Anatomy and Cell Biology

  • 제43권3호
  • /
  • Pages.241-251
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  • 2010
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  • 2093-3665(pISSN)
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  • 2093-3673(eISSN)
대한해부학회 (Korean Association of Anatomists)
권호 표지
DOI QR코드

DOI QR Code

Migratory defect of mesencephalic dopaminergic neurons in developing reeler mice

  • Kang, Woo-Young (Department of Anatomy, School of Medicine, Ajou University) ;
  • Kim, Sung-Soo (Department of Anatomy, School of Medicine, Ajou University) ;
  • Cho, Sung-Kuk (Department of Anatomy, School of Medicine, Ajou University) ;
  • Kim, So-Yeon (Department of Anatomy, School of Medicine, Ajou University) ;
  • SuhKim, Hae-Young (Department of Anatomy, School of Medicine, Ajou University) ;
  • Lee, Young-Don (Department of Anatomy, School of Medicine, Ajou University)
  • 투고 : 2010.07.31
  • 심사 : 2010.09.14
  • 발행 : 2010.09.30
⟨ 이전 논문 다음 논문 ⟩

초록

Reelin, an extracellular glycoprotein has an important role in the proper migration and positioning of neurons during brain development. Lack of reelin causes not only disorganized lamination of the cerebral and cerebellar cortex but also malpositioning of mesencephalic dopaminergic (mDA) neurons. However, the accurate role of reelin in the migration and positioning of mDA neurons is not fully elucidated. In this study, reelin-deficient reeler mice exhibited a significant loss of mDA neurons in the substantia nigra pars compacta (SNc) and a severe alteration of cell distribution in the retrorubal field (RRF). This abnormality was also found in Dab1-deficinet, yotari mice. Stereological analysis revealed that total number of mDA neurons was not changed compared to wild type, suggesting that the loss of mDA neurons in reeler may not be due to the neurogenesis of mDA neurons. We also found that formation of PSA-NCAM-positive tangential nerve fibers rather than radial glial fibers was greatly reduced in the early developmental stage (E14.5) of reeler. These findings provide direct evidence that the alteration in distribution pattern of mDA neurons in the reeler mesencephalon mainly results from the defect of the lateral migration using tangential fibers as a scaffold.

키워드

과제정보

연구 과제번호 : GRRC project

연구 과제 주관 기관 : Gyeonggi Provincial Government

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