Ultrafine Particle Toxicities, Current Measurement Techniques and Controls

Ultrafine Particle의 독성, 측정방법 및 관리

  • Lee, Su-Gil (Discipline of Public Health, University of Adelaide) ;
  • Kim, Seong-Soo (Department of Environmental Administration, Catholic University of Pusan)
  • 이수길 (호주 애들래이드대학 공중위생학과) ;
  • 김성수 (부산가톨릭대학교 환경행정학과)
  • Received : 2010.03.02
  • Accepted : 2010.08.13
  • Published : 2010.09.30

Abstract

This study is an overview of toxicities and measurement techniques of ultrafine particles (UFPs), and their exposure controls. UFPs are ubiquitous in many working situations. Exposure to UFPs is possibly causing adverse health symptoms including cardio-respiratory disease to humans. In order to measure exposure levels of airborne UFPs, there are current available measurement guidelines, instruments and other techniques (i.e. contour mapping, control banding). However, these risk assessment techniques including measurement techniques, controls and guidelines are dependent on background levels, metrics (e.g. size, mass, number, surface area, composition), environmental conditions and controls. There are no standardized measurement methods available and no generic and specific occupational exposure standards for UFPs. It is thought that there needs to be more effort to develop Regulations and Exposure Standards for generic UFPs should be based on more exposure data, health surveys, toxicological data and epidemiological data. A carefully considered hierarchy of controls can also reduce the maximum amount of airborne UFPs being emitted from diverse sources in industries.

Keywords

References

  1. ACGIH, 2001, Industrial Ventilation: A manual of Recommended Practice. American Conference of Governmental Industrial Hygiesists. Ohio. USA.
  2. Andersson L, Bryngelsson IL, Ohlson CG, Naystrom P, Lilja BG, Westberg H. Quartz and dust exposure in Sweden iron foundries. J Occup Environ Hyg. 2009; 6: 9-18 https://doi.org/10.1080/15459620802649482
  3. Baveye P. Aggregation and toxicology of titanium dioxide nanoparticles. Environ Health Perspec. 2008; 116 (4): A 152
  4. Biswas S, Fine P, Geller MD, Hering SV, Sioutas C. Performance evaluation of a recently developed Water-Based Condensation Particle Counter. Aerosol Sci Technol. 2005; 39: 419-427 https://doi.org/10.1080/027868290953173
  5. Bowman A, Maibach HI. Percutaneous absorption of organic solvents. Int J Occup Environ Health. 2000; 6: 93-95 https://doi.org/10.1179/oeh.2000.6.2.93
  6. Bruske-Hohlfeld I, Peters A, Wichmann HE. 2004. Epidemiology of Nanoparticles. Compte-rendu du First International Symposiumon Occupational Health Implications of Nanomaterials. 12 to 14 October 2004. Buxton, Great-Britain. Health and Safety Laboratory(HSL). Oct 2004; 53-58
  7. Brouwer DH, Gijsbers JHJ, Lurvink MWM. Personal exposure to ultrafine particles in the workplace: Exploring sampling techniques and strategies. Ann Occup Hyg. 2004; 48(5): 439-453 https://doi.org/10.1093/annhyg/meh040
  8. Cheng YH, Chao YC, Wu CH, Tsai CJ, Uang SN, Shih TS. Measurements of ultrafine particl concentrations and size distribution in an iron foundry. J Hazardous Materials. 2008; 158: 124-130 https://doi.org/10.1016/j.jhazmat.2008.01.036
  9. Dennekamp M, Howarth S, Dick CA, Cherrie JW, Donaldson K, Seaton A. Ultrafine particles and nitrogen oxides generated by gas and electric cooking. Occup Environ Med. 2001; 58: 511-516 https://doi.org/10.1136/oem.58.8.511
