한국의학물리학회지:의학물리 (Progress in Medical Physics)

  • 제21권2호
  • /
  • Pages.145-152
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  • 2010
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  • 2508-4445(pISSN)
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  • 2508-4453(eISSN)
한국의학물리학회 (Korean Society of Medical Physics)
권호 표지

소동물 영상을 위한 Siemens Inveon PET 스캐너의 성능평가

Performance Measurement of Siemens Inveon PET Scanner for Small Animal Imaging

  • 유아람 (한국원자력의학원 방사선의학연구소 분자영상연구부) ;
  • 김진수 (한국원자력의학원 방사선의학연구소 분자영상연구부) ;
  • 김경민 (한국원자력의학원 방사선의학연구소 분자영상연구부) ;
  • 이영섭 (한국원자력의학원 방사선의학연구소 분자영상연구부) ;
  • 김종국 (한국원자력의학원 방사선의학연구소 분자영상연구부) ;
  • 우상근 (한국원자력의학원 방사선의학연구소 분자영상연구부) ;
  • 박지애 (한국원자력의학원 방사선의학연구소 분자영상연구부) ;
  • 김희중 (연세대학교 보건과학대학 방사선학과) ;
  • 천기정 (한국원자력의학원 방사선의학연구소 분자영상연구부)
  • Yu, A-Ram (Molecular Imaging Research Center, Korea Institute Radiological and Medical Science) ;
  • Kim, Jin-Su (Molecular Imaging Research Center, Korea Institute Radiological and Medical Science) ;
  • Kim, Kyeong-Min (Molecular Imaging Research Center, Korea Institute Radiological and Medical Science) ;
  • Lee, Young-Sub (Molecular Imaging Research Center, Korea Institute Radiological and Medical Science) ;
  • Kim, Jong-Guk (Molecular Imaging Research Center, Korea Institute Radiological and Medical Science) ;
  • Woo, Sang-Keun (Molecular Imaging Research Center, Korea Institute Radiological and Medical Science) ;
  • Park, Ji-Ae (Molecular Imaging Research Center, Korea Institute Radiological and Medical Science) ;
  • Kim, Hee-Joung (Department of Radiological Science, College of Health Science, Yonsei University) ;
  • Cheon, Gi-Jeong (Molecular Imaging Research Center, Korea Institute Radiological and Medical Science)
  • 투고 : 2010.02.18
  • 심사 : 2010.05.10
  • 발행 : 2010.06.30
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초록

Inveon PET은 최근에 출시된 소동물 전용 PET 시스템이다. 이 연구에서는 Inveon PET 스캐너의 성능을 평가하기 위하여 공간 분해능, 민감도, 산란분획, 잡음등가계수(Noise equivalent count rate: NECR)를 측정하였다. 공간 분해능 측정은 에너지창 350~625 keV, 민감도, 산란분획, NECR 측정은 350~750 keV에서 수행하였고 동시계수창은 3.432 ns였다. 크기 $1\;mm^3$의 F-18 점 선원을 만들어 중심에서부터 5 cm 벗어난 위치까지 공간 분해능을 측정하였다. 민감도를 측정하기 위하여 스캐너의 축방향 길이와 동일한 길이 12.7 cm의 F-18 선 선원을 만들고 두께 2 mm의 알루미늄 관을 1개에서 5개까지 차례로 씌우며 절대 민감도를 계산하였다. 산란분획과 NECR 측정하기 위하여 두 가지 NEMA 산란 팬텀(랫(rat): 지름 50 mm, 길이 150 mm/마우스(mouse): 지름 25 mm, 길이 70 mm)을 이용하였고, F-18 선 선원(랫: 353 MBq, 마우스: 201 MBq)를 만들어 14반감기(25.6시간) 동안 데이터를 획득하였다. F-18의 중심에서 공간 분해능은 반경, 접선, 축 방향에서 각각 1.53, 1.50, 2.33 mm이고, 체적 공간 분해능은 $5.43\;mm^3$이었다. 절대민감도는 6.61%이었다. F-18 최대 NECR은 486 kcps @121 MBq (랫 팬텀), 1056 kcps @128 MBq (마우스 팬텀)이었다. 랫과 마우스의 산란분획은 각각 20.59%, 7.93%이었다. 이 연구에서 최신 소동물용 PET인 Inveon PET의 표준성능을 평가하였고 소동물 PET영상 획득에 유용함 을 보여주었다.

Inveon PET is a recently developed preclinical PET system for small animal. This study was conducted to measure the performance of Inveon PET as recommended by the NEMA NU 4-2008. We measured the spatial resolution, the sensitivity, the scatter fraction and the NECR using a F-18 source. A 3.432 ns coincidence window was used. A $1\;mm^3$ sized F-18 point source was used for the measurement of spatial resolution within an energy window of 350~625 keV. PET acquisition was performed to obtain the spatial resolution from the center to the 5 cm offset toward the edge of the transverse FOV. Sensitivity, scatter fraction, and NECR were measured within an energy window of 350~750 keV. For measuring the sensitivity, a F-18 line source (length: 12.7 cm) was used with concentric 5 aluminum tubes. For the acquisition of the scatter fraction and the NECR, two NEMA scatter phantoms (rat: 50 mm in diameter, 150 mm in length; mouse: 25 mm in diameter, 70 mm in length) were used and the data for 14 half-lives (25.6 hr) was obtained using the F-18 line source (rat: 316 MBq, mouse: 206 MBq). The spatial resolution of the F-18 point source was 1.53, 1.50 and 2.33 mm in the radial, tangential and axial directions, respectively. The volumetric resolution was $5.43\;mm^3$ in the center. The absolute sensitivity was 6.61%. The peak NECR was 486 kcps @121 MBq (rat phantom), and 1056 kcps @128 MBq (mouse phantom). The values of the scatter fraction were 20.59% and 7.93% in the rat and mouse phantoms, respectively. The performances of the Inveon animal PET scanner were measured in this study. This scanner will be useful for animal imaging.

키워드

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