November 19, 2004.
  4. Aslam M, Arif MJ and Rahman O. Red blood cell damage by wollastonite: In vitro srudy. J. Appl Toxicol. 1995;15(1):27-31. https://doi.org/10.1002/jat.2550150107
  5. Bank W. Asbestiform and/or fibrous minerals in mines, mills, and quarries, Pub No 1980-603-120/34, Washington, DC, US Department of Labor, Mine Safety and Health Administration. 1980.
  6. Bellmann B, Muhle H, Kamstrup O, Graeger UF. Investigation of the biodurability of man made vitreous fibers ion rat lungs. Environ Health perspect. 1997;102(suppl 5):185-189.
  7. Bellmann B and Muhle H. Investigation of the biodurability of wollastonite and xonotlite. Environ. Health Perspect. 1994;102(suppl. 5):191-195. https://doi.org/10.1289/ehp.94102s6191
  8. Bernstein DM, Riego sinites JM, Ersboell, BK, Kunert J. Biopersistence of synthetic mineral fibers as a predictor of chronic inhalation toxicity in rats. Inhal. Toxicol. 2001:13:823-849. https://doi.org/10.1080/089583701752378133
  9. Cambelova M and Juck A. Fibrogenic effect of wollastonite compared with asbestos dust and dusts containing quartz. Occup. Environ. Med. 1994;51:343-346. https://doi.org/10.1136/oem.51.5.343
  10. CNX marketlink. Fording Inc. announces 2002 third quarter results and dividend. Available electronically at http://www.cnxmarketlink.com/en/releases/archive/October2002/22/c3672.html, last accessed November 14, 2004
  11. DiFrancesco CA and Virta RL. Wollastonite statistics. Reston, VA:U.S. Geological Survey. 2004.
  12. Fattah H. Wollastonite: New aspects promise growth. Ind. Miner. 1994;November, 21-43.
  13. Hanke W and Sepulveda MJ. Health hazard evaluation determination report. NYCO, Willsboro,NY(MHETA 81-112). Cincinnati, OH:NIOSH. 1983.
  14. Hanke W, Sepulveda MJ, Watson A and Jankovic J. Respiratory morbidity in wollastonite workers. Br. J. Ind. Med. 1984;4:474-479.
  15. Huuskonen M, Tossavaien A, Koskinen H, Zitting A, Korhonen O, Jickels J, Korhonen K and Vaaranen V. Respiratory morbidity of quarry workers exposed to wollastonite(Abstract). In Proceeding of the International Conference on Occupational Lung Diseases. Chicago. Park Ridge, JL: American College of Chest Physicians. March 1982.p.24-27
  16. Huuskonen M, Tossavaien A, Koskinen H, Zitting A, Korhonen O, Jickels J, Korhonen K and Vaaranen V. Wollastonite exposure and lung fibrosis. Environ. Res. 1983b;30:291-304. https://doi.org/10.1016/0013-9351(83)90215-3
  17. Huuskonen M, Jarvisalo J, Koskinen H, Nickels J, Rasanen J and Asp S. Preliminary results from a cohort of workers exposed to wollastonite in a Finnish limestone quarry. Scand. J. Work Envirion. Health. 1983a;9:169-175. https://doi.org/10.5271/sjweh.2438
  18. Huuskonen M and Tossavainen A. Health effects associated with wollastonite exposure. J. Occup. Health Safety-Aust. NZ. 1996;12(3):357-360.
  19. IARC. Silica, some silicates, coal dust, and para-aramide fibrils. IARC Monogr. Eval. Carcinogen. Risk Chem. Hum. 1997;68.
  20. Koskinen HO, Nordman HL, Zitting AJ, Suranta HT, Anttila SL, Taikina-aho OS and Luukkonen RA. Fibrosis of the lung and pleura and long-term exposure to wollastonite. Scand. J. Work Environ. Health. 1997;23:41-47. https://doi.org/10.5271/sjweh.177
  21. Law BD, Bunn WB and Hesterberg TW. Solubility of polymeric organic fibers and manmade vitreous fibers in Gambles solution. Inhalation Toxicol. 1990;2:231-339 https://doi.org/10.3109/08958379009145261
  22. Lippmann M. Man-made mineral fibers (MMMF): human exposures and health risk assessment. Toxicol Ind Health. 1990;6:225-246.
  23. Lockey JE and Wiese NK. Health effects of synthetic vitreous fibers. Clin Chest Med. 1992;13:329-339.
  24. Lockey JE. 1995. Man-made fibers and nonasbestos fibrous silicates, In Occupational and environmental respiratory disease. eds. Philip Harber, Marc B. Schenker, John R. Balmes. Mosby. 1995;p.330-344.
  25. Macdonald JL and Kane AB. Mesothelial cell proliferation and biopersistence of wollastonite and crocidolite asbestos fibers. Fundam. Appl. Toxicol. 1997;38(2):173-183. https://doi.org/10.1006/faat.1997.2344
  26. Maxim LD & McConnell EE. A review of the toxicology and epidemiology of wollastonite. Inhalation Toxicology. 2005;17:451-466. https://doi.org/10.1080/08958370591002030
  27. McConnell EE. Fibrogenic effect of wollastonite compared with asbestos dusts and dusts containing quartz. Letter to the editor. Occup. Environ. Med. 1995;52:621.
