Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Airborne Nicotine Concentrations in Harvesting and the Processing of Tobacco Leaves

담뱃잎 수확 및 가공 과정에서 공기 중 니코틴농도

  • Park, Sung-Jun (Department of Preventive Medicine, Dongguk University College of Medicine) ;
  • Kim, Jong-Seuk (Department of Preventive Medicine, Dongguk University College of Medicine) ;
  • Kim, Jik-Su (Jinbo Tobacco Growers Cooperative Association) ;
  • Lee, Kwan (Department of Preventive Medicine, Dongguk University College of Medicine) ;
  • Lim, Hyun-Sul (Department of Preventive Medicine, Dongguk University College of Medicine)
  • 박성준 (동국대학교 의과대학 예방의학교실) ;
  • 김종석 (동국대학교 의과대학 예방의학교실) ;
  • 김직수 (진보엽연초생산협동조합) ;
  • 이관 (동국대학교 의과대학 예방의학교실) ;
  • 임현술 (동국대학교 의과대학 예방의학교실)
  • Received : 2009.11.09
  • Accepted : 2010.03.15
  • Published : 2010.03.30
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Abstract

Green tobacco sickness (GTS) is known as an occupational disease among tobacco harvesters, and a form of acute nicotine intoxication by the absorption of nicotine through the skin from the wet green tobacco plant. On the assumption that GTS may occur by inhalation as well as absorption of nicotine, we measured the airborne nicotine concentration in tobacco field and the processing room of tobacco leaves. We measured the airborne nicotine concentrations in the tobacco field and processing room between 13 and 30 July 2008. All sampling and analyses of airborne nicotine were conducted according to the manual of analytic methods of NIOSH 2551, and we sampled 2 times at 11 points in the tobacco field by area sampling. The sampling in the processing room of tobacco leaves was conducted at 3 points, and earlymorning dew was collected from the tobacco by wringing the moisture into specimen bottles. The airborne nicotine concentration [geometric mean (geometric standard deviation)] in the tobacco field in the P.M. was higher [49.2 mg/$m^3$ (1.3)] than the A.M. concentration [43.4 mg/$m^3$ (1.4)]. Similarly, the nicotine concentration in the processing room of tobacco leaves was 224.4 mg/$m^3$ (1.2), and the concentration of nicotine in the dew was 64.7 mg/${\ell}$ (1.7). Based on our results, the airborne nicotine concentration in the tobacco field and the processing room of tobacco leaves were 100 and 400 times higher than the occupational recommended values (TLV-TWA of 0.5 mg/$m^3$), respectively. In the future, it is hoped that epidemiologic studies and environmental measurements will be conducted for GTS which occurs by inhalation of nicotine. If GTS is confirmed to occur by inhalation of nicotine, respiratory and dermal protective equipment must be distributed.