  10. Donaldson K. 2004. The Toxicology of Airborne Nanoparticles. Proceedings of the First International Symposium on Occupational Health Implications of Nanomaterials. Health and Safety Laboratory (HSL). October 2004; 12-14
  11. Evans DE, Heitbrink WA, Slavin TJ, Peters TM. Ultrafine and respirable particles in an automotive grey iron foundry. Ann Occup Hyg. 2008; 52(1): 9-21
  12. Elihn K, Berg P. Ultrafine particle characteristics in seven industrial plants. Ann Occup Hyg. 2009; 53(5): 475-484. https://doi.org/10.1093/annhyg/mep033
  13. Faux SP, Tran CL, Miller BG, Jones AD, Monteiller C, Donaldson K. In vitro Determinants of Particulate Toxicity: The Dose Metric for Poorly Soluble Dusts. HSE Research Report. 2003; 154
  14. Ferin JGO, Penney DP. Pulmonary retention of ultrafine and fine particles in Rats. American Journal of Respiratory Cell and Molecular Biology. 1992; 6: 535-542 https://doi.org/10.1165/ajrcmb/6.5.535
  15. Gaggeler HW, Baltensperger U, Emmenegger M, Jost DT, Schmidt-Ott A, Haller P, Hofmann M. The epiphaniometer, a new device for continuous aerosol monitoring. J Aerosol Sci. 1989; 20: 557-564 https://doi.org/10.1016/0021-8502(89)90101-8
  16. Harford A., Edwards J, Priestly B, Wright P. Current OHS best practices for the Australian Nanotechnology Industry: A position paper by the NanoSafe Australia Network. Journal of Occupational Health and Safety-Aust NZ. 2007; 23(4): 315-331
  17. He C, Morawska L, Taplin L. Particle emission characteristics of office printers. Environ Sci Technol. 2007; 41: 6039-6045 https://doi.org/10.1021/es063049z
  18. Heitbrink WA, Evans DE, Peters TM, Slavin TJ. The characterization and mapping of very fine particles in an engine machining and assembly facility. J Occup Environ Hyg. 2007; 4:341-351 https://doi.org/10.1080/15459620701290081
  19. Heitbrink WA, Evans DE, Ku BK, Maynard AD, Slavin TJ, Peters TM. Relationships among particle number, surface area, and respirable mass concentrations in automotive engiene manufacturing. J Occup Environ Hyg. 2009; 6: 19-31
  20. Hering SV, Stolzenburg MR, Quant FR, Oberreit DR, Keady PB. A laminar-flow, Water-based Condensation Particle Counter (WCPC). Aerosol Sci Technol. 2005; 39: 659-672 https://doi.org/10.1080/02786820500182123
  21. Hillamo R, Makela T, Kerminen VM. Electrical Low Pressure Impactor(ELPI) in Atmospheric Aerosol Studies. Finnish Meteorological Institute. Helsinki Finland. 2002
  22. HSE. 2004a. Nanoparticles: An Occupational Hygiene Review. London: Health and Safety Executive (HSE). UK. URL: www.hse.gov.au/resaerch/rrhtm/rr274.htm
  23. HSE. 2004b. Primary regulator of health and safety in British industry; Royal Society / Royal Academy of Engineering report 'Nanoscienceandnanotechnologies'. Health and Safety Executive (HSE). UK. URL: www.nanotec.org.uk/final report.htm
  24. HSE. 2005. Control of Substances Hazardous to Health. 5th edition. Approved Code of Practice and Guidance(L5). HSE Books. ISBN 9780717629817
  25. HSL. 2005. Nanomaterials-A risk to health at work? Proceedings of the First International Symposium on Occupational Health Implications of Nanomaterials. 12-14 October 2004. Health and Safety Laboratory(HSL). Edited by the Health and Safety Executive(HSE) in the UK and the US National Institute for Occupational Safety and Health(NIOSH).
  26. International Commission on Radiological Protection. 1994. Human Respiratory Tract Model for Radiological Protection. International Commission on Radiological Protection Publication66${\ast}{\ast}$. Oxford. Pergamon: Elsevier Science Ltd.