  28. McConnell EE, Hall L, and Adkins B Jr. Studies on the chronic toxicity(inhalation) of wollastonite in Fischer 344 rats. Inhal. Toxicol. 1991;3:323-337. https://doi.org/10.3109/08958379109145292
  29. Muhle H, Bellmann B and Pott F. Durability of various mineral fibers in rat lungs. In: Mechanism in fiber carcinogenesis. eds. Brown RC, Hoskins JA and Johnson NF. New York: Plenum Press. 1991. p.181-187.
  30. Muhle H, Bellmann B and Pott F. 1994. Comparative investigations of the biodurability of mineral fibers in the rat lung. Environ. Health Perspect. 1994;102(suppl. 5):163-168. https://doi.org/10.1289/ehp.94102s5163
  31. National Institute for Occupational Safety and Health. NIOSH pocket guide to chemical hazards: Calcium silicate. Available electronically at http://www.cdc.gov/niosh/npg/npgd0094.html. 2004.
  32. NYCO Minerals Inc. Background information on wollastonite posted on the web site http://www.nycominerals.com, last accessed 21 July 2004. 2004.
  33. Porter D, Hubbs AF, Mercer R, Robinson VA, Ramsey D, McLaurin J, Khan A, Battelli L, Brumbaugh K, Teass A and Castranova V. Progression of lung inflammation and damage in rats after cessation of silica inhalation. Toxicological science. 2004;79:370-380. https://doi.org/10.1093/toxsci/kfh110
  34. Pott F, Zeim U, Reiffer FJ, Huth F, Ernst H and Mohr U. Carcinogenicity studies on fibers, metal compounds and some other dusts in rats. Exp. Pathol. 1987;32:129-152. https://doi.org/10.1016/S0232-1513(87)80044-0
  35. Rittinghausen S, Ernst H, Muhle H and Morth U. Histopathological analysis of tumour types after intraperitoneal injection of mineral fibers in rats. In : Mechanisms in fiber carcinogenesis. eds. Brown RC, Hoskins JA, and Johnson NF. New York: Plenim Press. 1991;p.81-89.
  36. Sakai K, Hisanaga N, Kojima A and Takeuchi Y. Elemental composition of asbestos fibers recovered from human lung. Annual Report of Nagoya City Public Health Research Institute. 1991;37:116-119.
  37. Shasby DM, Petersen M, Hodous T, Boehlecks B and Merchant J. Respiratory morbidity of workers exposed to wollastonite through mining and milling. In Dusts and disease. eds. Lemen R and Dement JM. Park Forest South. IL : Pathtox. 1979;p.251-256.
  38. Simandl GJ, Paradis S, Orris GJ and Ray GE. Wollastonite. Skarns. In G. J. Simandl, Z. D. Hora, and D. V. Lefebure, eds. Selected British Columbia mineral deposit pro-files, vol. 3, Industrial minerals, British Columbia Ministry of Energy and Mines. Available electronically at http://www.em.gov.bc.ca/Mining/Geosurv/MetallicMinerals/MineralDepositProfiles/Profiles. 1999.
  39. Stanton MF and Wrench C. Mechanisms of mesothelioma induction with asbestos and fibrous glass. J. Natl. Cancer Inst. 1972;48:797-821.
  40. Stanton MF, Layard M, Tegeris A, Miller E, May M, Morgen E and Smith A. 1981. Relation of particle dimension to carcinogenicity in amphibole asbestos and other fibrous minerals. J. Natl. Cancer Inst. 1981;67:965-975.
  41. Tanaka I, Yamamoto H, Oyabu T, Ogami A. Biopersistence of manmade fibers by animal inhalation experiments in recent reports. Industrial Health, 2001;39:114-118. https://doi.org/10.2486/indhealth.39.114
  42. Tatrai E, Kovacikova Z, Brozik M and Six E. Pulmonary toxicity of wollastonite in vivo and in vitro. J. Appl. Toxicol. 2004;24:147-154. https://doi.org/10.1002/jat.965
  43. Victor L.R, Allen RG, Richard A, Andrew C, Helmut P, Philip C, Bryan C, Teri JF, Francoise GS, Jeff G, Phillip SH, Douglas WH, Koichi H. Pathology of asbestosis-an update of the diagnostic criteria, Report of the asbestosis committee of the college of american pathologists and pulmonary pathology society. Arch Pathol Lab Med. 2010;134:462-480.
  44. Virta R. "wollastonite" In U.S Geological Survey (U.S Bureau of Mines prior to 1996) Minerals Yearbook (annual). 2003.
  45. Warheit DB, Moore KA, Carakostas MC and Hartsky MA. Acute pulmonary effects of inhaled wollastonite fibers are dependent on fiber dimensions and aerosol concentrations. In eds. R. C. Brown, J. A. Hoskins, and N. F. Johnson, p143-156. Mechanisms in Fibre Carcinogenesis, Plenum Press, New York, 1991;143-156.
  46. Warheit DB, Hill LH, Brody AR. In Vitro effects of crocidolite asbestos and wollastonite on pulmonary macrophages and serum complement. Scan. Electron Microsc. 1984;ii:919-926.
  47. Warheit DB, Hartsky MA, HcHugh TA and Kellar KA. Biopersistence of inhaled organic and inorganic fibers in the lungs of rats. Environ. Health Perspect. 1994a;102(suppl. 5):151-157.
  48. Warheit DB, McHugh TA, Kellar KA and Hartsky MA. Biopersistence and pulmonary effects of inhaled p-aramid or wollastonite fibers following short-term exposures. In eds. D. L. Dungworth, J. L. Mauderly, and G. Oberclorster, Carcinogenic effects of solid particles in the respiratory tract. Washington, DC: ILSI Press. 1994b.