Keywords

References

  1. 김효철, 백남원, 이경숙, 김경란, 김원. 공기중 니코틴포집에 있어 국산 확산포집기와 능동포집기의 비교평가. 한국환경보건학회지 2006;32(5):485-491
  2. 박용선, 노영만, 김치년. PC방에서의 간접흡연에 따른 요중 코티닌의 농도. 한국환경위생학회지 2002;28(1): 11-20
  3. 엽연초생산협동조합중앙회. 2009년 잎담배 계약현황 [cited 2010 Jan 7.]. Available from; URL: http://yyc.nonghyupi.com/
  4. 이관, 임현술. 2003년 일부 담배 재배농에서 담뱃잎 농부병의 유병률 및 위험요인. 한국역학회지 2005;27(1):129-139
  5. 이관, 임현술, 김헌, 남시현. 담뱃잎농부병 환자의 요중 코티닌 농도. 대한산업의학회지 2004;16(4):413-421
  6. 이주섭, 배성한, 임현술, 이관. 담배 재배농에서 담뱃잎농부병의 유병률 변화와 역학적 특성. 한국역학회지 2004;26(1):39-49
  7. 임현술, 이관. 담배 재배 농부에서 발생한 담뱃잎농부병(green tobacco sickness) 증례. 한국농촌의학회지 2001;26(2):7-14
  8. 임현술, 이관. 일부 담배 재배농의 담뱃잎농부병 실태. 한국역학회지 2002;24(1):29-36
  9. 임현술, 이관, 남시현. 일부 담배 재배농에서 담뱃잎농부병의 유병률 및 위험요인. 예방의학회지 2004;37(1):37-43
  10. 장준혁, 임현술, 이관, 이주섭. 건조기를 통하여 발생이 추정되는 담뱃잎농부병(Green Tobacco Sickness) 3례. 동국의학 2003;10(1):129-138
  11. 전매청 한국전매사. 서울: 고려서적주식회사; 1980.(27-23쪽)
  12. 최인자, 이윤근, 김원, 우지훈, 선옥남 등. 담뱃잎 재배농의 니코틴 노출평가. 한국산업위생학회 2008년도 동계학술대회 발표자료집 2008(p116-118쪽)
  13. 하권철, 백남원, 박동욱, 윤충식, 김원 등. 실내사무환경의 환경성담배연기(ETS)의 지표물질에 관한 연구. 한국산업위생학회지 2003;13(2): 152-159
  14. 황규석, 백남원, 하권철. 서울시내 PC방에서의 환경성담배연기(ETS) 농도에 관한 연구. 한국환경위생학회지 2003;29(3):33-49
  15. ACGIH. Nicotine; Documentation of the threshold limit values and biological exposure indices. 2008.
  16. Arcury TA. Quandt SA. Preisser JS. Bemert JT, Norton D et al. High levels of transdermal nicotine exposure produce green tobacco sickness in Latino farmworkers. Nicotine Tob Res 2003;5(3):315-321 https://doi.org/10.1080/1462220031000094132
  17. Ballard T, Ehlers J, Freund E, Auslander M, Brandt V, et al. Green tobacco sickness: occupational nicotine poisoning in tobacco workers. Arch Environ Health 1995:50(5):384-389 https://doi.org/10.1080/00039896.1995.9935972
  18. Boylan BB, Brandt V, Muehlbauer J, Auslander M, Spurlock C el al. Green tobacco sickness in tobacco harvesters-Kentucky, 1992. MMWR 1993;42:237-240
  19. D'Alessandro A, Benowitz NL, Muzi G, Eisner MD, Filiberto S et al. Systemic nicotine exposure in tobacco harvesters. Arch Environ Health 2001;56(3):257-263 https://doi.org/10.1080/00039890109604451
  20. Doctor PB, Gokani VN, Kulkami PK, Parikh JR, Saiyed HN. Determination of nicotine and cotinine in tobacco harvesters' urine by solid-phase extraction and liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 2004;802(2):323-328 https://doi.org/10.1016/j.jchromb.2003.12.013
  21. Ellenhom MJ. Schonwald S, Ordog G, Wasserberger J. Natural toxins. In; Ellenhorn MJ (eds.) Ellenhorn' s Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Baltimore: Williams and Wilkins: 1997.
  22. Ellingsen DG, Fladseth G, Daae HL, Gjolstad M, Kjaerheim K et al. Airborne exposure and biological monitoring of bar and restaurant workers before and after the introduction of a smoking ban. J Environ Monit 2006;8(3):362-368 https://doi.org/10.1039/b600050a
  23. Gehlbach SH, Perry LD, Williams WA, Freeman JI. Nicotine absorption by workers harvesting green tobacco. Lancet 1975;1(7905):478-480
  24. Ghosh SK, Parikh JR, Gokani VN, Kashyap SK, Chatteejee SK. Studies on occupational health problems during agricultural operation of Indian tobacco workers: a preliminary survey report. J Occup Med 1979;21(1):45-47
  25. Ghosh SK, Gokani VN, Doctor PB, Parikh JR. Intervention studies against "green symptoms" among Indian tobacco harvesters. Arch Environ Health 1991;46(5):316-317 https://doi.org/10.1080/00039896.1991.9934396
  26. Gorini G, Gaspanini A, Fondelli MC, Costantini AS, Centrich F et al. Environmental tobacco smoke (ETS) exposure in Florence hospitality venues before and after the smoking ban in Italy. J Occup Environ Med 2005:47: 1208-1209
  27. Higgins J, Ewing PL, McGuigan HA. The effect of evaporation and radiation on nicotine solutions. J Pharmacol Exp Ther 1931;42(2):213-216
  28. National Institute for Occupational Safety and Health. HHE Report No. HETA-92-403-2329, Kentucky Cabinet for Human Resources. Kentucky: NIOSH; 1992.
  29. National Institute for Occupational Safety and Health(NIOSH). Manual of Analytical Methods. 4th. ed. US. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, NIOSH; 1998.
  30. Onuki M, Yokoyama K, Kimura K, Sato H, Nordin RB et al. Assessment of urinary cotinine as a marker of nicotine absorption from tobacco leaves: A study on tobacco farmers in Malaysia. J Occup Health 2003;45(3); 140-145 https://doi.org/10.1539/joh.45.140
  31. Pappano AJ. Cholinoceptor-Activating & Cholinesterase-inhibiting drugs. In: Katzung BG eds. Basic & Clinical pharmacology. New York: McGraw-Hill;2001.
  32. Stillman F, Navas-Acien A, Ma J, Ma S, Avila-Tang E et al. Second-hand tobacco smoke in public places in urban and rural China. Tob Control 2007;16(4):229-234 https://doi.org/10.1136/tc.2006.018333
  33. Swinker M, Meredith JT. A seizure in the tobacco field. Green tobacco sickness. N C Med J 2000;61(1):390-392