  27. International Organization for Standardization. 2007. Workplace Atmospheres-Ultrafine, Nanoparticles and Nono-structured Aerosols-Inhalation Exposure Characterization and Assessment. Technical Report. International Organization for Standardization(ISO/TR 27628: 2007(E)), Switzerland.
  28. Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, Wulf CH. Systemic absorption of the sunscreens benzophenone-3, octyl-Methoxycinnamate, and 3-(4-Methyl-Benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. Journal of Investigative Dermatology. 2004; 123: 57-61 https://doi.org/10.1111/j.0022-202X.2004.22725.x
  29. Jortner J. Rao CNR. Nanostructured advanced materials; Perspectives and directions. Pure and Applied Chemistry. 2002; 74: 1491-1506 https://doi.org/10.1351/pac200274091491
  30. Kaur A, Clark RDR, Walsh PT, Arnold SJ, Colvile RN. Nieuwenhuijsen MJ. Exposure visualization of ultrafine particle counts in a transport microenvironment. Atmos Environ. 2006; 40: 386-398 https://doi.org/10.1016/j.atmosenv.2005.09.047
  31. Konstandopoulos AG, Zarvalis D, Papaioannou E, Vlachos ND, Boretto G, Pidria MF, Faraldi P, Piacenza O, Prenninger P, Cartus T, Schreier H, Brandstatter W, Wassermayr C, Lepperhof G, Scholz V, Luers B, Schnitzler J, Claussen M, Wollmann A, Maly M, Tsotridis G, Vaglieco BM, Merola SS, Webster D, Bergeal D, Gorsmann C, Oberdorster H, Fino D, Russo N, Saracco G, Specchia V, Moral N, D'anna A, D'alessio A, Zahoransky R, Laile E, Schmidt S, Ranalli M. 2004. The diesel exhaust aftertreatment(DEXA) cluster, a systematic approach to diesel particulate emission control in Europe. SAE Tech Paper No 2004-01-0694(SP-1861).
  32. Lademann J, Weigmann H, Rickmeyer C, Barthelmes H, Schaefer H, Mueller G, Sterry W. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Applied Skin Physiology. 1999; 12: 247-256 https://doi.org/10.1159/000066249
  33. Lee K, Mukund R. Filter Collection in 'Aerosol measurement and principles, techniques and applications', New York: John Wiley & Sons. 2001. p.197-228
  34. Lee S, Obendorf SK. Statistical model of pesticides penetration through woven work clothing fabrics. ArchEnvironContamToxicol.2005; 49: 266-273 https://doi.org/10.1007/s00244-004-0127-8
  35. Lee SG, Lee NW. A development on assessment method of PVC gloves used in pest control program. J Korean Society of Safety. 2006; 21(3): 53-58
  36. Lee MH, McClellan WJ, Cnadela J, Andrews D, Biswas P. Reduction of nanoparticle exposure to welding aerosols by modification of the ventilation system in a workplace. J Nanoparticle Research 2007; 9: 127-136.
  37. Lee S, Liu X, Deemer A, Sanderson B, Pisaniello D. 2009a. Ultrafine Particle Emissions and Exposure Measurements in South Australian Workplaces-A Pilot Study. AIOH 27thAnnual Conference .5-9 December 2009 .Canberra. ACT. Australia.
  38. Lee SG, Pisaniello D, Tkaczuk M, Edwards J. Chemical gloves performance: A case study on malathion use in Mediterranean fruit fly control. J Occup Health Safety-Aust NZ. 2009b; 25(2): 129-135.
