Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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Acute and Subchronic Inhalation Toxicity Evaluation of Methyl Formate in Rats

Methyl formate의 랫드를 이용한 급성 및 아만성 흡입독성 평가

  • Kim, Hyeon-Yeong (Chemical Safety & Health Research Center, Occupational Safety & Health Research Institute) ;
  • Lee, Sung-Bae (Chemical Safety & Health Research Center, Occupational Safety & Health Research Institute) ;
  • Han, Jeong-Hee (Chemical Safety & Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kang, Min-Gu (Chemical Safety & Health Research Center, Occupational Safety & Health Research Institute) ;
  • Yang, Jeong-Sun (Chemical Safety & Health Research Center, Occupational Safety & Health Research Institute)
  • 김현영 (산업안전보건연구원 화학물질안전보건센터) ;
  • 이성배 (산업안전보건연구원 화학물질안전보건센터) ;
  • 한정희 (산업안전보건연구원 화학물질안전보건센터) ;
  • 강민구 (산업안전보건연구원 화학물질안전보건센터) ;
  • 양정선 (산업안전보건연구원 화학물질안전보건센터)
  • Received : 2010.05.25
  • Accepted : 2010.06.24
  • Published : 2010.06.30
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Abstract

We performed the tests of acute and subchronic inhalation toxicity of methyl formate, which has limited toxicological data in spite of its widespread use and enhanced hazard consequent on its high volatility. The median lethal concentration ($LC_{50}$) was evaluated to be above 5,000ppm(12.27 mg/L). In the test with subchronic inhalation, there are no deaths, but with reduction of body weight, food intake, organ weight by exposure to 400 (0.98 mg/L) and 1,600 (3.92 mg/L) ppm, dose-dependently. There were statistical differences in some hematological and blood biochemical parameters as compared to control (e.g. neutrophile and lymphocyte in the 1,600 ppm group, calcium and A/G in 1,600 ppm group). Methyl formate under the exposure of 1,600 ppm showed the respiratory findings with nasal, it was confirmed that the chemical has respiratory hazard with 1,600 ppm inhalation exposure, induces nasal epithelial atrophy, olfactory cell degeneration/regeneration and the contraction of olfactory cells, etc. According to the notification with Ministry of Labor (No. 2009-68) for classification, labeling and MSDS of chemicals, it is suggested for methyl formate to be classified as category 4 in acute (10.0$4\leq20.0$ mg/L), category 2 (0.2$\leq$1.0 mg/L/6h, 90 days) in specific target organ-repeated exposure.

Keywords

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