Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Study on bisphosphonate-related osteonecrosis of the jaw (BRONJ): case report and literature review

비스포스포네이트 관련 악골괴사에 대한 연구: 증례보고 및 문헌문석

  • Kim, Yeo-Gab (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University) ;
  • Lee, Baek-Soo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University) ;
  • Kwon, Yong-Dae (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University) ;
  • Suh, Joon-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University) ;
  • Jeen, Sang-Mi (School of Dentistry, Kyung Hee University)
  • 김여갑 (경희대학교 치의학전문대학원 부속병원 구강악안면외과) ;
  • 이백수 (경희대학교 치의학전문대학원 부속병원 구강악안면외과) ;
  • 권용대 (경희대학교 치의학전문대학원 부속병원 구강악안면외과) ;
  • 서준호 (경희대학교 치의학전문대학원 부속병원 구강악안면외과) ;
  • 진상미
  • Received : 2010.05.06
  • Accepted : 2010.07.27
  • Published : 2010.08.31
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Abstract

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of Bisphosphonates (BPs) use. These days, oral bisphosphonates are normally prescribed to treat osteoporosis. Intravenous BPs are used extensively to treat osteolytic bone lesions related to multiplemyeloma and bone metastasis of solid cancers, breast cancer or prostate cancer. As the prescription of BPs is universalized and the number of people treated with BPs is increasing, an accurate understanding and proper management of BRONJ are required. The aim of this study was to improve the clinicians' understanding of BRONJ by reviewing the literature. To achieve this, this paper introduces case reports as well as the current concept of BRONJ based on the 2009 updates by American Association of Oral and Maxillofacial (AAOMS) including the definition, epidemiology, etiology, diagnosis, treatment and prevention of BRONJ.

Keywords

References

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