  39. Lida K, Stolzenburg MR, McMurry P, Smith JN, Quant FR, Oberreit DR, Keady PB, Eiguren-Fernandez A, Lewis GS, Kreisberg NM, Hering SV. An ultrafine, Water-Based Condensation Particle Counter and its evaluation under field conditions. Aerosol Sci Technol. 2008; 42: 862-871 https://doi.org/10.1080/02786820802339579
  40. Lison D, Lardot C, Huaux F, Zanetti G, Fubini B. Influenece of particle surface area on the toxicity of insoluble manganese dioxide dust. Archieves of Toxicology. 1997; 71(12): 725-729 https://doi.org/10.1007/s002040050453
  41. Liu X, Lee S, Pisaniello D, Jankewicz G, Sanderson B. 2009. Measurement of Fine and Ultrafine Particle Exposure in an Iron Foundry in South Australia. AIOH 27th Annual Conference. 5-9 December 2009. Canberra. ACT. Australia.
  42. Long T, Saleh N, Tilton R, Lowry GV, Veronesi B. Titanium dioxide (P25) produces oxidative stress in immortalized brain microglia (BV2): Implication of nanoparticle neurotoxicity. Environ Sci Technol. 2006; 40 (14): 4346-4352 https://doi.org/10.1021/es060589n
  43. Mark D, 2004. Control of Nanoparticles, Proceedings of the First International Symposium on Occupational Health Implications of Nanomaterials. 12-14 October 2004. Health and Safety Laboratory (HSL).
  44. Matson U, Ekberg LE, Afshari A. Measurement of ultrafine particles, A comparison of two handheld condensation particle counters. Aerosol Science and Technology. 2004; 38: 487-495 https://doi.org/10.1080/02786820490462200
  45. Mavon A, Miquel C, Lejeune O, Payre B, Moretto P. In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacol Physiol. 2007; 20(1): 10-20 https://doi.org/10.1159/000096167
  46. Maynard AD. Experimental determination of ultrafine TiO2 de-agglomeration in surrogate pulmonary surfactant - preliminary results. Ann Occup Hyg. 2002; 46: 197-202 https://doi.org/10.1093/annhyg/mef035
  47. Maynard AD, Kuempel ED. Airborne nanostructured particles and occupational health. J Nanoparticle Res. 2005; 7(28): 587-614 https://doi.org/10.1007/s11051-005-6770-9
  48. Morawska L, Moore MR, Ristovski Z. 2004. Health Impacts on Ultrafine Particles. Environment Standards Branch. Department of the Environment and Heritage. Commonwealth of Australia. Canberra. ACT. Australia. ISBN 0642550557.
  49. Morawska L, Wang H, Ristovski Z, Jayaratne ER, Cheung HC, Ling X, He C. JEM Spotlight: Environmental monitoring of airborne nanoparticles. J Environ Moni. 2009; 11: 1758-1773 https://doi.org/10.1039/b912589m
  50. Mordas G, Manninen HE, Petaja T, Aalto PP, Hameri K, Kulmala M. On Operation of the Ultra-Fine Water-Based CPC TSI 3786 and comparison with other TSI Models (TSI 3776, TSI 3772, TSI 3025, TSI 3010, TSI 3007). Aerosol Sci Technol. 2008; 42: 152-158 https://doi.org/10.1080/02786820701846252
  51. Nanoforum. 2004. The European strategy for nanotechnology, The Commission Communication ' Towards a European Strategy for nanotechnology' . URL: www.cordis.lu/nanotechnology/src/communication/htm
  52. Ness S A. 1994. Surface and Dermal Monitoring for Toxic Exposures. NewYork, Van Nostrand Reinhold. An Internatonal TYhomson Publishing Company
  53. NOHSC. 1997. Predictive Exposure Modelling: Assessment of Respiratory and Dermal Exposures to Ethyl Parathion and Methyl Parathion in Airblast Application in Orchards. National Occupational Health and Safety Commission. Worksafe Australia, AGPS Canberra. URL: www.apvma.gov.au/chemrev/downloads/parathionmethyl_ohs.pdf
  54. NIOSH. 2006. Approaches to Safe Nanotechnology: An Information Exchange with NIOSH. National Institute for Occupational Safety and Health. Centres for Disease Control and Prevention, Department of Health and Human Services.
