한국산업보건학회지 (Journal of Korean Society of Occupational and Environmental Hygiene)

  • 제20권2호
  • /
  • Pages.119-130
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  • 2010
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  • 2384-132X(pISSN)
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  • 2289-0564(eISSN)
한국산업보건학회 (Korean Industrial Hygiene Association)
권호 표지

랫드의 기도로 투여된 투각섬석함유활석이 호흡기계에 미치는 영향 연구

Toxicity of Talc Containing Tremolite asbestos on Respiratory System in Sprague-Dawely Rats

  • 정용현 (산업안전보건연구원 화학물질안전보건센터) ;
  • 한정희 (산업안전보건연구원 화학물질안전보건센터) ;
  • 강민구 (산업안전보건연구원 화학물질안전보건센터) ;
  • 이성배 (산업안전보건연구원 화학물질안전보건센터) ;
  • 김종규 (산업안전보건연구원 화학물질안전보건센터) ;
  • 김현영 (산업안전보건연구원 화학물질안전보건센터) ;
  • 양정선 (산업안전보건연구원 화학물질안전보건센터)
  • Chung, Yong-Hyun (Chemical Safety and Health Research Center, Occupational Safety & Health) ;
  • Han, Jeong-Hee (Chemical Safety and Health Research Center, Occupational Safety & Health) ;
  • Kang, Min-Gu (Chemical Safety and Health Research Center, Occupational Safety & Health) ;
  • Lee, Sung-Bae (Chemical Safety and Health Research Center, Occupational Safety & Health) ;
  • Kim, Jong-Kyu (Chemical Safety and Health Research Center, Occupational Safety & Health) ;
  • Kim, Hyeon-Yeong (Chemical Safety and Health Research Center, Occupational Safety & Health) ;
  • Yang, Jung-Sun (Chemical Safety and Health Research Center, Occupational Safety & Health)
  • 투고 : 2010.04.07
  • 심사 : 2010.06.01
  • 발행 : 2010.06.30
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초록

Pulmonary toxicity of talc containing tremolite asbestos (TCT) has been studied in term sequential in Sprague-Dawely rats. UICC chrysotile(average diameter 0.03${\mu}m$, average length 2.93${\mu}m$) was applied as the positive control. TCT was analyzed for its physicochemical properties by transmission electron microscope equipped with energy dispersive X-ray spectrometer(TEM-EDS). The effects of 2mg TCT(talc average diameter 9.7${\pm}$8.4${\mu}m$; tremolite average diameter 1.6${\pm}$1.6${\mu}m$, average length 10.8${\pm}$7.0${\mu}m$) on pathological changes were evaluated after 1, 8 weeks instilled into rat lungs. 2mg Chrysotile continuously affected lung pathological changes. Inflammation and granuloma response broke out from 1 week after instilled with chrysotile and the pathological examination further showed increased legions of lung after 8 weeks. But TCT did not showed lung pathological changes. The biopersistence of TCT and chrysotile was evaluated by TEM- EDS. Whereas chrysotile continuously have retained to 8 weeks instilled into rat lungs, talc of TCT showed statistically significant decrease of diameter from 1 weeks and statistically significant change in Si atomic % compositions at 8 weeks instilled into rat lungs. Physicochemical properties of tremolite of TCT were not affected until 8 weeks instilled into rat lungs. This study showed that the durability of TCT in the lungs is much weaker than chrysotile.

키워드

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