  55. NIOSH. 2008a. NIOSH Nanotechnology Field Research Effort, National Institute for Occupational Safety and Health. URL:www.cdc.gov/niosh/docs/2008-121/
  56. NIOSH. 2009. Approaches to Safe Nanotechnology; Managing the Health and Safety Concerns Associated with Engineered Nanomaterials. Department of Health and Human Services. National Institute for Occupational Safety and Health. DHHS(NIOSH) Publication No. 2009-125.
  57. Oberdorster G, Ferin R, Gelein J, Soderholm SC, Finkelstein J. Role of the alveolar macrophage in lung injury-studies with ultrafine particles. Environ Health Perspect. 1992; 97: 193-199 https://doi.org/10.1289/ehp.9297193
  58. Oberdorster G, Ferin J, Lehnert BE. Correlation Between Particle-Size, in-vivo Particle Persistence, and Lung Injury. Environmental Health Perspectives. 1994; 102(S5): 173-179 https://doi.org/10.1289/ehp.94102s10173
  59. Oberdorster G. 2000. Toxicology of ultrafine particles: in vivo studies. Phil Trans Roy Soc London. Series A 358: 2719-2740 https://doi.org/10.1098/rsta.2000.0680
  60. Oberdorster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder ACP. 2000. Acute Pulmonary Effects of Ultrafine Particles in Rats and Mice. Health Effects Institute Report #96.
  61. Oberdorster G. Pulmonary Effects of inhaled ultrafine particles. International Archieves of Occupational and Environmental Health. 2001; 74 (1): 1-8.
  62. Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts, A, Kreyling W, Cox C. Extrapulmonary translocation of ultrafine carbon particles following whole body inhalation exposure of rats. Journal of Toxicology and Environmental Health A. 2002; 65(20): 1531-1543 https://doi.org/10.1080/00984100290071658
  63. Oberdorster G. 2004a. Inhaled Nano-sized Particles: Potential Effects and Mechanisms. Proceedings of the First International Symposium on Occupational Health Implications of Nanomaterials. 12-14 October 2004. Health and Safety Laboratory (HSL).
  64. Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. Translocation of inhaled ultrafine particles to the brain. Inhalation Toxicology. 2004b; 16: 437-445. https://doi.org/10.1080/08958370490439597
  65. Ostiguy C, lapointe G, Menard L. 2008. Health Effects of Nanoparticles. Report R-589. Second Edition, IRRST-Communication Division. Quebec. Canada. URL:www.irsst.qc.ca
  66. Paik SY, Zalk DM, Swuste P. Application of a pilot control banding tool for risl level assessment and control of nanoparticle exposures. Ann Occup Hyg. 2008; 52 (6): 419-428 https://doi.org/10.1093/annhyg/men041
  67. Peters G. 2004. Risk Evaluation & Control: Current Perspective. Proceedings of the First International Symposium on Occupational Health Implications of Nanomaterials. 12-14 October 2004. Health and Safety Laboratory (HSL).
  68. Peters TM, Heitbrink WA, Evans DE, Slavin TJ, Maynard AD. The mapping of fine and ultrafine particle concentrations in an engine machining and assembly facility. Am Occup Hyg. 2006; 50(3): 249-257
  69. Peters TM, Elzey S, Johnson R, Park H, Grassian VH, Maher T, O'Shaughnessy P. Airborne monitoring to distinguish engineered nanomaterials from incidental particles for environmental health and safety. J Occup Environ Hyg. 2009; 6: 73-81 https://doi.org/10.1080/15459620903249695
  70. PHED. 1992. Pesticide Handlers Exposure Database. version 1.1. U.S. EPA. Health and Welfare Canada, National Agricultural Chemicals Association. Versar Inc. Springfield.
  71. Poet TS, McDougal JN. 2002. Skin absorption and human risk assessment. Chemico-Biological Interactions 140: 19-34. https://doi.org/10.1016/S0009-2797(02)00013-3
  72. Ramachandran G, Paulsen D, Watts W, Kittelson D. Mass, surface area and number metrics in diesel occupational exposure assessment. J Environ Monit. 2005; 7: 728-735 https://doi.org/10.1039/b503854e
  73. Ryman-Rasmussen JP, Riviere JE, Monterio-Riviere NA. Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes. J Invest Dermatol. 2007; 127: 143-153 https://doi.org/10.1038/sj.jid.5700508
  74. Seaton A, MacNee W, Donaldson K, Godden D. Particulate air pollution and acute health effects. Lancet. 1995; 345: 176-78. https://doi.org/10.1016/S0140-6736(95)90173-6
  75. Seipenbusch M, Binder A, Kasper G, Temporal evolution of nanoparticle aerosols in workplace exposure. Ann Occup Hyg. 2008; 52(8): 707-716 https://doi.org/10.1093/annhyg/men067
  76. Sen D, Wolfson H, Dilworth M. Lead exposure in scaffolders during refurbishment construction activity-an observational study. Occupational Medicine. 2002; 52: 49-54 https://doi.org/10.1093/occmed/52.1.49
  77. Suwa T, Hogg JC, Quinlan KB, Ohgami A, Vincent R, van Eeden SF. Particulate air pollution induces progression of atherosclerosis. Am Coll Cardiol. 2002; 39: 943-945 https://doi.org/10.1016/S0735-1097(02)01709-6
  78. Tammet H, Mirme A, Tamm E. Electrical aerosol spectrometer of Tartu University. Atmos Res. 2002; 62: 315-324 https://doi.org/10.1016/S0169-8095(02)00017-0
  79. Thorpe A. Assessment of personal direct-reading dust monitors for the measurements of airborne inhalable dust. Ann Occup Hyg. 2007; 51(1): 97-112
  80. Tickner J, Friar J, Creely KS, Cherrie JW, Pryde DE, Kingston J. The development of the EASE model. Ann Occup Hyg. 2005; 49 (2): 103-110 https://doi.org/10.1093/annhyg/meh085
  81. Tinkle SS, Antonini JM, Rich BA, Robert JR, Salmen R, DePree K, Adkin EJ. Skin as a route of exposure and sensitization in chronic beryllium disease. Environ Health Perspect. 2003; 111(9): 1202-1208 https://doi.org/10.1289/ehp.5999
  82. Tran CL, Buchanan D, Cullen RT, Searl A, Jones AD, Donaldson K. Inhalation of poorly soluble particles II. Influence of particle surface area on inflammation and clearance. Inhalation Toxicology. 2000; 12: 1113-1126 https://doi.org/10.1080/08958370050166796
  83. Van-Wendel-De-Joode B, Brouwer DH, Vermeulen R, Van Hemmen JJ, Heederik D, Kromhout H. DREAM; A method for semi-quantitative dermal exposure assessment. Ann Occup Hyg. 2003; 47 (1): 71-87 https://doi.org/10.1093/annhyg/meg012
  84. Vermeulen R, Stewart P, Kromhout H. Dermal exposure assessment in occupational epidemiologic research. Scand J Work Environ Health. 2002; 28:371-385 https://doi.org/10.5271/sjweh.689
  85. Zalk DM, Paik SY, Swuste P. Evaluating the control banding nanotool: a qualitative risk assessment method for controlling nanoparticle exposures. J Nanopart Res. 2009; 11: 1685-1704. https://doi.org/10.1007/s11051-009-9678-y
  86. Zhao Y, Hu M, Slanina S, Zhang Y. Chemical compositions of fine partiuculate organic matter emitted from chinese cooking. Environ Sci technol. 2007; 41: 99-105 https://doi.org/10.1021/es0614518
  87. Zimmer AT, Maynard A.D. Investigation of the aerosols produced by a high-speed, hand-held grinder using various substrates. Annals of Occupational Hygiene. 2002; 46(8): 663-672 https://doi.org/10.1093/annhyg/mef089